Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Discovery and saturation analysis of cancer genes across 21 tumour types

Lawrence, M.S. et al. Nature doi:10.1038/nature12912 (5 January 2014)

Rewiring yeast sugar transporter preference through modifying a conserved protein motif

Young, E.M. et al. PNAS 111, 131–136 (2014)

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas sysem

Chen, B. et al. Cell 155, 1479–1491 (2014)

Genome-scale CRISPR-Cas9 knockout screening in human cells

Shalem, O. et al. Science 343, 84–87 (2014)

Genetic screens in human cells using the CRISPR-Cas9 system

Wang, T. et al. Science 343, 80–84 (2014)