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Structural biology

Security measures of a master regulator

Nature volume 497, pages 193–194 (2013)Cite this article

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At last, the crystal structure is revealed for the catalytically active mTOR kinase enzyme, a master regulator of cell growth. The structure indicates a gatekeeper mechanism that controls substrate access to the active site. See Article p.217

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Figure 1: mTOR simplified.

Notes

  1. *This article and the paper under discussion were published online on 1 May 2013.

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Authors and Affiliations

  1. Dario R. Alessi and Yogesh Kulathu are at the MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.,

    Dario R. Alessi & Yogesh Kulathu

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  1. Dario R. Alessi
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  2. Yogesh Kulathu
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Correspondence to Dario R. Alessi or Yogesh Kulathu.

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Alessi, D., Kulathu, Y. Security measures of a master regulator. Nature 497, 193–194 (2013). https://doi.org/10.1038/nature12101

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