Cooperative transitions have acquired much attention for low transition barriers, ultrafast kinetics, and structural reversibility but cooperative transitions are rare in molecular crystals and their origin is poorly understood. Here the authors show that reorientation of the alkyl side chains in a 2-dimensional quinoidal terthiophene triggers cooperative behavior, and establish alkyl chain engineering to control the polymorphic behavior.

Furfural is an important platform chemical for the synthesis of next-generation bio-fuels. Here the authors report a novel heterogeneous catalyst, Pd-PdO/ZnSO₄, for the mass production of furfural from catalytic flash pyrolysis of lignocellulosic biomasses.

Structuring organic films is of scientific and technological interest. Here, the authors use partially fluorinated organic molecules exhibiting strong intermolecular interactions to form extended 2D molecular nanosheets and control their shape through growth and desorption kinetics.

Uracil was identified in the sample returned from the asteroid Ryugu. Having been provided to the early Earth as a component in such asteroidal materials, these molecules might have played a role for prebiotic chemical evolution on the early Earth

Visualization of large complex networks is challenging with limitations for the network size and depicting specific structures. The authors propose a Graph Neural Network based algorithm with improved speed and the quality of graph layouts, which allows for fast and informative visualization of large networks.

One of the main sources of uncertainty in carbon budgets is that continental landscapes are made up of a heterogeneous mosaic of ecosystems. Here the authors put forward an integrative framework to improve estimates of land-atmosphere carbon exchange based on the accumulation of carbon in the landscape as constrained by its lateral export through rivers.

Uracil was identified in the sample returned from the asteroid Ryugu. Having been provided to the early Earth as a component in such asteroidal materials, these molecules might have played a role for prebiotic chemical evolution on the early Earth

Establishing sustainable approaches for human space exploration is key to achieve independency from terrestrial resources, as well as for ethical considerations. Here the authors highlight microbial biotechnologies that will support sustainable processes for space-based in situ resource utilization and loop-closure, and may be translatable to Earth applications.

Faults responsible for the 2019 M7.1 Ridgecrest, California earthquake likely evolved through reactivation of pre-existing Independence dike swarm structures. The inherited rupture geometry strongly controlled the earthquake slip distribution.

Compiled data on litterfall and litter in eucalypt forests and woodlands for the Australian continent shows that litter mass can be robustly predicted using just three independent variables – time, aridity and litterfall quality

There is a lack of standardisation in slide microscopy imaging data. Here the authors report Slim, an open-source, web-based slide microscopy viewer implementing the Digital Imaging and Communications in Medicine (DICOM) standard to achieve interoperability with a range of existing medical imaging systems.

This study comprehensively benchmarks 18 state-of-the-art methods for cellular deconvolution of spatial transcriptomics and provide decision-tree-style guidelines and recommendations for method selection.

Fluorescence imaging of the spinal cord poses challenges, including depth of imaging. Here the authors describe a custom microscope and chronically implanted microprism that enables multicolor translaminar imaging of sensory and motor evoked activity in behaving mice, and show that spinal astrocytes show sensorimotor program-dependent calcium excitation.

Immune checkpoint inhibitors (ICI) may have unanticipated side effects in transplant recipients who subsequently develop tumors. Here the authors used single-cell sequencing to identify and characterize allogeneic reactive T cells that developed after an ICI course for melanoma in a transplant recipient.

Pan-genomes provide useful resources for evolutionary studies, functional genomics and breeding of cultivated plants. Here, the authors report a new rice pan-genome including 73 Asian rice and two wild relatives (Oryza rufipogon and O. punctata), and reveal the prevalence and scale of large inversions across the pan-genome.

There is a lack of standardisation in slide microscopy imaging data. Here the authors report Slim, an open-source, web-based slide microscopy viewer implementing the Digital Imaging and Communications in Medicine (DICOM) standard to achieve interoperability with a range of existing medical imaging systems.

A genome-wide association study of cardiac magnetic resonance-derived left ventricular mass index including 43,000 UK Biobank participants reveals 12 associations (11 novel), implicating genes involved in cardiac contractility and cardiomyopathy.

Isolated fetal ventriculomegaly is the most common antenatally-diagnosed brain abnormality. Here, the authors show that isolated fetal ventriculomegaly is associated with autism spectrum disorder traits.

Cardiac neural crest must differentiate and migrate correctly to achieve proper cardiovascular development. Here, the authors use single cell analyses to show how these cells are altered non-autonomously by loss of Tbx1, the major gene for 22q11.2 deletion syndrome.

Immune checkpoint inhibitors (ICI) may have unanticipated side effects in transplant recipients who subsequently develop tumors. Here the authors used single-cell sequencing to identify and characterize allogeneic reactive T cells that developed after an ICI course for melanoma in a transplant recipient.

A more equitable global distribution of vaccines can benefit the world, while a multilateral benefit-sharing instrument needs to be developed to remove some of the disincentives for early equitable vaccines distribution globally.

Establishing sustainable approaches for human space exploration is key to achieve independency from terrestrial resources, as well as for ethical considerations. Here the authors highlight microbial biotechnologies that will support sustainable processes for space-based in situ resource utilization and loop-closure, and may be translatable to Earth applications.

Who pays for climate change mitigation is an ongoing source of conflict. Here the authors examine how historical carbon emissions influences how much people will pay for climate change mitigation via an economic experiment.

There are conflicting results on the effectiveness of pharmacologic interventions for suicide prevention in adolescence. Here, the authors show, in a retrospective registry study from Sweden during 2016–2020, that regional utilization rates of clozapine, electroconvulsive therapy and lithium in 15–19-year-olds were associated with lower excess suicide death rates in male adolescents

Under a high-cost scenario for battery critical materials, the uptake of electric vehicles in China may be greatly reduced, leading to increased cumulative carbon emissions. This may jeopardize both China’s electric vehicle and climate targets.