Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts

Bredenkamp, N. et al. Nat. Cell Biol. 16, 902–908 (2014)

Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity

Bournazos, S. et al. Cell 158, 1243–1253 (2014)

Clonal evolution in breast cancer revealed by single nucleus genome sequencing

Wang, Y. et al. Nature 512, 155–160 (2014)

Optogenetic neuronal stimulation promotes functional recovery after stroke

Cheng, M.Y. et al. Proc. Natl. Acad. Sci. USA 111, 12913–12918 (2014)

Epigenetic manipulation restores functions of defective CD8 + T cells from chronic viral infection

Zhang, F. et al. Mol. Ther. 22, 1698–1706 (2014)