Volume 22 Issue 2, February 2020

Volume 22 Issue 2

RNA

piRNAs regulate fertility via epigenetic silencing

See Barucci et al..

Image: [Image courtesy of Eric Cornes, Institut Pasteur, Paris]. Cover Design: [Lauren Heslop].

News & Views

  • News & Views |

    A mechanism of secretory autophagy explains aspects of the packaging of proteins and RNA into extracellular vesicles and paves the way to a better understanding of their biological roles and medical applications.

    • Janusz Rak
  • News & Views |

    Understanding the metabolic rewiring of pancreatic ductal adenocarcinoma is an emerging strategy for identifying cancer-associated liabilities and improving treatment. A new study now elucidates the function of the transaminase BCAT2 in the early stages of tumor development, providing insights that could stimulate novel therapeutic strategies.

    • Mattia Falcone
    •  & Oliver D. K. Maddocks
  • News & Views |

    The ribosome decodes messenger RNAs and constructs proteins based on the genetic blueprint. Ribosomes also associate with non-coding RNAs, such as PIWI-interacting RNA (piRNA) precursors, during the meiotic pachytene stage. Intriguingly, the ribosome mediates pachytene piRNA biogenesis by guiding endonucleolytic cleavage of piRNA precursors.

    • Yuanhui Mao
    •  & Shu-Bing Qian

Perspectives

Letters

  • Letter |

    Gaglia et al. show, using single-cell imaging and analysis in human tumours, that phase transition of heat-shock factor 1 (HSF1) to form intranuclear stress bodies mediates cell-fate decisions underlying cell survival or death.

    • Giorgio Gaglia
    • , Rumana Rashid
    • , Clarence Yapp
    • , Gaurav N. Joshi
    • , Carmen G. Li
    • , Susan L. Lindquist
    • , Kristopher A. Sarosiek
    • , Luke Whitesell
    • , Peter K. Sorger
    •  & Sandro Santagata
  • Letter |

    Lee et al. show that, after nitrogen starvation and genetic interference with the architecture of nuclear pore complexes, nucleoporins are degraded by autophagy, constituting a quality-control step at the nuclear envelope.

    • Chia-Wei Lee
    • , Florian Wilfling
    • , Paolo Ronchi
    • , Matteo Allegretti
    • , Shyamal Mosalaganti
    • , Stefan Jentsch
    • , Martin Beck
    •  & Boris Pfander
  • Letter |

    Li et al. show that BCAA transaminase 2 enhances uptake and catabolism of branched-chain amino acids, thereby promoting development of pancreatic ductal adenocarcinoma harbouring KRAS mutations.

    • Jin-Tao Li
    • , Miao Yin
    • , Di Wang
    • , Jian Wang
    • , Ming-Zhu Lei
    • , Ye Zhang
    • , Ying Liu
    • , Lei Zhang
    • , Shao-Wu Zou
    • , Li-Peng Hu
    • , Zhi-Gang Zhang
    • , Yi-Ping Wang
    • , Wen-Yu Wen
    • , Hao-Jie Lu
    • , Zheng-Jun Chen
    • , Dan Su
    •  & Qun-Ying Lei

Articles

  • Article |

    Hu, Tan, Chia et al. identify negative elongation factor A as one of the earliest drivers of the mouse embryonic 2-cell-like state through interaction with Top2a, which mediates Dux expression.

    • Zhenhua Hu
    • , Dennis Eng Kiat Tan
    • , Gloryn Chia
    • , Haihan Tan
    • , Hwei Fen Leong
    • , Benjamin Jieming Chen
    • , Mei Sheng Lau
    • , Kelly Yu Sing Tan
    • , Xuezhi Bi
    • , Dongxiao Yang
    • , Ying Swan Ho
    • , Baojiang Wu
    • , Siqin Bao
    • , Esther Sook Miin Wong
    •  & Wee-Wei Tee
  • Article |

    Leidal et al. show that the LC3-conjugation pathway, which is part of the autophagy machinery, controls extracellular vesicle cargo loading and secretion of RNA-binding proteins.

    • Andrew M. Leidal
    • , Hector H. Huang
    • , Timothy Marsh
    • , Tina Solvik
    • , Dachuan Zhang
    • , Jordan Ye
    • , FuiBoon Kai
    • , Juliet Goldsmith
    • , Jennifer Y. Liu
    • , Yu-Hsin Huang
    • , Teresa Monkkonen
    • , Ariadne Vlahakis
    • , Eric J. Huang
    • , Hani Goodarzi
    • , Li Yu
    • , Arun P. Wiita
    •  & Jayanta Debnath
  • Article |

    Sun et al. uncover a conserved mechanism by which ribosomes function in defining the position of pachytene piRNA formation on long single-stranded RNAs during spermatogenesis.

    • Yu H. Sun
    • , Jiang Zhu
    • , Li Huitong Xie
    • , Ziwei Li
    • , Rajyalakshmi Meduri
    • , Xiaopeng Zhu
    • , Chi Song
    • , Chen Chen
    • , Emiliano P. Ricci
    • , Zhiping Weng
    •  & Xin Zhiguo Li
  • Article |

    Solinger et al. show that FERARI is a conserved tethering platform that mediates Rab11-dependent recycling at sorting endosomes.

    • Jachen A. Solinger
    • , Harun-Or Rashid
    • , Cristina Prescianotto-Baschong
    •  & Anne Spang
  • Article |

    Lee et al. show that energy stress inhibits ferroptosis through AMPK activation and demonstrate a role for AMPK in ferroptosis-associated renal ischaemia–reperfusion injury in vivo.

    • Hyemin Lee
    • , Fereshteh Zandkarimi
    • , Yilei Zhang
    • , Jitendra Kumar Meena
    • , Jongchan Kim
    • , Li Zhuang
    • , Siddhartha Tyagi
    • , Li Ma
    • , Thomas F. Westbrook
    • , Gregory R. Steinberg
    • , Daisuke Nakada
    • , Brent R. Stockwell
    •  & Boyi Gan
  • Article |

    The Hippo and mTORC1 pathways regulate growth control for proper organ development. Here, Gan et al. find that the Hippo pathway kinases LATS1 and LATS2 phosphorylate the mTORC1 component Raptor to attenuate mTORC1 activation.

    • Wenjian Gan
    • , Xiaoming Dai
    • , Xiangpeng Dai
    • , Jun Xie
    • , Shasha Yin
    • , Junjie Zhu
    • , Chen Wang
    • , Yuchen Liu
    • , Jianping Guo
    • , Min Wang
    • , Jing Liu
    • , Jia Hu
    • , Ryan J. Quinton
    • , Neil J. Ganem
    • , Pengda Liu
    • , John M. Asara
    • , Pier Paolo Pandolfi
    • , Yingzi Yang
    • , Zhigang He
    • , Guangping Gao
    •  & Wenyi Wei

Amendments & Corrections