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In this Review, Hustedt and Durocher discuss recent advances in our understanding of how different repair pathways, in particular double-strand break repair, are regulated across the cell cycle to ensure faithful segregation of the genome.
Passegué and colleagues discuss recent advances in our understanding of the metabolic control of stem cell function, and how stem cell metabolism relates to homeostasis and ageing.
Sanchez and Dynlacht discuss recent insights into the mechanisms of primary cilia assembly and disassembly, and the relationships between ciliogenesis and cell cycle regulation as well as disease.
Yau and Rape discuss recent advances in our understanding of the many variations in ubiquitin chain topology and how these mediate ubiquitin-dependent signalling in the cell.
Sander and colleagues discuss recent evidence for and against the roles of stem cells versus the plasticity of mature cell types in response to injury during regeneration of the adult liver and pancreas.
Barker and colleagues review the history and recent developments of organoid cultures derived from pluripotent stem cells and adult epithelia, and discuss how the technology can be used for basic research as well as translational applications.
