Volume 37 Issue 4, April 2019

Realizing the dream of noninvasive glucose monitoring

A deep dive into the influence of research output, patenting, venture capital and human capital on startup financing activity in Europe reveals not all countries are equal.

An analysis of published patent applications in chimeric antigen receptor (CAR) T-cell immunotherapy allows insight into the development of this emerging technology.

Recent patents related to wearable devices and systems for monitoring glucose levels and other health conditions.

Assessing progress towards designing reliable wearable biosensors reveals the challenges remaining before the promise of clinical translation can be realized.

Heikenfeld et al. survey the range of biochemical analytes that can be sensed in dermal interstitial fluid, saliva and sweat, and outline criteria for tailoring sensor design to address the right analyte in the right body site for the right disease or wellness application.

SignalP 5.0 improves proteome-wide detection of signal peptides across all organisms and can distinguish between different types of signal peptides in prokaryotes.

A new method using mild chemical reactions and enzymatic oxidation allows nondestructive sequencing of 5-methylcytosine and 5-hydroxymethylcytosine with base-level resolution.

Unbiased detection of off-target editing by adenine base editors in vitro uncovers differences in the specificity patterns of adenine and cytosine base editors, and of unmodified Cas9.

Supplying forebrain organoids with a developmental signaling gradient induces topographical patterning along dorso-ventral and antero-posterior axes.

Homology-directed DNA repair using RNA as a template enables precise gene replacement in rice.

Palantir uses single-cell RNA-seq data to generate continuous models of differentiation, infer developmental trajectories, and calculate the probabilities of cell fate choices.

A new computational method allows key developmental checkpoints and important parameters of population dynamics to be inferred from single-cell RNA-sequencing time series data.

A string-based computational tool enables swift, robust identification of post-translational modifications in MS/MS datasets.

A report by the Coalition of State Bioscience Institutes details the US life science industry’s workforce needs and what it must do to maintain its competitive advantage in the worldwide market.

A sample of goings-on in and around the biotech and pharmaceutical industry.