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Volume 5 Issue 1, January 2003

The Drosophila melanogaster HOAP protein is specifically localized at all mitotic telomeres and is required for telomere capping. The metaphase spread shown is from a female cell. Both chromosomes and HOAP telomeric signals have been pseudo-coloured. Cover design: James McQuat

Editorial

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Commentary

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News & Views

  • Bcl-2 and Bcl-xL perform important functions in cell life or death decisions by setting the threshold for activation of the programmed cell death machinery. FKBP38, a member of the immunophilin family, has now been identified as a new Bcl-2/Bcl-xL-binding partner. Furthermore, FKBP38 seems to be crucial in targeting Bcl-2/Bcl-xL to the correct cellular locations.

    • Colin Adrain
    • Emma M. Creagh
    • Seamus J. Martin
    News & Views
  • The establishment and maintenance of apicobasal cell polarity is of fundamental importance for most physiological functions of epithelial tissues. In Drosophila melanogaster, several critical regulators of cell polarity have been identified over the past years, but we are just beginning to understand how these genes interact with each other. Two new papers now shed light on the genetic hierarchy that rules this process.

    • Kevin Johnson
    • Andreas Wodarz
    News & Views
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Meeting Report

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Book Review

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Article

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Letter

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Brief Communication

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Erratum

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