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    Phase separation (PS) refers to the de-mixing process of a homogenous phase to form dense and dilute phases, which is explored in this collection of recent articles from Nature Chemical Biology that aim to reveal the molecular and chemical principles underlying phase-separated condensate formation, promote the development of new tools for the study of PS biology, and broaden the application of these tools in chemical biology and biomedicine.

    Image: Xuefeng Sun (photography), Hao He (image editing), Guangya Zhu (design)

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    This themed issue presents a collection of Reviews, Perspectives and Articles that aims to showcase how chemical tools have strengthened the existing interplay between physiology, chemical biology and biochemistry – to reveal new insights into cellular regulation.

    Image: filo / DigitalVision Vectors / Getty Images

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    This themed issue combines Reviews and Perspectives as well as original research that highlight the evolution of the approaches and conceptual advances in the study of cellular membranes and their component parts, lipids and proteins.

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    The June 2020 issue of Nature Chemical Biology marks 15 years of publication for the chemical biology community.

    Image: John Tolliday / Alamy Stock Photo; Cover Design: Erin Dewalt

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    In our March 2018 issue, Nature Chemical Biology presents a collection that explores chemical tailoring of biomolecules within cells and highlights how chemical biology expands our mechanistic understanding of these modified biomolecules and provides tools to illuminate their biological functions.

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    The development of model organisms such as zebrafish and worms progresses from a single cell to tissues and organs. In this issue, a collection of articles highlights advances and opportunities at the intersection of developmental and chemical biology.

    Image: Credit: Erin Dewalt / Springer Nature

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    This special issue, the last of our 10th anniversary Vol., presents a collection of articles focused on "Frontiers in chemical biology" and identifies some of the emerging scientific areas that will engage chemical biologists in the coming years.

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    This special issue features Commentaries, Reviews and Perspectives highlighting advances in our understanding of natural product biosynthesis at the chemical, structural, informatic and ecological level, along with new opportunities to create natural product analogues for a variety of applications.

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    With the June 2015 issue, Nature Chemical Biologycelebrates 10 years of serving the chemical biology community. In honor of this anniversary, we are presenting a collection of articles that highlights the scientific accomplishments and promising future of chemical biology.

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    Proteostasis is a cellular network that ensures proteome integrity. In this focus issue, we present a collection of articles that discuss how recent advances in chemical biology are improving our mechanistic understanding of proteostasis and are guiding the development of chemical tools and small molecules to probe protein homeostasis.

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    Light defines life on Earth through processes such as photosynthesis and vision, but also plays an increasingly important role in scientific research as a readout or regulator of biomolecular function. In this issue, we present a collection of articles that explore light in biology.

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    Peptides play a role in all aspects of the immunological responses to invading pathogens and tumor cells. The Review, Perspective and Commentary pieces in this issue explore the generation and molecular mechanisms of peptides and the considerations and strategies needed to harness them to treat disease.