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Volume 7 Issue 12, December 2005

Volume 7 Issue 12

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Editorial

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Book Review

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Meeting Report

  • A fusion of cutting-edge research in cell biology, developmental biology and immunology made the recent workshop on Membrane Dynamics in Endocytosis an outstanding success. Members of an increasingly diverse community converged upon the small town of Sant Feliu de Guixols on the coast of Spain, between September 17–22, 2005, to discuss common themes emerging from their studies on membrane transport. Organized by Margaret Robinson (Cambridge, UK) and Howard Riezman (Geneva, Switzerland), the meeting covered diverse topics that highlighted essential roles for endocytosis during cell growth, development and parasitic invasion.

    • Barth D. Grant
    • Anjon Audhya
    Meeting Report
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News & Views

  • In myotonic dystrophy, a group of RNA-binding factors — the Muscleblind-like proteins — are sequestered by transcripts containing expanded trinucleotide repeats; this sequestration disrupts their proposed physiological function as regulators of alternative splicing. Now, exciting data suggest that Muscleblind-like proteins are also involved in the localization of integrin mRNA.

    • Goncalo Rebelo de Andrade
    • Ralf-Peter Jansen
    News & Views

  • Neurotransmitter receptors must be targeted to the post-synaptic membrane to perform their function in synaptic transmission. Recent findings reveal a surprising role for heterotrimeric G proteins and their activator, Pins (Partner of Inscuteable), in this important protein targeting event.

    • Juergen A. Knoblich
    News & Views

  • β-arrestin, a protein known to regulate the signalling, trafficking and degradation of mammalian seven-transmembrane-spanning receptors, has now been identified as a regulator of ubiquitination and degradation of the Notch receptor in Drosophila melanogaster.

    • Sudha K. Shenoy
    • Robert J. Lefkowitz
    News & Views

  • Phagocytes may engulf both apoptotic and viable cells via calreticulin on the surface of the target cell, through its interaction with the phagocyte receptor, LRP. In reality, however, only apoptotic cells are engulfed, apparently because their surface ligand CD47 is prevented from activating the inhibitory phagocyte receptor SIRPα.

    • Christopher D. Gregory
    • Simon B. Brown
    News & Views

  • Polycystin-1 and -2 — two integral membrane proteins that are mutated in polycystic kidney disease — regulate the cell cycle by preventing nuclear localization of the pro-proliferative helix-loop-helix (HLH) protein Id2. This novel mechanism for restraining Id proteins has important implications for our understanding of the nature of polycystic kidney disease and perhaps other proliferative disorders.

    • Robert Benezra
    News & Views
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