Volume 32 Issue 10, October 2014

Volume 32 Issue 10

An artistic rendition of stabilized antibody-drug conjugates in the blood. Lyon et al. describe a linker chemistry that increases the stability and efficacy of antibody-drug conjugates in vivo (p 1059). Credit: Kenneth Eward

Editorial

  • Editorial |

    Drug delivery research requires an injection of new thinking. Fostering closer ties with cell biologists seeking to unravel membrane trafficking is a good place to start.

News

Bioentrepreneur

Correspondence

Commentary

  • Commentary |

    Big pharma's storehouse of trouble has fostered consumer mistrust and a negative view of the industry. How does the industry go about restoring its flagging reputation?

    • Mark Kessel

Feature

  • Feature |

    Monoclonal antibodies continue their march on the markets, optimized so-called biobetter versions of existing biologics are also gaining ground, but the rate of biosimilar approvals has seen a dramatic slowdown in recent years.

    • Gary Walsh

Patents

News & Views

  • News & Views |

    Guidelines for determining sequencing depth facilitate transcriptome profiling of single cells in heterogeneous populations.

    • Aaron M Streets
    •  & Yanyi Huang
  • News & Views |

    Research on converting one cell type to another will be aided by systematic mapping of the gene-regulatory networks in mammalian cells.

    • Avi Ma'ayan
    •  & Qiaonan Duan
  • News & Views |

    A breakthrough in wireless power transfer enables smaller implantable devices, opening the door to new applications.

    • Henry Mei
    •  & Pedro P Irazoqui

Analysis

  • Analysis |

    An elegant mathematical model supported by experiments in Escherichia coli demonstrates how clustering enzymes can efficiently channel intermediates from one enzyme to the next, facilitating rational engineering of metabolism.

    • Michele Castellana
    • , Maxwell Z Wilson
    • , Yifan Xu
    • , Preeti Joshi
    • , Ileana M Cristea
    • , Joshua D Rabinowitz
    • , Zemer Gitai
    •  & Ned S Wingreen

Article

  • Article |

    Chromatin crosslinking facilitates the detection in selected genomic regions of structural variants missed by existing approaches

    • Paula J P de Vree
    • , Elzo de Wit
    • , Mehmet Yilmaz
    • , Monique van de Heijning
    • , Petra Klous
    • , Marjon J A M Verstegen
    • , Yi Wan
    • , Hans Teunissen
    • , Peter H L Krijger
    • , Geert Geeven
    • , Paul P Eijk
    • , Daoud Sie
    • , Bauke Ylstra
    • , Lorette O M Hulsman
    • , Marieke F van Dooren
    • , Laura J C M van Zutven
    • , Ans van den Ouweland
    • , Sjef Verbeek
    • , Ko Willems van Dijk
    • , Marion Cornelissen
    • , Atze T Das
    • , Ben Berkhout
    • , Birgit Sikkema-Raddatz
    • , Eva van den Berg
    • , Pieter van der Vlies
    • , Desiree Weening
    • , Johan T den Dunnen
    • , Magdalena Matusiak
    • , Mohamed Lamkanfi
    • , Marjolijn J L Ligtenberg
    • , Petra ter Brugge
    • , Jos Jonkers
    • , John A Foekens
    • , John W Martens
    • , Rob van der Luijt
    • , Hans Kristian Ploos van Amstel
    • , Max van Min
    • , Erik Splinter
    •  & Wouter de Laat
  • Article |

    Coupling limited proteolysis and a proteomics workflow enables measurement of both subtle and wholesale protein conformational changes in a eukaryotic proteome.

    • Yuehan Feng
    • , Giorgia De Franceschi
    • , Abdullah Kahraman
    • , Martin Soste
    • , Andre Melnik
    • , Paul J Boersema
    • , Patrizia Polverino de Laureto
    • , Yaroslav Nikolaev
    • , Ana Paula Oliveira
    •  & Paola Picotti
  • Article | | Open Access

    Sequencing and de novo assembly of seven wild relatives of soybean yields insights relevant to crop domestication and improvement.

    • Ying-hui Li
    • , Guangyu Zhou
    • , Jianxin Ma
    • , Wenkai Jiang
    • , Long-guo Jin
    • , Zhouhao Zhang
    • , Yong Guo
    • , Jinbo Zhang
    • , Yi Sui
    • , Liangtao Zheng
    • , Shan-shan Zhang
    • , Qiyang Zuo
    • , Xue-hui Shi
    • , Yan-fei Li
    • , Wan-ke Zhang
    • , Yiyao Hu
    • , Guanyi Kong
    • , Hui-long Hong
    • , Bing Tan
    • , Jian Song
    • , Zhang-xiong Liu
    • , Yaoshen Wang
    • , Hang Ruan
    • , Carol K L Yeung
    • , Jian Liu
    • , Hailong Wang
    • , Li-juan Zhang
    • , Rong-xia Guan
    • , Ke-jing Wang
    • , Wen-bin Li
    • , Shou-yi Chen
    • , Ru-zhen Chang
    • , Zhi Jiang
    • , Scott A Jackson
    • , Ruiqiang Li
    •  & Li-juan Qiu

Letter

Careers and Recruitment