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Two studies reveal that early-life malfunction in organelles called mitochondria brings about lasting changes in how DNA is packaged. These alterations have consequences for cellular stress responses and organismal longevity.
Decoded and precisely dated information encrypted in stalagmites from a cave in China reveal past climatic changes and provide insight into the complex interactions in today's climate system. See Letter p.640
A study reveals that human-driven disturbances in previously undisturbed Amazon rainforest can cause biodiversity losses as severe as those of deforestation. Urgent policy interventions are needed to preserve forest quality. See Letter p.144
The protein PKM-ζ has been proposed to regulate the maintenance of memory in rodents, but this theory has been questioned. The finding that another isoform of the protein acts as a backup if PKM-ζ is lacking will influence this debate.
At what times of year are phenological events across species sensitive to climatic variables, and how sensitive are they? Answers to these questions emerge from the analysis of a wealth of long-term data sets. See Article p.241
The role of Ki-67 in mitotic cell division has been a mystery. Extensive imaging reveals that this highly positively charged protein coats chromosomes to prevent them from coalescing. See Letter p.308
The objective of the Paris climate agreement is to limit global-average temperature increase to well below 2 degrees Celsius above pre-industrial levels and to further pursue limiting it to 1.5 degrees Celsius; here, the adequacy of the national plans submitted in preparation for this agreement is assessed, and it is concluded that substantial enhancement or over-delivery on these plans is required to have a reasonable chance of achieving the Paris climate objective.
A range of neuronal mechanisms can enable animals to detect the direction of visual motion. Computational models now indicate that a factor as simple as eye size might explain some of this diversity. See Article p.105
Gauge theories underpin the standard model of particle physics, but are difficult to study using conventional computational methods. An experimental quantum system opens up fresh avenues of investigation. See Letter p.516
The detection of a gravitational wave was a historic event that heralded a new phase of astronomy. A numerical model of the Universe now allows researchers to tell the story of the black-hole system that caused the wave. See Letter p.512
In some species, cancer cells can be directly transmitted between individuals. An analysis in shellfish now shows that some transmissible cancers can even cross the species barrier. See Letter p.705
Advances in meson spectroscopy can enhance our understanding of how composite objects emerge from the fundamental underlying theory of interacting quarks and gluons, quantum chromodynamics.
Communication between cells relies on hormone release from secretory granules, but how these vesicles fuse with cell membranes is unclear. An imaging study provides in vivo evidence for a stable intermediate fusion step. See Letter p.548
An analysis suggests that high carbon uptake by US land ecosystems during the warm spring of 2012 offset the carbon loss that resulted from severe drought over the summer — and hints that the warm spring could have worsened the drought.
Sperm–egg binding is mediated by two cell-surface proteins. Structural analysis of these proteins separately and in complex provides insight into the recognition process and the subsequent sperm–egg fusion. See Letters p.562 & p.566
An in-depth analysis of a close relative of animals, Capsaspora owczarzaki, provides clues to the changes in gene regulation that occurred during the transition to multicellularity.
Interactions in the gut between host cells and bacteria can determine a state of health or disease. A study investigates how antibiotic treatment can affect host cells in a way that drives growth of pathogenic bacteria. See Letter p.697
A multiscale model has been implemented that provides accurate predictions of the behaviour of ferroelectric materials in electric fields, and might aid efforts to design devices such as sensors and digital memory. See Letter p.360
The bacteria that inhabit the rodent gut promote insulin secretion and food intake by activating the parasympathetic nervous system — a hitherto unknown mode of action for this multifaceted microbiota. See Article p.213
Two molecular motors have been developed that use chemical energy to drive rotational motion in a single direction. The findings bring the prospect of devices powered by such motors a tantalizing step closer. See Letter p.235