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CRISPR-Cas9 can be used to edit both single and multiple genes in postmitotic neurons in adult mice enabling rapid assessment of gene functions in the brain.
Analysis of the genome editing activity of more than 1800 sgRNAs in mouse and human cells yields rules to facilitate design of highly active RNA guides for Cas-9 genome editing.
TALEN-induced mutation of all homologous copies of a gene that represses resistance to an important wheat pathogen confers a trait that has eluded plant breeders for decades.
Laszlo et al. demonstrate sequence alignment, and proof-of-concept organism identification, genome assembly and polymorphism detection from nanopore analysis of natural DNA.