Volume 37 Issue 5, May 2019

On the sixth anniversary of Mayo v. Prometheus, what impact has the US Supreme Court decision had on patent subject-matter eligibility and the prosecution of biotech-related patent applications before the US Patent and Trademark Office?

Recent patents related to metagenomic analysis for compound identification and sequence assembly.

An antibody–drug conjugate targeting HER2 is acid-switched to increase its antitumor efficacy.

A single-gene-encoded monomeric IgA protects piglets from enterotoxic E. coli infection.

A cell-based sensor detects tumors with higher sensitivity than protein and nucleic acid biomarkers.

Flye improves the speed and accuracy of genome assembly by using repeat graphs to resolve repeat regions.

The authors comprehensively benchmark the accuracy, scalability, stability and usability of 45 single-cell trajectory inference methods.

A new standard allows the accuracy of variant calls to be assessed and compared across different technologies, variant types and genomic regions.

Genome in a Bottle Consortium presents a high-confidence dataset for benchmarking small variant calls in human genomes.

A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.

A sample of goings-on in and around the biotech and pharmaceutical industry.