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Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.
Donati et al. show that following skin wounding a differentiated Gata6+ cell population resident in the sebaceous duct migrates to the interfollicular epidermis and reattaches to the basal membrane, dedifferentiating into stem cells.
Decker et al. show that leptin-receptor-positive mesenchymal stromal cells are the source of the fibrogenic myofibroblasts that expand in primary myelofibrosis in a process mediated by PDGFRA pathway activation.
Tavernier et al. show that loss of the protective IRE1–XBP1 stress sensor results in the death of conventional dendritic cells in the lung, whereas those in the intestine survive due to a stronger ATF4-dependent stress response and RIDD activation.
Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
Jiang et al. show that the microcephaly-associated protein ASPM and katanin form a complex that binds microtubule minus ends and can sever microtubules and block microtubule minus-end elongation to control spindle pole dynamics.
Cha et al. show that SIRT2 suppression by miR-200c enhances acetylation levels and enzymatic activities of glycolytic enzymes and contributes to metabolic reprogramming of human induced pluripotent stem cells and human embryonic stem cells.
Sah and colleagues show that the volume-sensitive ion channel SWELL1 regulates adipocyte insulin-PI(3)K-AKT2 signalling, glucose uptake and lipid content through interactions with GRB2/Cav1.
Reilein et al. demonstrate that Drosophila ovarian follicle stem cells (FSCs) produce either proliferative follicle cells or quiescent escort cells, depending on which position they occupy in the germarium and in response to graded Wnt signalling.
Fujita et al. find that normal epithelial cells induce metabolic changes in adjacent transformed cells, causing their apical extrusion. The effect is conveyed non-cell-autonomously and relies on PDK4-mediated inhibition of mitochondrial function.
Adding to the recent debate on the role of epithelial–mesenchymal transition (EMT) in cancer cell invasion and metastasis, Brabletz and colleagues show that the EMT-inducing transcription factor Zeb1 drives pancreatic tumorigenesis and metastasis.
Damm et al. demonstrate that trunk neural crest cell migration to the dorsal aorta in zebrafish is regulated by platelet-derived growth factor (PDGF) signalling and required for haematopoietic stem cell (HSC) specification.
The Cdc45–MCM–GINS (CMG) complex is needed for DNA replication, but how CMG dissociates from DNA in higher eukaryotes is not clear. Sonneville et al. now characterize pathways for CMG dissociation and replication termination in worm and frog.
Chatzinikolaou et al. show that the nucleotide excision repair complex ERCC1–XPF cooperates with the chromatin organizer CTCF, cohesin subunits and ATRX to facilitate the silencing of a subset of imprinted genes in the developing liver.
Miao et al. show through imaging and mathematical simulations that changing the activation thresholds in an excitable PIP2–Ras–Rap signal transduction network can alter the types of protrusions formed in migrating Dictyostelium cells.
Zebrafish neuroectoderm morphogenesis is influenced by the mesoderm germ layer. Smutny et al. now show that friction forces between cells moving in opposite directions, mediated by E-cadherin adhesion, determine the position of the neural anlage.
Zhang et al. show that YAP and TAZ suppress nucleic acid sensing and antiviral responses by inhibiting the TBK1 kinase. Conversely, Hippo pathway activity inactivates YAP/TAZ to relieve TBK1 suppression and enhance antiviral defence in zebrafish.
Using large-scale, super-resolution microscopy, Sochacki et al. define the spatial organization of 19 proteins within clathrin-coated pits during distinct stages of clathrin-mediated endocytosis.
Donato et al. show that Fbxo15 targets acetylated KBP for degradation to limit mitochondrial expansion, whereas KBP accumulation promotes mitochondrial biogenesis in a Kif1Bα-dependent manner.
Velten et al. use single-cell transcriptomics and functional data to map the early lineage commitment of human haematopoietic stem cells as a continuous process of cells passing through transitory states rather than demarcating discrete progenitors.