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Volume 497 Issue 7448, 9 May 2013


  • Editorial |

    The US Supreme Court should overturn the 2003 law that requires federally funded HIV/AIDS programmes abroad to denounce prostitution.

  • Editorial |

    Federal regulators could learn much from California’s low-carbon fuel programme.

  • Editorial |

    Confidence is rising among scientists defending animal research. It should be encouraged.

World View

Research Highlights

Seven Days

  • Seven Days |

    The week in science: Somali famine death toll estimated, mental disorders redefined, and coronavirus cases on the rise.



News Feature


  • Comment |

    Researchers trying to work out whether global warming will cause more wars need to stop fighting and work together, urges Andrew R. Solow.

    • Andrew R. Solow
  • Comment |

    Draconian access requirements are squandering the potential of imaging technology to advance human palaeontology, cautions Jean-Jacques Hublin.

    • Jean-Jacques Hublin

Books & Arts



News & Views Forum

  • News & Views Forum |

    The elusive pear shapes of certain nuclei, which are challenging to predict theoretically, have at last been measured precisely. Two experts offer their views on what the results mean for nuclear physics and particle physics. See Article p.199

    • C. J. (Kim) Lister
    • Jonathan Butterworth

News & Views

  • News & Views |

    Detection of the trace neutral fraction of hydrogen gas that stretches between the nearby Andromeda and Triangulum galaxies has allowed resolved spectral imaging of this elusive intergalactic medium. See Letter p.224

    • Robert Braun
  • News & Views |

    At last, the crystal structure is revealed for the catalytically active mTOR kinase enzyme, a master regulator of cell growth. The structure indicates a gatekeeper mechanism that controls substrate access to the active site. See Article p.217

    • Dario R. Alessi
    • Yogesh Kulathu
  • News & Views |

    In a finding that could have implications for vaccine design, memory immune cells at mucosal surfaces have been shown to respond to encounters with pathogens by issuing signals that recruit other memory cells to the site.

    • Jennifer E. Smith-Garvin
    • Luis J. Sigal
  • News & Views |

    Fusion of muscle cells called myoblasts underlies the generation and maintenance of skeletal muscle throughout an animal's life. Emerging data indicate that cell death acts as a signal to enhance these processes in mammals. See Letter p.263

    • Shannon F. Yu
    • Mary K. Baylies
  • News & Views |

    Inflammation-activated signalling pathways in the brain's hypothalamus control the production of ageing-related hormones. This finding provides a link between inflammation, stress responses and systemic ageing. See Article p.211

    • Dana Gabuzda
    • Bruce A. Yankner


  • Article |

    An experimental study of certain short-lived isotopes of radon and radium has found clear octupole deformation in the nuclei of the latter — that is, these nuclei are pear-shaped; the results enable discrimination between differing theoretical approaches to octupole correlations.

    • L. P. Gaffney
    • P. A. Butler
    • M. Zielinska
  • Article |

    Motor patterns underlying the rodent exploratory behaviours whisking and sniffing are coordinated by respiratory centres in the ventral medulla; a distinct region in the ventral medulla provides rhythmic input to the facial motor neurons that drive scanning by the vibrissae, and input from the pre-Bötzinger complex coordinates whisking with sniffing and basal breathing.

    • Jeffrey D. Moore
    • Martin Deschênes
    • David Kleinfeld
  • Article |

    Activation of IKK-β and NF-κB in the hypothalamus of mice is shown to accelerate the ageing process, leading to shortened lifespan; inhibition of hypothalamic or brain IKK-β and NF-κB delays ageing and increases lifespan, and NF-κB activation results in a reduction of GnRH levels, whereas NF-κB inhibition leads to GnRH-induced neurogenesis to mediate ageing retardation.

    • Guo Zhang
    • Juxue Li
    • Dongsheng Cai
  • Article |

    Co-crystal structures of a number of complexes involving truncated mammalian target of rapamycin, a phosphoinositide 3-kinase-related protein kinase, reveal an intrinsically active kinase conformation and show how rapamycin–FKBP12 directly blocks substrate recruitment to the kinase domain.

    • Haijuan Yang
    • Derek G. Rudge
    • Nikola P. Pavletich


  • Letter |

    The non-Fermi-liquid regime that emerges in MnSi under high pressures displays a Hall signal that can be traced to topologically non-trivial spin configurations at low pressures — a well-understood skyrmion lattice — empirically suggesting a route towards a breakdown of Fermi liquid theory in pure metals.

    • R. Ritz
    • M. Halder
    • C. Pfleiderer
  • Letter |

    M-CSF, a myeloid cytokine released during infection and inflammation, instructs myeloid lineage fate in single haematopoietic stem cells by directly inducing PU.1, a known myeloid lineage master regulator; this shows that specific cytokines can act directly on haematopoietic stem cells to instruct a change of cell identity.

    • Noushine Mossadegh-Keller
    • Sandrine Sarrazin
    • Michael H. Sieweke
  • Letter |

    This study shows that Dis3l2 is the 3′–5′ exonuclease that mediates the degradation of uridylated precursor let-7 microRNA; this is the first physiological RNA substrate identified for this new exonuclease, which causes the Perlman syndrome of fetal overgrowth and Wilms’ tumour susceptibility when mutated.

    • Hao-Ming Chang
    • Robinson Triboulet
    • Richard I. Gregory
  • Letter |

    The neonatal heart has a high regenerative capacity that is lost in adult life; the transcription factor Meis1 has been identified as a relevant proliferative switch for this transition, providing a potential therapeutic target for adult heart regeneration.

    • Ahmed I. Mahmoud
    • Fatih Kocabas
    • Hesham A. Sadek
  • Letter |

    By using high-throughput sequencing of T-cell receptors, this study shows that thymus-derived regulatory T (Treg) cells constitute most Treg cells in all lymphoid and intestinal organs, including the colon, suggesting that thymic Treg cells and not induced Treg cells dominantly control tolerance to the gut’s antigens such as commensal microbiota.

    • Anna Cebula
    • Michal Seweryn
    • Leszek Ignatowicz
  • Letter |

    The crystal structure of a nucleotide-free energy-coupling factor transporter from Lactobacillus brevis at a resolution of 3.5 Å suggests a plausible working model for the transport cycle of such transporters.

    • Tingliang Wang
    • Guobin Fu
    • Yigong Shi


Career Brief

  • Career Brief |

    US adjuncts need to know whether they qualify for Obamacare, says education union.

  • Career Brief |

    Report calls for schemes to boost student exchanges across Europe.



  • Q&A |

    Lack of a PhD has not hindered researcher's zeal for resurrecting the extinct passenger pigeon.

    • Virginia Gewin


  • Futures |

    How to save the Universe.

    • Sylvia Spruck Wrigley
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