Eukaryotic chromosomes are confined to the nucleus, which is separated from the rest of the cell by a membrane called the nuclear envelope. Within this envelope are protein-lined channels known as nuclear-pore complexes, through which cellular material is transported into and out of the nucleus. A study now links this to chromosomes, showing that the three-dimensional organization of chromosomes is provided, in part, by interactions with the nuclear pore complex.
- Wai-Hong Tham
- Virginia A. Zakian