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Volume 560 Issue 7718, 16 August 2018

Rolling clones

The cover image shows a number of marbles rolling down a slope. Much like the cell lines they represent, these marbles all look superficially similar, but on closer examination those farther down the slope are showing changes in their internal patterning, which reflect the results found in this week’s issue by Todd Golub and his colleagues. Looking at cancer cell lines, the researchers show that far from being clonal, the cell line ‘strains’ display differences in genomic alterations, gene-expression profiles, proliferation rates and drug response, all of which arise as a result of genetic and transcriptional evolution. Their findings have implications for cancer research using such cell lines and the team has created a publicly available online tool called Cell STRAINER to help assess cell-line divergence.

Cover image: Iris Fung with contributions from Andrew Tubelli, Bang Wong and Uri Ben-David

This Week

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News in Focus

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  • Time to publish.

    • J. W. Armstrong
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  • News & Views

    • Catalysts working in pairs can promote more-effective reactions than can the same catalysts used sequentially. The coupling of an enzyme with a light-activated catalyst offers great potential for organic synthesis.

      • Nicholas J. Turner
      News & Views
    • Humans perceive colours in categories such as red, even though we can discern red hues including ruby and crimson. It emerges that birds also categorize colours and this affects their colour-discrimination ability.

      • Almut Kelber
      News & Views
    • RNA sequencing of single cells in the mammalian trachea reveals a previously unknown airway cell that expresses genes involved in fluid and solute balance, and that might play a part in cystic fibrosis.

      • Kyle J. Travaglini
      • Mark A. Krasnow
      News & Views
    • Neutrinos are tiny, ghost-like particles that habitually change identity. A measurement of the rate of change in high-energy neutrinos racing through Earth provides a record-breaking test of Einstein’s special theory of relativity.

      • Matthew Mewes
      News & Views
    • Genome-editing approaches have been used to fuse 16 yeast chromosomes to produce yeast strains with only 1 or 2 chromosomes. Surprisingly, this fusion has little effect on cell fitness.

      • Gianni Liti
      News & Views
  • Articles

  • Letters

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Amendments & Corrections

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