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Bacterial nanotubes as a manifestation of cell death

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Physical sciences

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  • Article
    | Open Access

    Magneto-optic Kerr effect microscopy is useful for dynamic magnetic studies, but is limited by the weak magneto-optical activity. Here, the authors show that extreme anti-reflection result in a Kerr amplitude as large as 20° and enables real-time detection of sub-wavelength magnetic domain reversals.

    • Dongha Kim
    • , Young-Wan Oh
    • , Jong Uk Kim
    • , Soogil Lee
    • , Arthur Baucour
    • , Jonghwa Shin
    • , Kab-Jin Kim
    • , Byong-Guk Park
    •  & Min-Kyo Seo
  • Article
    | Open Access

    Chiral α-amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral α-aryl glycines in high yields and enantioselectivities.

    • Dan Liu
    • , Bowen Li
    • , Jianzhong Chen
    • , Ilya D. Gridnev
    • , Deyue Yan
    •  & Wanbin Zhang
  • Article
    | Open Access

    The synthesis of closo-carboranes with more than 14 vertexes is challenging, and no examples have been reported to date. Herein, the authors present the long-sought 15- and 16-vertex closo-carboranes, in which the introduction of silyl groups to the two cage carbons is crucial; this finding might enable the synthesis of even larger carborane analogs in the future.

    • Fangrui Zheng
    • , Tsz Hin Yui
    • , Jiji Zhang
    •  & Zuowei Xie

Earth and environmental sciences

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    The Greenland Ice Sheet is the largest land ice contributor to sea level rise and understanding the long-term glacier response to external forcing is key to improved projections. Here the authors show Greenland’s three largest outlet glaciers will likely exceed current worst-case scenario

    • Shfaqat A. Khan
    • , Anders A. Bjørk
    • , Jonathan L. Bamber
    • , Mathieu Morlighem
    • , Michael Bevis
    • , Kurt H. Kjær
    • , Jérémie Mouginot
    • , Anja Løkkegaard
    • , David M. Holland
    • , Andy Aschwanden
    • , Bao Zhang
    • , Veit Helm
    • , Niels J. Korsgaard
    • , William Colgan
    • , Nicolaj K. Larsen
    • , Lin Liu
    • , Karina Hansen
    • , Valentina Barletta
    • , Trine S. Dahl-Jensen
    • , Anne Sofie Søndergaard
    • , Beata M. Csatho
    • , Ingo Sasgen
    • , Jason Box
    •  & Toni Schenk
  • Article
    | Open Access

    Local human activities can lead to cross-border environmental impacts through the food–energy–water–CO2 nexus. Here, the authors report wide variations in environmental impacts of irrigated agriculture across counties within the North China Plain under different environmental and socioeconomic scenarios.

    • Zhenci Xu
    • , Xiuzhi Chen
    • , Jianguo Liu
    • , Yu Zhang
    • , Sophia Chau
    • , Nishan Bhattarai
    • , Ye Wang
    • , Yingjie Li
    • , Thomas Connor
    •  & Yunkai Li
  • Article
    | Open Access

    As the climate warms, soil carbon stores will likely be degraded by microbes and released as CO2, but these predictions are based on laboratory incubations that might not reflect real rates. Here the authors optimize model projections using dozens of short- and long-term incubations in forest and grasslands.

    • Siyang Jian
    • , Jianwei Li
    • , Gangsheng Wang
    • , Laurel A. Kluber
    • , Christopher W. Schadt
    • , Junyi Liang
    •  & Melanie A. Mayes

Biological sciences

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  • Review Article
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    Histone H2A monoubiquitination on lysine 119 in vertebrate and lysine 118 in Drosophila (H2Aub) is an epigenomic mark usually associated with gene repression by Polycomb group factors. Here the authors review the current knowledge on the deposition and removal of H2Aub, its function in transcription and other DNA-associated processes as well as its relevance to human disease.

    • Haithem Barbour
    • , Salima Daou
    • , Michael Hendzel
    •  & El Bachir Affar
  • Article
    | Open Access

    The challenge of sensory substitution as a therapeutic approach is to design systems that are well accepted by subjects. Here, in deaf songbirds, the authors substitute hearing with vision, suggesting substitution devices could provide sensory feedback for the key actions that are deprived.

    • Anja T. Zai
    • , Sophie Cavé-Lopez
    • , Manon Rolland
    • , Nicolas Giret
    •  & Richard H. R. Hahnloser
  • Article
    | Open Access

    Type I-C Cascade (the CRISPR-associated complex for antiviral defense) is a minimal system, comprising only three unique Cas proteins. Cryo-EM structure of the Desulfovibrio vulgaris type I-C Cascade reveals the molecular mechanisms that underlie RNA-directed complex assembly.

    • Roisin E. O’Brien
    • , Inês C. Santos
    • , Daniel Wrapp
    • , Jack P. K. Bravo
    • , Evan A. Schwartz
    • , Jennifer S. Brodbelt
    •  & David W. Taylor

Health sciences

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    ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon phosphoethanolamine supplementation.

    • Diletta Fontana
    • , Mario Mauri
    • , Rossella Renso
    • , Mattia Docci
    • , Ilaria Crespiatico
    • , Lisa M. Røst
    • , Mi Jang
    • , Antonio Niro
    • , Deborah D’Aliberti
    • , Luca Massimino
    • , Mayla Bertagna
    • , Giovanni Zambrotta
    • , Mario Bossi
    • , Stefania Citterio
    • , Barbara Crescenzi
    • , Francesca Fanelli
    • , Valeria Cassina
    • , Roberta Corti
    • , Domenico Salerno
    • , Luca Nardo
    • , Clizia Chinello
    • , Francesco Mantegazza
    • , Cristina Mecucci
    • , Fulvio Magni
    • , Guido Cavaletti
    • , Per Bruheim
    • , Delphine Rea
    • , Steen Larsen
    • , Carlo Gambacorti-Passerini
    •  & Rocco Piazza
  • Article
    | Open Access

    Here, Griffiths et al. show infection of 80–100% of sampled vampire bats in Peru with a newly discovered betaherpesvirus (DrBHV) that exhibits specificity within neotropical bats and evidence for superinfection. These data suggest that DrBHV could be a candidate for virally vectored vaccines that spread autonomously through a bat population.

    • Megan E. Griffiths
    • , Laura M. Bergner
    • , Alice Broos
    • , Diana K. Meza
    • , Ana da Silva Filipe
    • , Andrew Davison
    • , Carlos Tello
    • , Daniel J. Becker
    •  & Daniel G. Streicker
  • Article
    | Open Access

    CAR T therapy has some efficacy in the treatment of patients with refractory/relapsed B-cell acute lymphoblastic leukemia; however in some patients further relapse is encountered. Here, the authors conduct a Phase II clinical trial of a CD19 CAR T and demonstrate that patients with extramedullary disease are more likely to relapse than those without.

    • Furun An
    • , Huiping Wang
    • , Zhenyun Liu
    • , Fan Wu
    • , Jiakui Zhang
    • , Qianshan Tao
    • , Yingwei Li
    • , Yuanyuan Shen
    • , Yanjie Ruan
    • , Qing Zhang
    • , Ying Pan
    • , Weiwei Zhu
    • , Hui Qin
    • , Yansheng Wang
    • , Yongling Fu
    • , Zhenqing Feng
    •  & Zhimin Zhai

News & Comment

  • Comment
    | Open Access

    Electrochemical carbon dioxide (CO2) reduction has the potential to sustainably produce carbon-based fuels and chemicals while mitigating the increasing levels of CO2 in the atmosphere. In this comment, the author discusses a few basic concepts in the fundamental mechanistic studies of electrochemical CO2 reduction.

    • Karen Chan
  • Comment
    | Open Access

    Over the past 15 years, genome-wide association studies (GWASs) have generated a wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution genome-screens will continue to drive gene discovery in years ahead. Meanwhile, GWAS loci are increasingly translated into new biology and opportunities for clinical care.

    • Ruth J. F. Loos
  • Q&A
    | Open Access

    Dr. Yi Liu is the facility director at the Molecular Foundry, Lawrence Berkeley National Laboratory. Trained as a supramolecular chemist and after a postdoctoral stay and working on click chemistry in Sharpless’s group he started his independent research career working on organic electronics, porous materials, and covalent organic frameworks (COFs). His aim is to develop nanostructured electronic materials through the design, synthesis and manipulation of tailor-made molecular constituents.

  • Q&A
    | Open Access

    Prof. Donglin Jiang is a full professor at the National University of Singapore and is recognized as a pioneer in the field of 2D polymers and covalent organic frameworks (COFs). With a background in chemistry and studies on dendrimers for ten years, the beauty of dendrimers inspired him to consider the possibility of constructing other types of polymers with well-defined shapes and structures. After taking up an associate professorship in 2005 to set up an independent laboratory at the Institute for Molecular Science at the National Institute for Natural Science, he started to dedicate his work on the design, synthesis and functional exploration of 2D polymers, COFs and conjugated microporous polymers.

  • Q&A
    | Open Access

    Professor Xiaodong Zou is a full professor and chair of Inorganic and Structural Chemistry and deputy head of the Department of Materials and Environmental Chemistry at Stockholm University. After completing her PhD in structural chemistry and electron crystallography, she started at the beginning of her independent career to apply these techniques in solving structures of porous materials. She first worked on development of inorganic porous materials, such as zeolites and related open-frameworks. A joint project with Prof. Michael O’Keeffe drew her attention to metal organic frameworks (MOFs), covalent organic frameworks (COFs) and reticular synthesis. Since then, she is working on developing structure characterization techniques for porous materials.

  • Comment
    | Open Access

    Scientists increasingly post images and photos on social media to share their research activities. However, posting images and photos could potentially exclude people with visual impairments. Here, we outline actions that should be taken to foster accessibility and inclusion in posting scientific images on social media.

    • Domenico Chiarella
    • , Justin Yarbrough
    •  & Christopher A.-L. Jackson

Focus

Energy Materials

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Energy Materials

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Prateek Dongare, Benjamin Martindale, Adam Weingarten and Yaoqing Zhang

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