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    Welcome to 'The Epitranscriptome', an article collection from various Nature journals highlighting the role of mRNA modifications in RNA fate and gene expression.

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    This special issue, the last of our 10th anniversary Vol., presents a collection of articles focused on "Frontiers in chemical biology" and identifies some of the emerging scientific areas that will engage chemical biologists in the coming years.

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    This special issue features Commentaries, Reviews and Perspectives highlighting advances in our understanding of natural product biosynthesis at the chemical, structural, informatic and ecological level, along with new opportunities to create natural product analogues for a variety of applications.

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    With the June 2015 issue, Nature Chemical Biologycelebrates 10 years of serving the chemical biology community. In honor of this anniversary, we are presenting a collection of articles that highlights the scientific accomplishments and promising future of chemical biology.

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    Proteostasis is a cellular network that ensures proteome integrity. In this focus issue, we present a collection of articles that discuss how recent advances in chemical biology are improving our mechanistic understanding of proteostasis and are guiding the development of chemical tools and small molecules to probe protein homeostasis.

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    Light defines life on Earth through processes such as photosynthesis and vision, but also plays an increasingly important role in scientific research as a readout or regulator of biomolecular function. In this issue, we present a collection of articles that explore light in biology.

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    Peptides play a role in all aspects of the immunological responses to invading pathogens and tumor cells. The Review, Perspective and Commentary pieces in this issue explore the generation and molecular mechanisms of peptides and the considerations and strategies needed to harness them to treat disease.

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    In this issue, we present a collection of articles that tackle the challenges in the discovery and validation of new targets for clinical purposes, the application of chemical probes to understand the relationship between targets and biology and the expanding assortment of chemical tools and techniques that can be used to perturb targets that have been considered chemically intractable.

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    Metabolism is moving beyond flat biochemical charts into three dimensions, where dynamics in time and space lead to distinct biological outcomes and manipulation of metabolic pathways have the potential to address medical and societal needs. In this focus issue, we feature a collection of commentary and review articles that outline some of the ideas, advances and goals that are laying the foundations for the next era of metabolism research.

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    Small molecules play important roles as metabolites in the physiology, ecology and evolution of microorganisms. This issue includes a collection of articles aimed at understanding the chemical interactions of microbes with their environment, with an aim towards new anti-microbials and new biological insights.

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    Chemical biologists continue to discover how cells translate chemical or physical inputs into biological outputs. This issue includes a collection of articles that delineates the complexity of these switches, highlighting current ideas and future challenges in this research arena.

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    Big science' initiatives and investigator-driven 'small science' research in chemical biology will both contribute to a more integrated view of biological systems.