Volume 12 Issue 9, September 2010

Volume 12 Issue 9

Five specially commissioned articles highlight recent advances in autophagy research.


  • Editorial |

    Autophagy targets portions of cytoplasm, damaged organelles and proteins for lysosomal degradation and has crucial roles in development and disease. This issue presents a series of specially commissioned articles that highlight recent developments and emerging themes in this area.




News and Views

  • News & Views |

    Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.

    • Jeremy D. Rotty
    • , Gerald W. Hart
    •  & Pierre A. Coulombe
  • News & Views |

    Kinetochores link microtubules to DNA and provide force critical for chromosome segregation in mitosis. New data show that kinetochores are not necessary for acentrosomal meiotic chromosome segregation in Caenorhabditis elegans. Instead, CLS-2 (CLASP) generates a mid-zone bundle of microtubules that are suggested to act in pushing the chromosomes apart.

    • Xue Han
    •  & Martin Srayko

Research Highlights


  • Article |

    The role of different histone H3 variants following mouse fertilization has not been addressed. The histone H3.3, and its Lys 27 are involved in the establishment of paternal heterochromatin in the pericentric region of the mouse early embryo, through a mechanism involving dsRNA.

    • Angèle Santenard
    • , Céline Ziegler-Birling
    • , Marc Koch
    • , Làszlò Tora
    • , Andrew J. Bannister
    •  & Maria-Elena Torres-Padilla
  • Article |

    Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) lead to accumulation of proteins aggregates in airways. Mutated CFTR promotes transglutaminases-mediated crosslinking of beclin 1, a positive regulator of autophagy, to induce accumulation of LC3-binding protein p62 and prevent autophagic degradation of aggregates.

    • Alessandro Luciani
    • , Valeria Rachela Villella
    • , Speranza Esposito
    • , Nicola Brunetti-Pierri
    • , Diego Medina
    • , Carmine Settembre
    • , Manuela Gavina
    • , Laura Pulze
    • , Ida Giardino
    • , Massimo Pettoello-Mantovani
    • , Maria D'Apolito
    • , Stefano Guido
    • , Eliezer Masliah
    • , Brian Spencer
    • , Sonia Quaratino
    • , Valeria Raia
    • , Andrea Ballabio
    •  & Luigi Maiuri



  • Focus |

    Focus on Autophagy

    Autophagy targets damaged organelles and proteins for lysosomal degradation. This potent degradation mechanism has crucial roles in development, immune defence, programmed cell death, tumour suppression, neurodegeneration and stress response. The September 2010 issue of Nature Cell Biologypresents a series of specially commissioned Reviews, Perspectives and Commentaries highlighting new insights into this process.