Volume 38 Issue 11, November 2020

Editorial

Preparing for the vaccine

Clear and consistent messaging on COVID-19 vaccine rollout will be key to building public trust and managing expectations.

Editorial 27 Oct 2020

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News

IRAK4 degrader to take on innate immunity

Interest in anti-inflammatory IRAK4 signaling is ramping up, as small-molecule ‘degraders’ that bind both the kinase and E3 ubiquitin ligases prepare to take on traditional kinase inhibitors.

Asher Mullard
News 03 Nov 2020
10x Genomics sequences in situ

News in Brief 03 Nov 2020
First video game to treat disease gains FDA okay

The prescription-only game is said to improve attention function in children with attention deficit hyperactivity disorder (ADHD).

Emily Waltz
News 03 Nov 2020
Big pharma buys into exosomes for drug delivery

Several pharmaceutical companies are placing big bets on exosomes and other extracellular vesicles as a means to deliver nucleic acid therapeutics.

Mark Zipkin
News 03 Nov 2020
Illumina wants Grail back

News in Brief 03 Nov 2020
Doudna’s Scribe unveils

News in Brief 03 Nov 2020
Around the world in a month

News in Brief 03 Nov 2020
Data Page
- Drug pipeline 3Q20
  
  Laura DeFrancesco
  Data Page 03 Nov 2020
- 3Q20 — good times roll on
  
  Laura DeFrancesco
  Data Page 03 Nov 2020

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Correspondence

Animal-free alternatives and the antibody iceberg

Alison Gray
Andrew R. M. Bradbury
Stefan Dübel
Correspondence 12 Oct 2020
A novel computational architecture for large-scale genomics

Matthias Becker
Hartmut Schultze
Joachim L. Schultze
Correspondence 30 Sept 2020

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Q&A

COVID-19 antibodies on trial

With the first readouts of trials of antibodies against COVID-19 appearing and others coming thick and fast, Nature Biotechnology asked a group of experts to comment on the challenges and timelines for these products.

Laura DeFrancesco
Q&A 21 Oct 2020

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Features

Patents
- A qualitative study of biosimilar manufacturer and regulator perceptions on intellectual property and abbreviated approval pathways
  
  Abbreviated regulatory approval pathways for biosimilars were created to accommodate intellectual property protection, foster competition and lower drug prices, but their success in achieving these goals has been mixed.
  
  Louise C. Druedahl
  Anna Birna Almarsdóttir
  Ameet Sarpatwari
  Patents 03 Nov 2020
- Single-cell analysis and microfluidics
  
  Recent patents related to microfluidic devices and methods for single-cell analysis.
  
  Patents 03 Nov 2020

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News & Views

Podcast
- Forum: Bioengineered scaffolds repair the uterus in rabbits
  
  Podcast 13 Jul 2020

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Research

Matters Arising
- Lactate measurements in an integrated perfusion machine for human livers
  
  Barney T. F. Stephenson
  Simon C. Afford
  Darius F. Mirza
  Matters Arising 26 Oct 2020
- Viability criteria assessment during liver machine perfusion
  
  Isabel M. A. Brüggenwirth
  Vincent E. de Meijer
  Paulo N. Martins
  Matters Arising 26 Oct 2020
- Reply to: Lactate measurements in an integrated perfusion machine for human livers
  
  Philipp Dutkowski
  Matteo Mueller
  Pierre-Alain Clavien
  Matters Arising 26 Oct 2020
Letters
- Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient
  
  Patterning of the human neural tube is modeled in a microfluidic device.
  
  Pedro Rifes
  Marc Isaksson
  Agnete Kirkeby
  
  Collection:
  
  Stem cells from development to the clinic
  Letter 25 May 2020
- A GRF–GIF chimeric protein improves the regeneration efficiency of transgenic plants
  
  A method to increase plant regeneration efficiency extends gene editing to more species and genotypes.
  
  Juan M. Debernardi
  David M. Tricoli
  Jorge Dubcovsky
  Letter 12 Oct 2020
Articles
- A tissue-engineered uterus supports live births in rabbits
  
  The rabbit uterus is reconstructed using synthetic scaffolds seeded with cells.
  
  Renata S. Magalhaes
  J. Koudy Williams
  Anthony Atala
  Article 29 Jun 2020
- Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis
  
  Gut microbiome composition is remodeled using small peptides.
  
  Poshen B. Chen
  Audrey S. Black
  M. Reza Ghadiri
  
  Collections:
  
  Chemical Biology of Microbiomes
  
  Diet, microbiome and immune homeostasis
  Article 15 Jun 2020
- Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking
  
  Transient p53 inhibition and induced cell-cycle progression increase clonal engraftment and homology-directed repair in hematopoietic stem cells.
  
  Samuele Ferrari
  Aurelien Jacob
  Luigi Naldini
  Article 29 Jun 2020
- Automated assembly of centromeres from ultra-long error-prone reads
  
  CentroFlye resolves tandem repeats to assemble human centromeres from nanopore reads.
  
  Andrey V. Bzikadze
  Pavel A. Pevzner
  Article 14 Jul 2020
- CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity
  
  The genome-wide activity of Cas9 is measured in unprecedented detail.
  
  Cicera R. Lazzarotto
  Nikolay L. Malinin
  Shengdar Q. Tsai
  
  Special:
  
  SCGE
  Article 15 Jun 2020
- Prediction of the sequence-specific cleavage activity of Cas9 variants
  
  Deep-learning models predict the Cas9 variant with optimal activity and specificity for any target sequence.
  
  Nahye Kim
  Hui Kwon Kim
  Hyongbum Henry Kim
  Article 08 Jun 2020
- Rapid image deconvolution and multiview fusion for optical microscopy
  
  Microscopy datasets are processed orders-of-magnitude faster with improved algorithms and deep learning.
  
  Min Guo
  Yue Li
  Hari Shroff
  Article 29 Jun 2020
Resources
- A robust benchmark for detection of germline large deletions and insertions
  
  Detection of structural variants in the human genome is facilitated by a benchmark set of large deletions and insertions.
  
  Justin M. Zook
  Nancy F. Hansen
  Marc Salit
  Resource 15 Jun 2020

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Amendments & Corrections

Author Correction: Multiplexed droplet single-cell RNA-sequencing using natural genetic variation

Hyun Min Kang
Meena Subramaniam
Chun Jimmie Ye
Author Correction 14 Oct 2020
Author Correction: A robust benchmark for detection of germline large deletions and insertions

Justin M. Zook
Nancy F. Hansen
Marc Salit
Author Correction 22 Jul 2020
Publisher Correction: Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient

Pedro Rifes
Marc Isaksson
Agnete Kirkeby
Publisher Correction 11 Jun 2020
Publisher Correction: Antibody engineers seek optimal drug targeting TIGIT checkpoint

Elie Dolgin
Publisher Correction 30 Sept 2020

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Careers & Recruitment

Career Feature
- Third-quarter biotech job picture
  
  A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 03 Nov 2020
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 03 Nov 2020

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Volume 38 Issue 11, November 2020

Live births from bioengineered wombs

Editorial

News

Data Page

Correspondence

Q&A

Features

Patents

News & Views

Podcast

Research

Matters Arising

Letters

Articles

Resources

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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