Volume 7

  • No. 11 November 2005

    Tankyrase-1, and the poly(ADPribose) it polymerizes, are required for mitotic spindle function. Knock-down of the protein in HeLa cells leads to spindle pole splitting, and loss of spindle bipolarity as shown in this electron micrograph.

  • No. 10 October 2005

    Microtubules of cortical arrays in plant cells are nucleated on existing microtubules as branches. Overlaid colour images are shown of the cortical microtubules in living tobacco cells at 5-minute intervals.

  • No. 9 September 2005

    Release of phospho-caveolin-1 (red) from focal adhesions (vinculin in green) stimulates integrin-mediated internalization of membrane microdomains.

  • No. 8 August 2005

    Prohibitin is important for cell migration and its depletion induces changes in epithelial morphogenesis.

    Focus

    Focus on the ubiquitin-proteasome system

  • No. 7 July 2005

    Severe telomere fusion phenotype upon loss of TRF2. The metaphase spread shown is derived from TRF2-/- p53-/- MEFs generated by Cre-mediated deletion of a floxed TRF2 allele.

  • No. 6 June 2005

    A three-dimensional reconstruction, showing GFP-dDia2 (green) localized to the distal tips of filopodial actin filaments (red) in Dictyostelium.

  • No. 5 May 2005

    The ATM inhibitor KU-55933 bound to the ATM kinase domain is shown next to an HIV-1-infected T cell. Cover designed with the help of Lotte Mai Lessware and Xiao-Ling Cockcroft (T-cell image copyright J.L. Carson/Custom Medical Stock Photo).

  • No. 4 April 2005

    The Arabidopsis formin mutant athfh5-2 shows defects in cellularization. The image is false coloured, highlighting cellularization in yellow and dividing nuclei in blue.

  • No. 3 March 2005

    Phosphorylation of Pan1, an activator of actin polymerization, turns off actin assembly during endocytosis (actin, green; endocytic vesicle, red).

  • No. 2 February 2005

    Myo-XVa is important for normal elongation of vestibular hair-cell stereocilia, stained here with rhodamine-phalloidin and intentionally splayed to visualize individual stereocilia.

  • No. 1 January 2005

    Architecture of gap-junction net-works in the cochlea of a guinea-pig organ of Corti. Connexin 26 expression is shown superimposed onto the staircase designed by architect and designer Antoni Gaudi Cornet (www.sagradafamilia.org/eng/index.htm ). The coiled shape of the staircase recalls that of the mammalian auditory organ (www.vimm.it/cochlea). cover design: Lawrence Keogh