Toshiya Ando et al.

Genetic basis for colour patterns of ladybird beetles

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  • Article | | open

    Testing the association between genetic variants and a range of phenotypes can assist drug development. Here, in a phenome-wide association study in up to 697,815 individuals, Diogo et al. identify genotype–phenotype associations predicting efficacy, alternative indications or adverse drug effects.

    • Dorothée Diogo
    • , Chao Tian
    • , Christopher S. Franklin
    • , Mervi Alanne-Kinnunen
    • , Michael March
    • , Chris C. A. Spencer
    • , Ciara Vangjeli
    • , Michael E. Weale
    • , Hannele Mattsson
    • , Elina Kilpeläinen
    • , Patrick M. A. Sleiman
    • , Dermot F. Reilly
    • , Joshua McElwee
    • , Joseph C. Maranville
    • , Arnaub K. Chatterjee
    • , Aman Bhandari
    • , Khanh-Dung H. Nguyen
    • , Karol Estrada
    • , Mary-Pat Reeve
    • , Janna Hutz
    • , Nan Bing
    • , Sally John
    • , Daniel G. MacArthur
    • , Veikko Salomaa
    • , Samuli Ripatti
    • , Hakon Hakonarson
    • , Mark J. Daly
    • , Aarno Palotie
    • , David A. Hinds
    • , Peter Donnelly
    • , Caroline S. Fox
    • , Aaron G. Day-Williams
    • , Robert M. Plenge
    •  & Heiko Runz
  • Article | | open

    Our brains predict the likely sensory consequences of actions we take; one theory is that these sensory responses are suppressed, but another theory is that they are sharpened. Here, the authors show using fMRI evidence consistent with the sharpening account for sensory consequences of hand movements.

    • Daniel Yon
    • , Sam J. Gilbert
    • , Floris P. de Lange
    •  & Clare Press
  • Article | | open

    Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.

    • Colt A. Egelston
    • , Christian Avalos
    • , Travis Y. Tu
    • , Diana L. Simons
    • , Grecia Jimenez
    • , Jae Y. Jung
    • , Laleh Melstrom
    • , Kim Margolin
    • , John H. Yim
    • , Laura Kruper
    • , Joanne Mortimer
    •  & Peter P. Lee
  • Article | | open

    Research on racial and ethnic influence on breast cancer mortality is stymied by a lack of genomic studies in diverse populations. Here, the authors genomically interrogate 194 Nigerian breast cancers, unveiling molecular features that could explain the high mortality rate from breast cancer in an indigenous African population.

    • Jason J. Pitt
    • , Markus Riester
    • , Yonglan Zheng
    • , Toshio F. Yoshimatsu
    • , Ayodele Sanni
    • , Olayiwola Oluwasola
    • , Artur Veloso
    • , Emma Labrot
    • , Shengfeng Wang
    • , Abayomi Odetunde
    • , Adeyinka Ademola
    • , Babajide Okedere
    • , Scott Mahan
    • , Rebecca Leary
    • , Maura Macomber
    • , Mustapha Ajani
    • , Ryan S. Johnson
    • , Dominic Fitzgerald
    • , A. Jason Grundstad
    • , Jigyasa H. Tuteja
    • , Galina Khramtsova
    • , Jing Zhang
    • , Elisabeth Sveen
    • , Bryce Hwang
    • , Wendy Clayton
    • , Chibuzor Nkwodimmah
    • , Bisola Famooto
    • , Esther Obasi
    • , Victor Aderoju
    • , Mobolaji Oludara
    • , Folusho Omodele
    • , Odunayo Akinyele
    • , Adewunmi Adeoye
    • , Temidayo Ogundiran
    • , Chinedum Babalola
    • , Kenzie MacIsaac
    • , Abiodun Popoola
    • , Michael P. Morrissey
    • , Lin S. Chen
    • , Jiebiao Wang
    • , Christopher O. Olopade
    • , Adeyinka G. Falusi
    • , Wendy Winckler
    • , Kerstin Haase
    • , Peter Van Loo
    • , John Obafunwa
    • , Dimitris Papoutsakis
    • , Oladosu Ojengbede
    • , Barbara Weber
    • , Nasiru Ibrahim
    • , Kevin P. White
    • , Dezheng Huo
    • , Olufunmilayo I. Olopade
    •  & Jordi Barretina
  • Article | | open

    Coupling graphene with narrow band-gap Ti2O3 nanoparticles can enable efficient mid-infrared photodetection. Here, the authors report a graphene-Ti2O3 based hybrid photodetector with high responsivity of ~300 A W-1 up to 10 μm by varying the number of graphene layers and size of Ti2O3 nanoparticles.

    • Xuechao Yu
    • , Yangyang Li
    • , Xiaonan Hu
    • , Daliang Zhang
    • , Ye Tao
    • , Zhixiong Liu
    • , Yongmin He
    • , Md. Azimul Haque
    • , Zheng Liu
    • , Tom Wu
    •  & Qi Jie Wang
  • Article | | open

    Here, the authors report on an experimental demonstration of near-field thermal radiation enhancement between metallo-dielectric multilayers separated by submicron gap distances and that near-field thermal radiation can be readily tuned by modifying the resonance condition of coupled surface plasmon polaritons.

    • Mikyung Lim
    • , Jaeman Song
    • , Seung S. Lee
    •  & Bong Jae Lee

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