Volume 32 Issue 2, February 2014

Volume 32 Issue 2

A more detailed and comprehensive analysis of the immune system will reveal basic and translational insights and may lead to development of new therapeutic strategies. In this month’s joint Focus with Nature Immunology, featured articles describe the new technologies and computational approaches that enable this sort of high-dimensional characterization of components of the immune system. www.nature.com/focus/ high_dimensional_immune_analysis Artwork by Lewis Long.


  • Editorial |

    In an effort to rein in costs and galvanize its discovery effort, Merck is following the industry vogue for externalizing early-stage R&D. Is it going to cast its net far and wide enough?


News Feature

  • News Feature |

    Despite an overall dip in FDA approvals of new chemical and biologic entities, 2013 wasn't a bad year for innovator drugs. Jim Kling reports.

    • Jim Kling

Data Page



News & Views


  • Editorial |

    Emerging technologies are broadening our understanding of the human immune system, but capitalizing on their application will likely require philosophical and practical changes to the way research is done.


Review Article


Brief Communication


  • Article |

    Synergistic cancer therapies SMAC mimetic compounds synergize with oncolytic viruses and other innate immune stimuli to promote tumor cell death.

    • Shawn T Beug
    • , Vera A Tang
    • , Eric C LaCasse
    • , Herman H Cheung
    • , Caroline E Beauregard
    • , Jan Brun
    • , Jeffrey P Nuyens
    • , Nathalie Earl
    • , Martine St-Jean
    • , Janelle Holbrook
    • , Himika Dastidar
    • , Douglas J Mahoney
    • , Carolina Ilkow
    • , Fabrice Le Boeuf
    • , John C Bell
    •  & Robert G Korneluk
  • Article |

    Bispecifics by orthogonal interfaces To improve correct antibody heavy-light chain pairing during bispecific antibody assembly, Lewis et al. design antibody heavy and light chains with orthogonal interfaces.

    • Steven M Lewis
    • , Xiufeng Wu
    • , Anna Pustilnik
    • , Arlene Sereno
    • , Flora Huang
    • , Heather L Rick
    • , Gurkan Guntas
    • , Andrew Leaver-Fay
    • , Eric M Smith
    • , Carolyn Ho
    • , Christophe Hansen-Estruch
    • , Aaron K Chamberlain
    • , Stephanie M Truhlar
    • , Elaine M Conner
    • , Shane Atwell
    • , Brian Kuhlman
    •  & Stephen J Demarest

Careers and Recruitment

In This Issue


  • Focus |

    High-dimensional analysis of the immune system

    New technologies enable analysis of the extraordinarily diverse and polymorphic components of the immune system–especially the human immune system–at a level of unprecedented detail. Reviews and a Commentary specially commissioned by Nature Biotechnology and Nature Immunology discuss these new methodologies, and how they may be applied to track immune status in health and disease, as well as to reveal new basic immunological insight. A Correspondence describing an initiative to design tools and resources to facilitate these high-dimensional analyses is also included.