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Volume 20 Issue 3, March 2018

Volume 20 Issue 3

Organelles

Isolating intact mitochondria from specific cells shows that the Caenorhabditis elegans germline propagates deleterious mitochondrial genomes.

See Ahier et al.

Image: Nick Valmas and Steven Zuryn, University of Queensland. Cover Design: Lauren Heslop.

Editorial

  • Editorial |

    Autophagy is a cellular degradation and recycling process with complex roles in health and disease and emerging relevance to translational research. In this issue, we launch a Series of commissioned articles that will discuss recent advances and outstanding questions driving this rapidly expanding and diverse field.

Research Highlights

News & Views

  • News & Views |

    Inflammation and reactive oxygen species (ROS) production after central nervous system injury are thought to enhance tissue damage and hamper neuronal regeneration. Evidence now suggests that NADPH2 oxidase delivery from macrophages to injured neurons through extracellular vesicles, promotes ROS signalling and axon recovery.

    • Eva-Maria Krämer-Albers
  • News & Views |

    Cytoplasmic flows are essential for various cellular processes. However, tools to manipulate these flows within cells are still lacking. Now research shows that an optical tool allows for control of cytoplasmic flows and can be used as a subcellular rheometer.

    • Karsten Kruse
    • Nicolas Chiaruttini
    • Aurélien Roux
  • News & Views |

    Exosomes are heterogeneous, nanoscale vesicles that mediate cellular communication. A study now leverages a size separation strategy to identify sub-classes of nanoparticles, revealing a subtype without an encapsulating membrane and variation in vesicle cargo, suggesting that size is not the only driver of heterogeneity.

    • Andries Zijlstra
    • Dolores Di Vizio
  • News & Views |

    N6-methyladenosine (m6A) mRNA modification influences mRNA fate by stimulating recruitment of m6A reader proteins. A previously unappreciated class of m6A reader proteins is now shown to use a common RNA-binding domain and flanking regions to selectively bind m6A-containing mRNAs, increasing their translation and stability.

    • Katherine I. Zhou
    • Tao Pan

Review Articles

  • Review Article |

    In this Review Article, Klionsky and co-authors discuss selective autophagy pathways that degrade unwanted cytosolic components and organelles, and how these pathways require ligand receptors and scaffold proteins for cargo specificity.

    • Damián Gatica
    • Vikramjit Lahiri
    • Daniel J. Klionsky
  • Review Article |

    Autophagy and cancer: In this Review, Galluzzi and colleagues discuss the cellular and molecular mechanisms whereby autophagy functions in multiple aspects of malignant disease, including cancer initiation, progression and responses to therapy.

    • Marissa D. Rybstein
    • José Manuel Bravo-San Pedro
    • Lorenzo Galluzzi

Articles

Resources

Technical Reports

Amendments & Corrections

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