Volume 38 Issue 5, May 2020

Editorial

All that’s fit to preprint

COVID-19 has reinforced the importance of preprints as an indispensable means for rapid research dissemination.

Editorial 05 May 2020

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News

Cancer-eating immune cells kitted out with CARs

Immunotherapy startups look to engineer macrophages to fight solid tumors.

Elie Dolgin
News 11 May 2020
Biggest COVID-19 trial tests repurposed drugs first

News in Brief 11 May 2020
Active machine learning helps drug hunters tackle biology

A growing cadre of startups is pursuing iterative cycles of machine learning, wet-lab experimentation and human feedback to accelerate target drug discovery.

Michael Eisenstein
News 11 May 2020
First drug approved for neurofibromas is a MEK inhibitor

News in Brief 11 May 2020
Drug-induced protein degradation heats up

News in Brief 11 May 2020
Fast, portable tests come online to curb coronavirus pandemic

Testing kits delivered by courier and digital tools combine to battle the COVID-19 outbreak.

Cormac Sheridan
News 23 Mar 2020
Around the world in a month

News in Brief 11 May 2020
Data Page
- Drug pipeline 1Q20
  
  Laura DeFrancesco
  Data Page 11 May 2020
- 1Q20 — biotech stocks nosedive
  
  Laura DeFrancesco
  Data Page 11 May 2020
News Feature
- The pandemic pipeline
  
  Companies are doing their best to accelerate experimental drugs and vaccines for COVID-19 through the pipeline. Each faces its own set of challenges, but all agree on the need for a radical rethink of the clinical development process for pandemics.
  
  John Hodgson
  
  Milestone:
  
  Nature Milestones in Vaccines
  News Feature 20 Mar 2020

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Bioentrepreneur

Building a Business
- In conversation with four startup CEOs
  
  A cadre of biotech leaders discuss lessons learned from the bioentrepreneur experience.
  
  Brady Huggett
  Building a Business 15 Apr 2020

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Correspondence

Access and benefit-sharing following the synthesis of horsepox virus

Michelle F. Rourke
Alexandra Phelan
Charles Lawson
Correspondence 22 Apr 2020

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Comment

Developing therapeutic monoclonal antibodies at pandemic pace

The time from discovery to proof-of-concept trials could be reduced to 5–6 months from a traditional timeline of 10–12 months.

Brian Kelley
Comment 21 Apr 2020

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Features

Nature Biotechnology’s academic spinouts of 2019

Our annual survey highlights startups tackling intractable viruses with new vaccine design, engineering a reliable source of platelets, universalizing cell therapies, improving cancer screening, developing RNA-editing platforms and targeting protein–RNA interactions. Michael Eisenstein, Ken Garber, Caroline Seydel and Laura DeFrancesco report.

Michael Eisenstein
Ken Garber
Laura DeFrancesco

Nature Outlook:

The Spinoff Prize 2021
Feature 23 Apr 2020
Patents
- Adapting the ordre public and morality exclusion of European patent law to accommodate emerging technologies
  
  Patent law’s existing public policy exclusion should be reinterpreted and a new method introduced for assessing the moral and public policy implications of commercializing emerging technologies.
  
  Justine Pila
  Patents 11 May 2020
- Epigenetic drugs
  
  Recent patents for pharmaceutical compounds comprising and treatments using histone deacetylase and DNA methyltransferase inhibitors.
  
  Patents 11 May 2020

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News & Views

Diamonds in the doublets

Interacting cells are characterized by sequencing FACS clusters.

Sean C. Bendall
News & Views 21 Apr 2020

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Research

Perspectives
- Viral contamination in biologic manufacture and implications for emerging therapies
  
  The Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB) provides a comprehensive and forward-looking overview of industry’s experience with viral contamination of cell cultures used to produce recombinant proteins.
  
  Paul W. Barone
  Michael E. Wiebe
  Stacy L. Springs
  Perspective 27 Apr 2020
Matters Arising
- Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes
  
  Max A. Horlbeck
  S. John Liu
  Jonathan S. Weissman
  Matters Arising 24 Feb 2020
- Reply to: Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes
  
  Ying Liu
  Zhiheng Liu
  Wensheng Wei
  Matters Arising 24 Feb 2020
Brief Communications
- Superior field performance of waxy corn engineered using CRISPR–Cas9
  
  Gene-edited waxy corn lines have higher yields in field trials than hybrids produced by traditional trait introgression.
  
  Huirong Gao
  Mark J. Gadlage
  R. Bob Meeley
  Brief Communication 09 Mar 2020
- Prime genome editing in rice and wheat
  
  Prime editors are optimized for use in plants.
  
  Qiupeng Lin
  Yuan Zong
  Caixia Gao
  
  Special:
  
  SCGE
  Brief Communication 16 Mar 2020
Letters
- Multiplex digital spatial profiling of proteins and RNA in fixed tissue
  
  A turnkey system allows for spatial profiling of proteins and RNA in fixed tissues, providing a window on cellular heterogeneity.
  
  Christopher R. Merritt
  Giang T. Ong
  Joseph M. Beechem
  Letter 11 May 2020
Articles
- Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm
  
  Nematode bacterial symbionts were evolved in vitro to resist insect-sequestered plant toxins to improve the insect-killing efficacy of their nematode host.
  
  Ricardo A. R. Machado
  Lisa Thönen
  Matthias Erb
  Article 17 Feb 2020
- Massively parallel interrogation and mining of natively paired human TCRαβ repertoires
  
  T cell receptors are identified in large-scale screening of T cell repertoires cloned from primary human T cells.
  
  Matthew J. Spindler
  Ayla L. Nelson
  David S. Johnson
  Article 16 Mar 2020
- Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors
  
  Methods to efficiently detect Cas9-independent cytosine base editor off-target activity enable the identification and development of variants with minimal off-target editing and robust on-target editing.
  
  Jordan L. Doman
  Aditya Raguram
  David R. Liu
  
  Special:
  
  SCGE
  Article 10 Feb 2020
- Dissecting cellular crosstalk by sequencing physically interacting cells
  
  PIC-seq characterizes cellular crosstalk by sorting and sequencing physically interacting cells.
  
  Amir Giladi
  Merav Cohen
  Ido Amit
  
  Collection:
  
  Stromal–immune cell interactions
  Article 09 Mar 2020
- Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform
  
  Combining Cas9 and Cas12a outperforms previous approaches for combinatorial screening in mammalian cells.
  
  Thomas Gonatopoulos-Pournatzis
  Michael Aregger
  Jason Moffat
  Article 16 Mar 2020

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Amendments & Corrections

Author Correction: Reply to: Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes

Ying Liu
Zhiheng Liu
Wensheng Wei
Author Correction 09 Mar 2020
Publisher Correction: Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm

Ricardo A. R. Machado
Lisa Thönen
Matthias Erb
Publisher Correction 12 Mar 2020
Publisher Correction: γδ T cells bring unconventional cancer-targeting to the clinic — again

Ken Garber
Publisher Correction 21 Apr 2020
Publisher Correction: Single-cell RNA-seq analysis software providers scramble to offer solutions

Michael Eisenstein
Publisher Correction 15 Apr 2020

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Careers & Recruitment

Career Feature
- First-quarter biotech job picture
  
  A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 11 May 2020
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 11 May 2020

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Volume 38 Issue 5, May 2020

Western corn rootworm biocontrol

Editorial

News

Data Page

News Feature

Bioentrepreneur

Building a Business

Correspondence

Comment

Features

Patents

News & Views

Research

Perspectives

Matters Arising

Brief Communications

Letters

Articles

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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