Reviews & Analysis

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  • Structural insights into a long-studied folate-transport protein provide evidence that might lead to entirely new targeted anticancer treatments, or boost the success of immunotherapy approaches to tackling tumours.

    • Larry H. Matherly
    • Zhanjun Hou
    News & Views
  • Radiation from a jet of ultrafast particles powered by a supermassive black hole suggests that the particles are accelerated by shock waves propagating along the jet, making them shine with the brightness of 100 billion Suns.

    • Lea Marcotulli
    News & Views
  • Mounting evidence suggests that developing neurons and metastatic cancer cells migrate through similar mechanisms. Characterization of a previously unknown complex involved in cell migration confirms this idea.

    • Alain Chédotal
    News & Views
  • A theory shows that active agents can cooperate in the presence of disorder — a result that could inform the design of robots that organize on rough surfaces, or show how cells migrate en masse.

    • Sam Cameron
    • Tannie Liverpool
    News & Views
  • People who carry a particular variant of the APOE gene are at increased risk of developing Alzheimer’s disease. It emerges that this might be due to decreased production of a fatty substance called myelin by oligodendrocyte cells.

    • Karl Carlström
    • Gonçalo Castelo-Branco
    News & Views
  • Bacteria are frequently present in human cancers. The use of state-of-the-art methods for tumour analysis that capture spatial information and single-cell molecular profiles paves the way to clarifying the roles of these microorganisms.

    • Ilana Livyatan
    • Ravid Straussman
    News & Views
  • A 30-year record of ocean-current velocities has been used to infer wind speeds during tropical cyclones. The data show that these storms have intensified over time, supporting claims that their strength will increase as the planet warms.

    • Robert L. Korty
    News & Views
  • Existing telecommunications infrastructure could operate as a miniaturized global positioning system, offering submetre resolution in urban areas and indoors, where location information from satellites is often inaccurate.

    • Hui Chen
    • Henk Wymeersch
    News & Views
  • The discovery of a gene that mediates periodic segmentation of the developing backbone of vertebrate embryos opened up research into how the pace of development is controlled by a molecular clock that has a species-specific rhythm.

    • Ryoichiro Kageyama
    News & Views
  • Molecules of heavy water contain the deuterium isotope of hydrogen and have been impossible to separate from ordinary water. Nanoporous materials with flexible apertures in their structures point the way to a solution.

    • Thomas Heine
    • Randall Q. Snurr
    News & Views
  • The generation of spatial maps that detail molecular and genetic information for the diverse cells and tissue environment of breast tumours offers insight into the factors that drive cancer progression.

    • Ghamdan Al-Eryani
    • Alexander Swarbrick
    News & Views
  • A clever application of perception-altering technology, enabled by genetic manipulations, provides insight into how fruit flies follow tendrils of airborne odour plumes to localize the source of smells.

    • Floris van Breugel
    • Bingni W. Brunton
    News & Views
  • Improved treatments for spinal-cord injury require both technological development and insights into the biology of recovery. High-resolution molecular maps of the nervous system are beginning to provide the latter.

    • Kee Wui Huang
    • Eiman Azim
    News & Views
  • A fluid of ultracold atoms has exhibited quantum dynamics similar to those thought to have existed moments after the Big Bang — ushering in a new era of laboratory exploration of the early Universe.

    • Silke Weinfurtner
    News & Views
  • In an effort to treat systemic lupus erythematosus, T cells of the immune system were engineered to become cells known as CAR T cells. Their injection into people with the disease resulted in clinical and immunological improvement.

    • George C. Tsokos
    News & Views
  • Sediment records from Alaska, spanning the past 20,000 years, suggest that melting glaciers triggered volcanic episodes that removed oxygen in the northeastern Pacific Ocean, explaining ‘dead zones’ that lasted millennia.

    • Weiqi Yao
    • Ulrich G. Wortmann
    News & Views
  • Predicting the risk of extinction from climate change requires an understanding of the interactions between species. An analysis of how changes in rainfall affect competition between plant species offers a way of tackling this challenge.

    • Ellen I. Damschen
    News & Views