Peptides in Immunology

Mobilizing peptides in immunity - p747

doi:10.1038/nchembio.1409

Harnessing the immune system to treat disease will be facilitated by a greater understanding of the origins and roles of peptides in immunity.

Full Text - Mobilizing peptides in immunity | PDF (71 KB) - Mobilizing peptides in immunity

Peptides in Immunology

Designing immunogenic peptides - pp749 - 753

Darren R Flower

doi:10.1038/nchembio.1383

Peptides fulfill many roles in immunology, yet none are more important than their role as immunogenic epitopes driving the adaptive immune response, our ultimate bulwark against infectious disease. Peptide epitopes are mediated primarily by their interaction with major histocompatibility complexes (T-cell epitopes) and antibodies (B-cell epitopes). As pathogen genomes continue to be revealed, both experimental and computational epitope mapping are becoming crucial tools in vaccine discovery^1,2. Immunoinformatics offers many tools, techniques and approaches for in silico epitope characterization, which is capable of greatly accelerating epitope design.

Full Text - Designing immunogenic peptides | PDF (640 KB) - Designing immunogenic peptides

Peptides in Immunology

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides - pp761 - 768

Ashley L Hilchie, Kelli Wuerth & Robert E W Hancock

doi:10.1038/nchembio.1393

Abstract - Immune modulation by multifaceted cationic host defense (antimicrobial) peptides | Full Text - Immune modulation by multifaceted cationic host defense (antimicrobial) peptides | PDF (786 KB) - Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

Peptides in Immunology

A peptide's perspective on antigen presentation to the immune system - pp769 - 775

Jacques Neefjes & Huib Ovaa

doi:10.1038/nchembio.1391

Abstract - A peptide's perspective on antigen presentation to the immune system | Full Text - A peptide's perspective on antigen presentation to the immune system | PDF (1.57 MB) - A peptide's perspective on antigen presentation to the immune system

Peptides in Immunology

Adaptive immune activation: glycosylation does matter - pp776 - 784

Margreet A Wolfert & Geert-Jan Boons

doi:10.1038/nchembio.1403

Abstract - Adaptive immune activation: glycosylation does matter | Full Text - Adaptive immune activation: glycosylation does matter | PDF (1.47 MB) - Adaptive immune activation: glycosylation does matter