The ribosome decodes messenger RNAs and constructs proteins based on the genetic blueprint. Ribosomes also associate with non-coding RNAs, such as PIWI-interacting RNA (piRNA) precursors, during the meiotic pachytene stage. Intriguingly, the ribosome mediates pachytene piRNA biogenesis by guiding endonucleolytic cleavage of piRNA precursors.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The birth of piRNAs: how mammalian piRNAs are produced, originated, and evolved
Mammalian Genome Open Access 01 November 2021
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Ozata, D. M., Gainetdinov, I., Zoch, A., O’Carroll, D. & Zamore, P. D. Nat. Rev. Genet. 20, 89–108 (2019).
Lewis, S. H. et al. Nat. Ecol. Evol. 2, 174–181 (2018).
Seto, A. G., Kingston, R. E. & Lau, N. C. Mol. Cell 26, 603–609 (2007).
Li, X. Z. et al. Mol. Cell 50, 67–81 (2013).
Brennecke, J. et al. Cell 128, 1089–1103 (2007).
Mohn, F., Handler, D. & Brennecke, J. Science 348, 812–817 (2015).
Han, B. W., Wang, W., Li, C., Weng, Z. & Zamore, P. D. Science 348, 817–821 (2015).
Watanabe, T. et al. Dev. Cell 20, 364–375 (2011).
Grivna, S. T., Pyhtila, B. & Lin, H. Proc. Natl. Acad. Sci. USA 103, 13415–13420 (2006).
Sun, Y. H. & Li, X. Z. Nat. Cell Biol. https://doi.org/10.1038/10.1038/s41556-019-0457-4 (2020).
Ransohoff, J. D., Wei, Y. & Khavari, P. A. Nat. Rev. Mol. Cell Biol. 19, 143–157 (2018).
Vourekas, A. et al. Genes Dev. 29, 617–629 (2015).
Ding, D. et al. Nat. Commun. 9, 127 (2018).
Gou, L. T. et al. Cell Res. 24, 680–700 (2014).
Ibrahim, F., Maragkakis, M., Alexiou, P. & Mourelatos, Z. Nat. Struct. Mol. Biol. 25, 302–310 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Mao, Y., Qian, SB. Ribosome-guided piRNA production. Nat Cell Biol 22, 141–142 (2020). https://doi.org/10.1038/s41556-020-0464-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-020-0464-5