Tropical cyclone exposure is associated with increased hospitalization rates in older adults

Robbie Parks et al. use Medicare data to show that tropical cyclone exposure in the United States is associated with increased hospitalization rates for older adults from many different acute causes.

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  • Naturally occurring hyperbolic polaritons exist in a class of layered materials. Here, the authors show evidence, via optical spectroscopy, of hyperbolic exciton-polaritons in phosphorene, originating from its in-plane anisotropy and strong exciton resonances.

    • Fanjie Wang
    • Chong Wang
    • Hugen Yan
    Article Open Access
  • Controlled breaking of a chemical bond by mechanical forces can provide key insight into reaction mechanisms. Here the authors, using atomic force microscopy and computations, measure the forces involved in breaking a single dative bond between a CO molecule and a ferrous phthalocyanine complex.

    • Pengcheng Chen
    • Dingxin Fan
    • Nan Yao
    Article Open Access
  • Alkene isomerizations and asymmetric C–H functionalizations have been independently studied, but their combination in one protocol is uncommon. Here the authors show a palladium-catalyzed method to iteratively “walk” a terminal alkene along a carbon chain to a position next to styrenes where a soft nucleophile is added asymmetrically.

    • Ye-Wei Chen
    • Yang Liu
    • Zhi-Tao He
    Article Open Access
  • Whereas transitions from solid- to fluid-like states in systems of active particles have received much attention, the characterization of phase transitions in active fluids with self-organized vortices so far has remained elusive. James et al. take us on a numerical tour de force from active turbulence to active vortex crystals.

    • Martin James
    • Dominik Anton Suchla
    • Michael Wilczek
    Article Open Access
  • Twisted van der Waals systems are known to host flat electronic bands, originating from moire potential. Here, the authors predict from purely geometric considerations a new type of nearly dispersionless bands in twisted bilayer MoS2, resulting from destructive interference between effective lattice hopping matrix elements.

    • Lede Xian
    • Martin Claassen
    • Angel Rubio
    Article Open Access

Subjects within Physical sciences

  • In ultraslow-spreading ridges intermittent detachment faulting could contribute to discontinuous magmatic accretion supporting the development of massive sulfide deposits. Here the authors using a multi-scale magnetic survey of the Southwest Indian Ridge constrain that an episode of detachment faulting took place 0.7-1.48 Ma, with the present fault active since 0.33 Ma.

    • Tao Wu
    • Maurice A. Tivey
    • Yunlong Liu
    Article Open Access
  • Vegetation emits organic vapors which can form aerosols in the atmosphere and influence cloud properties. Here, the authors show observational evidence that warmer temperatures lead to increased emissions of these aerosols in boreal forests which cause surface cooling, demonstrating a negative climate feedback mechanism.

    • Taina Yli-Juuti
    • Tero Mielonen
    • Annele Virtanen
    Article Open Access
  • Some regions on the Moon are permanently covered in shadow and are therefore extremely difficult to see into. We develop a deep learning driven algorithm which enhances images of these regions, allowing us to see inside them with high resolution for the first time.

    • V. T. Bickel
    • B. Moseley
    • M. Shirley
    Article Open Access
  • Integrating river system and economy-wide models in a dynamic, iterative, bidirectional fashion allows assessing some economic impacts of interventions in river systems. Here the authors use this framework to compare water resources management strategies for the Nile in a quest for efficient use of the river’s limited and stressed water resources.

    • Mohammed Basheer
    • Victor Nechifor
    • Julien J. Harou
    Article Open Access

Subjects within Earth and environmental sciences

Subjects within Biological sciences

  • Ultrasound is an important imaging modality for the detection and characterization of breast cancer, but it has been noted to have high false-positive rates. Here, the authors present an artificial intelligence system that achieves radiologist-level accuracy in identifying breast cancer in ultrasound imaging.

    • Yiqiu Shen
    • Farah E. Shamout
    • Krzysztof J. Geras
    Article Open Access
  • Despite being studied in clinical trials, CETP inhibitors are not yet an approved treatment for coronary heart disease. Here, by analyzing results from clinical trials and drug target mendelian randomization studies, the authors demonstrate that previous failure of CETP inhibitors are likely compound and not drug target-related.

    • Amand F. Schmidt
    • Nicholas B. Hunt
    • Chris Finan
    Article Open Access
  • Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis suggesting this could be the mechanism through which cardiac radiotherapy to modulates arrhythmia susceptibility.

    • David M. Zhang
    • Rachita Navara
    • Stacey L. Rentschler
    Article Open Access
  • Computer-assisted diagnosis is key for scaling up cervical cancer screening, but current algorithms perform poorly on whole slide image analysis and generalization. Here, the authors present a WSI classification and top lesion cell recommendation system using deep learning, and achieve comparable results with cytologists.

    • Shenghua Cheng
    • Sibo Liu
    • Xiuli Liu
    Article Open Access

Subjects within Health sciences

  • Integrating river system and economy-wide models in a dynamic, iterative, bidirectional fashion allows assessing some economic impacts of interventions in river systems. Here the authors use this framework to compare water resources management strategies for the Nile in a quest for efficient use of the river’s limited and stressed water resources.

    • Mohammed Basheer
    • Victor Nechifor
    • Julien J. Harou
    Article Open Access
  • Social media platforms moderating misinformation have been accused of political bias. Here, the authors use neutral social bots to show that, while there is no strong evidence for such a bias, the content to which Twitter users are exposed depends strongly on the political leaning of early Twitter connections.

    • Wen Chen
    • Diogo Pacheco
    • Filippo Menczer
    Article Open Access
  • Global demand for “blue food” is growing. In this quantitative synthesis, the authors analyse global seafood demand and project trends to 2050, finding considerable regional variation in the relationship between wealth and consumption.

    • Rosamond L. Naylor
    • Avinash Kishore
    • Beatrice Crona
    Article Open Access

Subjects within Scientific community and society

  • A bank of 59 well-characterised prostate cancer patient-derived xenografts was established, including 17 classed as research-ready covering the disease-spectrum which, plus associated resources (organoids, serum, DNA/RNA profiles, tissue), are available for collaborative projects. This eagerly-anticipated resource will facilitate pre-clinical prostate cancer therapy studies.

    • Charlotte L. Bevan
    Comment Open Access
  • Microglia are brain resident immune cells with multiple functions. However, little is known about microglia-vascular interactions. In a recent paper published in Nature Communications, Bisht et al. identify a signalling mechanism that attracts and maintains microglia at the capillary wall. Moreover, they show that microglia regulate capillary vascular tone, playing a more significant role in blood flow regulation than previously thought.

    • Kassandra Kisler
    • Angeliki Maria Nikolakopoulou
    • Berislav V. Zlokovic
    Comment Open Access
  • Spatially resolved transcriptomic data demand new computational analysis methods to derive biological insights. Here, we comment on these associated computational challenges as well as highlight the opportunities for standardized benchmarking metrics and data-sharing infrastructure in spurring innovation moving forward.

    • Lyla Atta
    • Jean Fan
    Comment Open Access
  • Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.

    • Enrico Orsi
    • Nico J. Claassens
    • Steffen N. Lindner
    Comment Open Access
  • Robust and precise characterization of the interactions between nanoengineered materials and biosystems is vital for the development of safe, efficient diagnostic and therapeutic nanomedicines. This comment discusses the key aspects of nanoparticle characteristics affecting the interpretation of nano-bio interface data.

    • Morteza Mahmoudi
    Comment Open Access
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