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Volume 612 Issue 7941, 22 December 2022

One year. Ten stories.

As 2022 enters its final weeks, we look back on the past 12 months through the lens of Nature’s 10 — ten people who helped to shape science during the year. The cover takes its inspiration from the stunning images that have so far emerged from the James Webb Space Telescope. Launched on Christmas Day 2021, the telescope sent its first image back to Earth this summer and has since provided astronomers with views of the Universe in unprecedented detail.

Cover image: Melissa Weiss/

This Week

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News in Focus

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  • Feature

    • Cost-of-living crises, labour shortages and the impact of global politics on research collaborations were among the challenges faced by working scientists in a tumultuous year.

      • Chris Woolston
      Career Feature
  • Where I Work

    • Conservationist Eileen Maher uses large spheres made of shells, sand and cement to prevent erosion and attract oysters as part of her work to manage tidelands around a Southern Californian port.

      • Kendall Powell
      Where I Work
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  • News & Views

    • Microorganisms in the gut produce molecules that activate sensory neurons, stimulating exercise-associated reward circuits in the brain. This newly discovered pathway in mice affects motivation for prolonged exercise.

      • Gulistan Agirman
      • Elaine Y. Hsiao
      News & Views
    • The therapeutic options available to treat ovarian cancer need improvement. Data that reveal the cellular, molecular and mutational landscape as such tumours grow and spread might aid efforts to develop new targeted therapies.

      • Denarda Dangaj Laniti
      • George Coukos
      News & Views
    • What are the ecological consequences of logging in a tropical forest? A detailed assessment of vegetation growth, bird and mammal numbers, and energy flows in logged and unlogged forests offers some surprising findings.

      • Pieter A. Zuidema
      • Joeri A. Zwerts
      News & Views
    • Future LEDs could be based on lead halide perovskites. A breakthrough in preparing device-compatible solids composed of nanoscale perovskite crystals overcomes a long-standing hurdle in making blue perovskite LEDs.

      • Hendrik Utzat
      • Maria Ibáñez
      News & Views
    • Assessment of a tumour’s mutational profile offers a way of predicting a person’s response to anticancer therapies called immune-checkpoint inhibitors. It seems that such approaches might fall short for people who are not of European ancestry.

      • Chao Cheng
      • Christopher I. Amos
      News & Views
    • An X-ray imaging mission has unveiled the magnetic field in the environment of a dead star. The order and symmetry of the field will reshape our understanding of how it accelerates particles to ultra-high energies.

      • Samar Safi-Harb
      News & Views
  • Reviews

    • Recent key developments in the exploration of kagome materials are reviewed, including fundamental concepts of a kagome lattice, realizations of Chern and Weyl topological magnetism, flat-band many-body correlations, and unconventional charge-density waves and superconductivity.

      • Jia-Xin Yin
      • Biao Lian
      • M. Zahid Hasan
      Review Article
  • Articles

    • Polarization can exceed 60% at the leading edge of the inner part of the Vela pulsar wind nebula; in contrast with the case of the supernova remnant, the electrons in the pulsar wind nebula are accelerated with little or no turbulence in a highly uniform magnetic field.

      • Fei Xie
      • Alessandro Di Marco
      • Silvia Zane
    • Optomechanical lattices in one and two dimensions with exceptionally low disorder are realized, showing how the optomechanical interaction can be exploited for direct measurements of the Hamiltonian, beyond the tight-binding approximation.

      • Amir Youssefi
      • Shingo Kono
      • Tobias J. Kippenberg
    • An efficient and scalable direct seawater electrolysis method for hydrogen production that addresses the side-reaction and corrosion problems associated with using seawater instead of pure water is demonstrated.

      • Heping Xie
      • Zhiyu Zhao
      • Zongping Shao
    • Ultrasmall monodisperse perovskite quantum dots are synthesized in situ on a substrate via ligand structure regulation, yielding the highest external quantum efficiency blue perovskite LEDs reported so far.

      • Yuanzhi Jiang
      • Changjiu Sun
      • Mingjian Yuan
    • An additive manufacturing technique that infuses 3D printed hydrogels with metallic precursors leads to metallic micromaterials, providing new opportunities for the fabrication of energy materials, micro-electromechanical systems and biomedical devices.

      • Max A. Saccone
      • Rebecca A. Gallivan
      • Julia R. Greer
    • Measurements of  isomerization rates  of CO isotopologues on an NaCl surface show a nonmonotonic mass dependence that arises from  resonantly enhanced cross-barrier coupling, or ‘tunnelling gateways’, which  are intrinsic to condensed-phase tunnelling.

      • Arnab Choudhury
      • Jessalyn A. DeVine
      • Alec M. Wodtke
      Article Open Access
    • Analysis of new observations from the EUREC4A field campaign shows that lower-tropospheric mixing does not desiccate the base of trade cumulus clouds, refuting the mixing-desiccation hypothesis and explaining the weak trade cumulus feedback.

      • Raphaela Vogel
      • Anna Lea Albright
      • Sandrine Bony
      Article Open Access
    • Analysis of Landsat imagery from the past two decades allows quantification of the changes in salt marsh ecosystems, as well as associated carbon emissions resulting from net global losses.

      • Anthony D. Campbell
      • Lola Fatoyinbo
      • David Lagomasino
      Article Open Access
    • Logged forests in Borneo have higher energy flow from vegetation to and broad range of bird and mammal species relative to old-growth forests and oil palm plantations, showing that they can be diverse and ecologically vibrant ecosystems.

      • Yadvinder Malhi
      • Terhi Riutta
      • Matthew J. Struebig
      Article Open Access
    • Provora is an ancient supergroup of microbial predators that are genetically, morphologically and behaviourally distinct from other eukaryotes, and comprise two divergent clades of predators—Nebulidia and Nibbleridia—that differ fundamentally in ultrastructure, behaviour and gene content.

      • Denis V. Tikhonenkov
      • Kirill V. Mikhailov
      • Patrick J. Keeling
    • RibosomeST—a ribosome with a specialized nascent polypeptide exit tunnel—cotranslationally regulates the folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm.

      • Huiling Li
      • Yangao Huo
      • Jiahao Sha
    • In-depth transcriptomic analyses of 56,636 single cells from monkey embryos revealed transcriptional features of major perigastrulation cell types, and comparative analyses with mouse embryos and human embryoids uncovered conserved and divergent features of perigastrulation development across species.

      • Jinglei Zhai
      • Jing Guo
      • Hongmei Wang
      Article Open Access
    • It is demonstrated that the brain circuitry involved in regulating the motivation for physical activity is not strictly central nervous system autonomous but is shaped by peripheral influences that originate in the intestinal microbial community.

      • Lenka Dohnalová
      • Patrick Lundgren
      • Christoph A. Thaiss
    • Cell-specific respiration rates differ by more than 1,000× among prokaryoplankton genera, and the majority of respiration was found to be performed by minority members of prokaryoplankton, whereas cells of the most prevalent lineages had extremely low respiration rates.

      • Jacob H. Munson-McGee
      • Melody R. Lindsay
      • Ramunas Stepanauskas
      Article Open Access
    • Multi-modal analysis of genomically unstable ovarian tumours characterizes the contribution of anatomical sites and mutational processes to evolutionary phenotypic divergence and immune resistance mechanisms.

      • Ignacio Vázquez-García
      • Florian Uhlitz
      • Sohrab P. Shah
      Article Open Access
    • Integrated single-cell atlases of human fetal cerebella and MBs show potential cell populations predisposed to transformation and regulatory circuitries underlying tumour cell states and oncogenesis, highlighting hitherto unrecognized transitional progenitor intermediates predictive of disease prognosis.

      • Zaili Luo
      • Mingyang Xia
      • Q. Richard Lu
    • Mutations in the sodium/iodide symporter (NIS) cause congenital hypothyroidism, and our results yield insights into how NIS selects, couples and translocates anions, thereby establishing a framework for understanding NIS function.

      • Silvia Ravera
      • Juan Pablo Nicola
      • Nancy Carrasco
  • Matters Arising

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Amendments & Corrections

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  • Most parents want to protect their children from the variety of illnesses and experiences that can occur in the early years of life.

    Nature Outlook
  • Here’s how to plan a scientific conference that’s safe and inclusive for all.

    Career Guide
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