Microglia mediate a pro-inflammatory response to restrict brain metastasis in breast cancer.

See Evans et al.

During heat shock, Hsp70 and co-chaperones prevent aggregation of orphan ribosomal proteins, keeping them as nucleolar-associated, liquid-like condensates that are readily reversible.

See Ali et al. and News & Views by Green

Dedifferentiation of Gata6+ epidermal cells occurs during wound healing and stretching of unwounded skin through a Myc-dependent process that resembles reversal of differentiation.

See Bernabé-Rubio et al.

ELL3 binds a subset of young LINE-1 elements, which activate Akt3 and ERK signalling to regulate naive pluripotency.

See Meng et al.

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase — the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

See Jain et al.

Combining rabbit and mouse atlases to model early primate development.

See Ton, Keitley et al.

Bharathan et al. discover that the ER associates with keratin intermediate filaments and desmosomal cell–cell junctions and show that desmosomes and the keratin cytoskeleton regulate ER network distribution and function.

See Bharathan et al. and News & Views by Gottardi

Epidermal injury elicits the priming of distant memory progenitors that have not contributed to original healing but acquire enhanced repair abilities, favouring field cancerization.

See Levra Levron et al. and News & Views by Lyko

Sensory bristles co-opt neighbouring epidermal cells, which adopt a special morphology and contribute to touch sensing in "Drosophila.

See Mangione et al. and News & Views by Jan

Adriaenssens et al. report that cytosolic small heat shock proteins localize to the mitochondrial intermembrane space, where they operate as molecular chaperones.

See Adriaenssens et al.

Complementary studies from Gao et al. and Lu et al. show that ETV6 represses the transcriptional activity of the EWS–FLI1 fusion protein during the development of Ewing sarcoma, uncovering a transcriptional mechanism that promotes cancer.

See Gao et al., the related Lu et al. and News & Views by Lawlor

PD-1 signalling defines a population of leukaemia stem cells with features of quiescence, drug resistance and protection against cell death, ablation of which suppresses disease progression of mouse and human lymphoblastic leukaemia.

See Xu et al. and News & Views by Suda