Wenyan Nong et al.

Jellyfish genomes possess unique and conserved features

Latest Research

Physical sciences

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  • Article
    | Open Access

    Rescue of ribosomes stalled on non-stop mRNA is essential for cell viability, and several rescue systems to resolve stalling exist in bacteria. Here, the authors use rapid kinetics and cryo-EM to reveal the pathway and selectivity mechanism of ArfB-mediated ribosome rescue.

    • Kai-Hsin Chan
    • , Valentyn Petrychenko
    • , Claudia Mueller
    • , Cristina Maracci
    • , Wolf Holtkamp
    • , Daniel N. Wilson
    • , Niels Fischer
    •  & Marina V. Rodnina
  • Article
    | Open Access

    hnRNPA2 is involved in RNA metabolism and can form both functional amyloid-like fibrils in membraneless organelles, and pathogenic fibrils in neurodegenerative conditions. Here, the authors present the cryo-EM fibril structure of the wild-type hnRNPA2 low-complexity domain (LCD) and the crystal structure of a LCD segment with the disease causing D290V variant and discuss how mutations can transform fibril structure from a functional to a pathogenic form.

    • Jiahui Lu
    • , Qin Cao
    • , Michael P. Hughes
    • , Michael R. Sawaya
    • , David R. Boyer
    • , Duilio Cascio
    •  & David S. Eisenberg
  • Article
    | Open Access

    Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Here, the authors present a multinational study on the application of deep learning algorithms for COVID-19 diagnosis against multiple lung conditions as controls.

    • Stephanie A. Harmon
    • , Thomas H. Sanford
    • , Sheng Xu
    • , Evrim B. Turkbey
    • , Holger Roth
    • , Ziyue Xu
    • , Dong Yang
    • , Andriy Myronenko
    • , Victoria Anderson
    • , Amel Amalou
    • , Maxime Blain
    • , Michael Kassin
    • , Dilara Long
    • , Nicole Varble
    • , Stephanie M. Walker
    • , Ulas Bagci
    • , Anna Maria Ierardi
    • , Elvira Stellato
    • , Guido Giovanni Plensich
    • , Giuseppe Franceschelli
    • , Cristiano Girlando
    • , Giovanni Irmici
    • , Dominic Labella
    • , Dima Hammoud
    • , Ashkan Malayeri
    • , Elizabeth Jones
    • , Ronald M. Summers
    • , Peter L. Choyke
    • , Daguang Xu
    • , Mona Flores
    • , Kaku Tamura
    • , Hirofumi Obinata
    • , Hitoshi Mori
    • , Francesca Patella
    • , Maurizio Cariati
    • , Gianpaolo Carrafiello
    • , Peng An
    • , Bradford J. Wood
    •  & Baris Turkbey

Earth and environmental sciences

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  • Article
    | Open Access

    Nitriles are key intermediates in production of pharmaceuticals, agrochemicals and organic materials. Here, the authors report a nickel-catalyzed reductive cyanation of organic chlorides with CO2/NH3 and urea as cyanation reagents to afford a broad range of organic nitriles.

    • Yanan Dong
    • , Peiju Yang
    • , Shizhen Zhao
    •  & Yuehui Li
  • Article
    | Open Access

    Plant-pollinator interactions are not fixed but instead can change seasonally and across years. Here, the authors provide a holistic perspective on how plants and pollinators first enter, then comprise, and ultimately leave interaction networks over time.

    • Bernat Bramon Mora
    • , Eura Shin
    • , Paul J. CaraDonna
    •  & Daniel B. Stouffer
  • Article
    | Open Access

    The heat and electrical conductivity of Earth’s core matter represent key input quantities for geophysical models of the Earth’s core evolution and geodynamo. Here, the authors show how the scattering due to interactions between electrons has a relatively weak impact on the electrical and thermal conductivities of iron at core conditions.

    • L. V. Pourovskii
    • , J. Mravlje
    • , M. Pozzo
    •  & D. Alfè

Biological sciences

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  • Article
    | Open Access

    Rescue of ribosomes stalled on non-stop mRNA is essential for cell viability, and several rescue systems to resolve stalling exist in bacteria. Here, the authors use rapid kinetics and cryo-EM to reveal the pathway and selectivity mechanism of ArfB-mediated ribosome rescue.

    • Kai-Hsin Chan
    • , Valentyn Petrychenko
    • , Claudia Mueller
    • , Cristina Maracci
    • , Wolf Holtkamp
    • , Daniel N. Wilson
    • , Niels Fischer
    •  & Marina V. Rodnina
  • Article
    | Open Access

    hnRNPA2 is involved in RNA metabolism and can form both functional amyloid-like fibrils in membraneless organelles, and pathogenic fibrils in neurodegenerative conditions. Here, the authors present the cryo-EM fibril structure of the wild-type hnRNPA2 low-complexity domain (LCD) and the crystal structure of a LCD segment with the disease causing D290V variant and discuss how mutations can transform fibril structure from a functional to a pathogenic form.

    • Jiahui Lu
    • , Qin Cao
    • , Michael P. Hughes
    • , Michael R. Sawaya
    • , David R. Boyer
    • , Duilio Cascio
    •  & David S. Eisenberg
  • Article
    | Open Access

    Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Here, the authors present a multinational study on the application of deep learning algorithms for COVID-19 diagnosis against multiple lung conditions as controls.

    • Stephanie A. Harmon
    • , Thomas H. Sanford
    • , Sheng Xu
    • , Evrim B. Turkbey
    • , Holger Roth
    • , Ziyue Xu
    • , Dong Yang
    • , Andriy Myronenko
    • , Victoria Anderson
    • , Amel Amalou
    • , Maxime Blain
    • , Michael Kassin
    • , Dilara Long
    • , Nicole Varble
    • , Stephanie M. Walker
    • , Ulas Bagci
    • , Anna Maria Ierardi
    • , Elvira Stellato
    • , Guido Giovanni Plensich
    • , Giuseppe Franceschelli
    • , Cristiano Girlando
    • , Giovanni Irmici
    • , Dominic Labella
    • , Dima Hammoud
    • , Ashkan Malayeri
    • , Elizabeth Jones
    • , Ronald M. Summers
    • , Peter L. Choyke
    • , Daguang Xu
    • , Mona Flores
    • , Kaku Tamura
    • , Hirofumi Obinata
    • , Hitoshi Mori
    • , Francesca Patella
    • , Maurizio Cariati
    • , Gianpaolo Carrafiello
    • , Peng An
    • , Bradford J. Wood
    •  & Baris Turkbey

Health sciences

See All
  • Article
    | Open Access

    Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Here, the authors present a multinational study on the application of deep learning algorithms for COVID-19 diagnosis against multiple lung conditions as controls.

    • Stephanie A. Harmon
    • , Thomas H. Sanford
    • , Sheng Xu
    • , Evrim B. Turkbey
    • , Holger Roth
    • , Ziyue Xu
    • , Dong Yang
    • , Andriy Myronenko
    • , Victoria Anderson
    • , Amel Amalou
    • , Maxime Blain
    • , Michael Kassin
    • , Dilara Long
    • , Nicole Varble
    • , Stephanie M. Walker
    • , Ulas Bagci
    • , Anna Maria Ierardi
    • , Elvira Stellato
    • , Guido Giovanni Plensich
    • , Giuseppe Franceschelli
    • , Cristiano Girlando
    • , Giovanni Irmici
    • , Dominic Labella
    • , Dima Hammoud
    • , Ashkan Malayeri
    • , Elizabeth Jones
    • , Ronald M. Summers
    • , Peter L. Choyke
    • , Daguang Xu
    • , Mona Flores
    • , Kaku Tamura
    • , Hirofumi Obinata
    • , Hitoshi Mori
    • , Francesca Patella
    • , Maurizio Cariati
    • , Gianpaolo Carrafiello
    • , Peng An
    • , Bradford J. Wood
    •  & Baris Turkbey
  • Article
    | Open Access

    Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive pancreatic cancer, and that SMAD4/TGFBR2 alterations are likely drivers of invasion in a subset of cases.

    • Michaël Noë
    • , Noushin Niknafs
    • , Catherine G. Fischer
    • , Wenzel M. Hackeng
    • , Violeta Beleva Guthrie
    • , Waki Hosoda
    • , Marija Debeljak
    • , Eniko Papp
    • , Vilmos Adleff
    • , James R. White
    • , Claudio Luchini
    • , Antonio Pea
    • , Aldo Scarpa
    • , Giovanni Butturini
    • , Giuseppe Zamboni
    • , Paola Castelli
    • , Seung-Mo Hong
    • , Shinichi Yachida
    • , Nobuyoshi Hiraoka
    • , Anthony J. Gill
    • , Jaswinder S. Samra
    • , G. Johan A. Offerhaus
    • , Anne Hoorens
    • , Joanne Verheij
    • , Casper Jansen
    • , N. Volkan Adsay
    • , Wei Jiang
    • , Jordan Winter
    • , Jorge Albores-Saavedra
    • , Benoit Terris
    • , Elizabeth D. Thompson
    • , Nicholas J. Roberts
    • , Ralph H. Hruban
    • , Rachel Karchin
    • , Robert B. Scharpf
    • , Lodewijk A. A. Brosens
    • , Victor E. Velculescu
    •  & Laura D. Wood
  • Article
    | Open Access

    Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes features of stable plaques in a mouse model of hypercholestrolemia.

    • Huan Tao
    • , Jiansheng Huang
    • , Patricia G. Yancey
    • , Valery Yermalitsky
    • , John L. Blakemore
    • , Youmin Zhang
    • , Lei Ding
    • , Irene Zagol-Ikapitte
    • , Fei Ye
    • , Venkataraman Amarnath
    • , Olivier Boutaud
    • , John A. Oates
    • , L. Jackson Roberts II
    • , Sean S. Davies
    •  & MacRae F. Linton

News & Comment

  • Comment
    | Open Access

    Climate science and climate economics are critical sources of expertise in our pursuit of the Sustainable Development Goals. Effective use of this expertise requires a strengthening of its epistemic foundations and a renewed focus on more practical policy problems.

    • David A. Stainforth
    •  & Raphael Calel
  • Comment
    | Open Access

    Immunotherapy using immune-checkpoint modulators revolutionizes the oncology field far beyond their remarkable clinical efficacy in some patients. It creates radical changes in the evaluation of treatment efficacy and toxicity with a more holistic vision of the patient with cancer.

    • Caroline Robert
  • Comment
    | Open Access

    Organocatalysis has become a major pillar of (asymmetric) catalysis. Here, the authors discuss recent trends in organocatalytic activation modes for challenging stereoselective transformations and the emerging integration with other fields, such as photoredox catalysis and electrosynthesis.

    • Shao-Hua Xiang
    •  & Bin Tan
  • Comment
    | Open Access

    As investment in urban conservation grows, researchers must balance the needs of residents and conservation targets. We discuss some of the challenges we have encountered and the importance of taking a transdisciplinary approach informed by design and social knowledge.

    • Katherine J. Turo
    •  & Mary M. Gardiner
  • Comment
    | Open Access

    After two decades of steady growing, symbiotic merger of organocatalysis with emerging electrochemical and photochemical tools are envisioned as hot topics in the coming decade. Here, these trends are discussed in parallel to the implementation of artificial intelligence-based technologies, which anticipate a paradigm shift in catalyst design.

    • José M. Lassaletta

Focus

From Brain to Behaviour

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From Brain to Behaviour

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Fiona Carr, Jamie Horder, Sachin Ranade and Jerome Staal

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