Jiří Pospíšil et al.

Bacterial nanotubes as a manifestation of cell death

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Physical sciences

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  • Article
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    N-myristoyltransferases (NMTs) target many signaling proteins to membranes. Here the authors show an NMT inhibitor named PCLX-001 selectively kills lymphoma cells by shutting down their main survival signaling pathway and offers an additional treatment strategy for lymphoma patients.

    • Erwan Beauchamp
    • , Megan C. Yap
    • , Aishwarya Iyer
    • , Maneka A. Perinpanayagam
    • , Jay M. Gamma
    • , Krista M. Vincent
    • , Manikandan Lakshmanan
    • , Anandhkumar Raju
    • , Vinay Tergaonkar
    • , Soo Yong Tan
    • , Soon Thye Lim
    • , Wei-Feng Dong
    • , Lynne M. Postovit
    • , Kevin D. Read
    • , David W. Gray
    • , Paul G. Wyatt
    • , John R. Mackey
    •  & Luc G. Berthiaume
  • Article
    | Open Access

    Mitochondrial ATP synthases are involved in shaping the mitochondrial cristae. The cryo-EM structure of type III ATP synthase reveals the architecture of the unusual, asymmetrical, U-shaped dimer and offers insights into the interaction with the natural inhibitor IF1 and membrane lipids. The structure of the enzyme tetramer suggests the mechanism of membrane curvature generation.

    • Rasmus Kock Flygaard
    • , Alexander Mühleip
    • , Victor Tobiasson
    •  & Alexey Amunts
  • Article
    | Open Access

    The current bottleneck for DNA data storage systems is the cost and speed of synthesis. Here, the authors use inexpensive, massively parallel light-directed synthesis and correct for a high error rate with a pipeline of encoding and reconstruction algorithms.

    • Philipp L. Antkowiak
    • , Jory Lietard
    • , Mohammad Zalbagi Darestani
    • , Mark M. Somoza
    • , Wendelin J. Stark
    • , Reinhard Heckel
    •  & Robert N. Grass

Earth and environmental sciences

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    High-latitude records show large diversity losses of marine plankton, such as radiolarians, with historical climate change. Here, Trubovitz et al. present a low-latitude record spanning the last 10 million years, finding that many high-latitude radiolarians did not shift equatorward but instead went extinct.

    • Sarah Trubovitz
    • , David Lazarus
    • , Johan Renaudie
    •  & Paula J. Noble
  • Article
    | Open Access

    Many models assume a universal carbon use efficiency across forest biomes, in contrast to assumptions of other process-based models. Here the authors analyse forest production efficiency across a wide range of climates to show a positive relationship with annual temperature and precipitation, indicating that ecosystem models are overestimating forest carbon losses under warming.

    • A. Collalti
    • , A. Ibrom
    • , A. Stockmarr
    • , A. Cescatti
    • , R. Alkama
    • , M. Fernández-Martínez
    • , G. Matteucci
    • , S. Sitch
    • , P. Friedlingstein
    • , P. Ciais
    • , D. S. Goll
    • , J. E. M. S. Nabel
    • , J. Pongratz
    • , A. Arneth
    • , V. Haverd
    •  & I. C. Prentice

Biological sciences

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  • Article
    | Open Access

    High-latitude records show large diversity losses of marine plankton, such as radiolarians, with historical climate change. Here, Trubovitz et al. present a low-latitude record spanning the last 10 million years, finding that many high-latitude radiolarians did not shift equatorward but instead went extinct.

    • Sarah Trubovitz
    • , David Lazarus
    • , Johan Renaudie
    •  & Paula J. Noble
  • Article
    | Open Access

    N-myristoyltransferases (NMTs) target many signaling proteins to membranes. Here the authors show an NMT inhibitor named PCLX-001 selectively kills lymphoma cells by shutting down their main survival signaling pathway and offers an additional treatment strategy for lymphoma patients.

    • Erwan Beauchamp
    • , Megan C. Yap
    • , Aishwarya Iyer
    • , Maneka A. Perinpanayagam
    • , Jay M. Gamma
    • , Krista M. Vincent
    • , Manikandan Lakshmanan
    • , Anandhkumar Raju
    • , Vinay Tergaonkar
    • , Soo Yong Tan
    • , Soon Thye Lim
    • , Wei-Feng Dong
    • , Lynne M. Postovit
    • , Kevin D. Read
    • , David W. Gray
    • , Paul G. Wyatt
    • , John R. Mackey
    •  & Luc G. Berthiaume

Health sciences

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  • Article
    | Open Access

    N-myristoyltransferases (NMTs) target many signaling proteins to membranes. Here the authors show an NMT inhibitor named PCLX-001 selectively kills lymphoma cells by shutting down their main survival signaling pathway and offers an additional treatment strategy for lymphoma patients.

    • Erwan Beauchamp
    • , Megan C. Yap
    • , Aishwarya Iyer
    • , Maneka A. Perinpanayagam
    • , Jay M. Gamma
    • , Krista M. Vincent
    • , Manikandan Lakshmanan
    • , Anandhkumar Raju
    • , Vinay Tergaonkar
    • , Soo Yong Tan
    • , Soon Thye Lim
    • , Wei-Feng Dong
    • , Lynne M. Postovit
    • , Kevin D. Read
    • , David W. Gray
    • , Paul G. Wyatt
    • , John R. Mackey
    •  & Luc G. Berthiaume
  • Article
    | Open Access

    Since 1970, several cholera outbreaks caused by the “seventh pandemic” (7PET) lineage have been reported in Europe. Here, the authors demonstrate that the outbreaks were caused by repeated introductions of 7PET into Europe, rather than local environmental sources.

    • Mihaela Oprea
    • , Elisabeth Njamkepo
    • , Daniela Cristea
    • , Anna Zhukova
    • , Clifford G. Clark
    • , Anatoly N. Kravetz
    • , Elena Monakhova
    • , Adriana S. Ciontea
    • , Radu Cojocaru
    • , Jean Rauzier
    • , Maria Damian
    • , Olivier Gascuel
    • , Marie-Laure Quilici
    •  & François-Xavier Weill
  • Article
    | Open Access

    Cytotoxic T lymphocyte (CTL)-based immunotherapies can induce tumor regressions by targeting HLA class I-bound tumor-associated peptides. Here, the authors identified a peptide derived from Vestigial-like 1 (VGLL1) as a shared, potentially therapeutic CTL target expressed by multiple cancer types.

    • Sherille D. Bradley
    • , Amjad H. Talukder
    • , Ivy Lai
    • , Rebecca Davis
    • , Hector Alvarez
    • , Herve Tiriac
    • , Minying Zhang
    • , Yulun Chiu
    • , Brenda Melendez
    • , Kyle R. Jackson
    • , Arjun Katailiha
    • , Heather M. Sonnemann
    • , Fenge Li
    • , Yaan Kang
    • , Na Qiao
    • , Bih-Fang Pan
    • , Philip L. Lorenzi
    • , Mark Hurd
    • , Elizabeth A. Mittendorf
    • , Christine B. Peterson
    • , Milind Javle
    • , Christopher Bristow
    • , Michael Kim
    • , David A. Tuveson
    • , David Hawke
    • , Scott Kopetz
    • , Robert A. Wolff
    • , Patrick Hwu
    • , Anirban Maitra
    • , Jason Roszik
    • , Cassian Yee
    •  & Gregory Lizée

News & Comment

  • Comment
    | Open Access

    The human body supports a thriving diversity of microbes which comprise a dynamic, ancillary, functional system that synergistically develops in lock-step with physiological development of its host. The human microbiome field has transitioned from cataloging this rich diversity to dissecting molecular mechanisms by which microbiomes influence human health. Early life microbiome development trains immune function. Thus, vertically, horizontally, and environmentally acquired microbes and their metabolites have the potential to shape developmental trajectories with life-long implications for health.

    • Elze Rackaityte
    •  & Susan V. Lynch
  • Comment
    | Open Access

    Low-temperature carbon dioxide electrolysis is an attractive process for sustainable fuel synthesis, but current systems suffer from low efficiency. In this comment, authors discuss the limitations arising from the reaction between carbon dioxide and hydroxide, highlighting the need for new research to address this fundamental problem.

    • Joshua A. Rabinowitz
    •  & Matthew W. Kanan
  • Comment
    | Open Access

    Synthetic biology is among the most hyped research topics this century, and in 2010 it entered its teenage years. But rather than these being a problematic time, we’ve seen synthetic biology blossom and deliver many new technologies and landmark achievements.

    • Fankang Meng
    •  & Tom Ellis
  • Comment
    | Open Access

    Protected areas (PAs) are the most important conservation tool, yet assessing their effectiveness is remarkably challenging. We clarify the links between the many facets of PA effectiveness, from evaluating the means, to analysing the mechanisms, to directly measuring biodiversity outcomes.

    • Ana S. L. Rodrigues
    •  & Victor Cazalis
  • Comment
    | Open Access

    Myelinating Schwann cells control the diameter of the axons they ensheath by an unknown mechanism. In a recent article in Nature Communications, Eichel and colleagues identify the tetraspan protein CMTM6 as a regulator of axonal caliber.

    • Nimrod Elazar
    •  & Elior Peles
  • Q&A
    | Open Access

    Dr. Kishana Taylor (a microbiologist and Postdoctoral Researcher at the University of California, Davis), Dr. Nella Vargas-Barbosa (an electrochemist and Scientist at the Max Planck Institute) and Dr. Anouk Beniest (a geologist and Postdoctoral Researcher at GEOMAR Helmholtz Centre for Ocean Research Kiel) talked to Nature Communications about their recent experiences at virtual conferences as early career researchers, since the onset of international COVID-19 travel restrictions. Kishana, Nella and Anouk share tips for navigating virtual conferences as junior researchers, and they also give suggestions for conference organizers to improve virtual scientific meetings so they more inclusive for younger scientists.

Focus

Therapeutics

Jaeok Park et al./doi:10.1038/ncomms14132

Therapeutics

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Ross Cloney, Francesco Conti, Sonja Schmid and Aishwarya Sundaram

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