Artistic representation of an enzyme adopting a misfolded structure during the folding process.

Read our March issue

This month we have a Meeting Report from the LGBTQ+ STEM Day held last year, a Q+A with Matthew Horwitz of the Synthesis Workshop podcast, and an In Your Element article focussing on cucurbiturils.


  • A Nobel medal in the foreground with some beakers and flasks in the background.

    The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for the development of click chemistry and bioorthogonal chemistry. In recognition of this award, Nature Portfolio presents a collection of research, review and opinion articles that focus on the origins, the development and the future directions inspired by the topic.

  • Nature Synthesis is open for submissions of original research articles. The journal will publish research, reviews and opinion articles on chemical and materials synthesis as well as enabling technological innovations.

  • COVID-19 and impact on peer review

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  • Water-soluble, cell-permeable, inert fluorescent tags called OregonFluors have been developed to withstand environmental changes while resistant towards non-specific binding with subcellular structures. These tags enable quantitative imaging of drug target availability in cells and tissues, providing a route for the future assessment of personalized therapies.

    • Lei G. Wang
    • Antonio R. Montaño
    • Summer L. Gibbs
  • Borylated bicyclopentanes and bicyclohexanes are valuable compounds in drug research but are difficult to prepare. Now, an iridium-catalysed method has been developed for the borylation of the bridgehead tertiary C–H bonds in bicyclopentanes and bicyclohexanes, providing access to a variety of highly decorated bicyclic cores.

    • Isaac F. Yu
    • Jenna L. Manske
    • John F. Hartwig
  • Californium is difficult to prepare in its divalent state. Now, crystals of a Cf(II) crown–ether complex have been synthesized by reduction of a Cf(III) precursor with an Al/Hg amalgam. They exhibit 5f→6d transitions in the visible region and near-infrared emission that are highly sensitive to changes in the coordination environment.

    • Todd N. Poe
    • Harry Ramanantoanina
    • Cristian Celis-Barros
  • In contrast to phosphine and arsine oxides, stibine oxides have been challenging to isolate in monomeric forms as they tend to polymerize. Now, such a SbO moiety has been kinetically stabilized using sterically bulky protecting groups, and its reactivity found to be substantially different to that of its lighter pnictogen counterparts.

    • John S. Wenger
    • Monica Weng
    • Timothy C. Johnstone
    Article Open Access
  • Quasicrystals are intriguing structures that exhibit long-range positional correlations but no periodicity in real space. Now, T-shaped amphiphilic molecules featuring rigid cores have been found to self-assemble into a columnar liquid quasicrystal with dodecagonal symmetry. The honeycomb structure observed arises from a strictly quasiperiodic tessellation of square, triangular and trapezoidal tiles, rather than from random tiling.

    • Xiangbing Zeng
    • Benjamin Glettner
    • Carsten Tschierske
    • Therapies that destroy senescent cells could be used to alleviate age-related disease, yet conventional drugs often suffer from low selectivity and unwanted side effects. Now, a photosensitive agent has been developed that is activated in situ in senescent cells, enabling their selective elimination.

      • Yunjie Xu
      • Jong Seung Kim
      • Mingle Li
      News & Views
    • Charge-transfer emission of any type is extremely rare for coordination complexes of iron. Now, an Fe(iii) complex has been devised that shows two-colour luminescence arising from dual metal-to-ligand and ligand-to-metal charge-transfer emission.

      • Robert J. Ortiz
      • David E. Herbert
      News & Views
    • Serial rotation electron diffraction (SerialRED) enables rapid and reliable phase analysis and structure determination of complex polycrystalline materials that cannot be routinely characterized using X-ray diffraction. Five zeolite phases were identified in a single synthesis product by automated screening of hundreds of crystals, demonstrating the power of SerialRED for materials development.

      Research Briefing
    • Nanomachines are central to life and are becoming an important part of self-regulated nanotechnologies. Inspired by natural self-assembled nanosystems, it has been shown that artificial nanosystems can evolve and adopt regulatory functions upon fragmentation of their structures into multiple components that reassemble to form the same nanostructure.

      Research Briefing
  • Jane Liao and Allie C. Obermeyer explore the discovery, modification and applications of green fluorescent protein, best known for its use as a tool to cast light on cellular processes.

    • Jane Liao
    • Allie C. Obermeyer
    In Your Element
  • Does the pursuit of scientific research based on a well-defined technological outcome hamper our ability to be creative? And does it limit opportunities to explore and develop fundamental areas of science that may ultimately lead to applications we hadn’t even thought of yet?

    • Ksenija D. Glusac
    • Radomir N. Saicic
  • Zafra Lerman talks to Nature Chemistry about embedding art in science education, and science in the pursuit of peace on Earth.

    • Anne Pichon
  • The time between accepting a position as an assistant professor and taking the role is exciting and unique. But how much work is required before you even start? Shira Joudan ponders which tasks are necessary and how many times one should interrupt a very well-deserved break.

    • Shira Joudan
  • Rahul Dev Mukhopadhyay and Kimoon Kim consider how cucurbiturils — pumpkin-shaped macrocycles — went from curiosities to compelling cavitands for a host of applications.

    • Rahul Dev Mukhopadhyay
    • Kimoon Kim
    In Your Element
  • Matthew Horwitz, creator of the Synthesis Workshop video podcast, talks to Nature Chemistry about using podcasting as a driver of professional-level education in the chemistry community.

    • Katherine Geogheghan

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