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Directional solidification of a simple AgCl-KCl lamellar eutectic material is modified by the presence of a pillar template, leading to disordered, trefoil, quatrefoil, cinquefoil and hexafoil mesostructures.
In a mouse model of glioblastoma, treatment with VEGF-C increases lymphatic drainage in the central nervous system and improves the immune response, suggesting that modulating meningeal lymphatics could enhance checkpoint inhibitor therapy.
Bacteria and archaea use cyclic oligoadenylate molecules as part of the CRISPR system for antiviral defence; here, a family of viral enzymes that rapidly degrades cyclic oligoadenylates is identified and biochemically and structurally described.
The Galactic Centre is orbited by two objects that look like gas and dust clouds but behave more like stars, and now four additional similar objects are reported.
AlphaFold predicts the distances between pairs of residues, is used to construct potentials of mean force that accurately describe the shape of a protein and can be optimized with gradient descent to predict protein structures.
The nonlinearity of hopping conduction in a disordered network of boron dopant atoms in silicon is used to perform nonlinear classification and feature extraction.
Single-cell RNA sequencing is used to catalogue and explore the developmental trajectories of more than 30,000 cells in the developing human hippocampus.
Analyses of single-cell recordings from mouse ventral tegmental area are consistent with a model of reinforcement learning in which the brain represents possible future rewards not as a single mean of stochastic outcomes, as in the canonical model, but instead as a probability distribution.
The use of alternating-current electric fields to control domain size in ferroelectric crystals affords excellent transparency, piezoelectricity and birefringence.
Human presomitic mesoderm cells derived in vitro demonstrate oscillations of the segmentation clock, thus providing a window into an otherwise inaccessible stage of human development.
An integrated analysis of several cohorts shows that clonal, antigen-experienced T cells are found in the cerebrospinal fluid of patients with Alzheimer’s disease, suggesting that the adaptive immune system has a role in age-related neurodegeneration.
Monitoring cells of the mouse presomitic mesoderm using the Achilles reporter fused to HES7 sheds light on the mechanisms that underpin synchronous oscillations in the expression of clock genes between neighbouring cells.
The structure of GLP-1R and its G protein in complex with the small molecule TT-OAD2 sheds light on how the TT-OAD2 agonist can activate the receptor and provides insights into the development of therapeutic agents for metabolic disorders.
Neonatal mice are protected against infection with the enteric pathogen enterotoxigenic Escherichia coli by maternally derived natural antibodies as well as by maternal commensal microbiota that induce antibodies that recognize antigens expressed by Enterobacteriaceae.
A reconstruction of permafrost dynamics using speleothems from a Siberian cave indicates that Siberian permafrost is robust to warming when Arctic sea ice is present, but vulnerable when it is absent.
A new method for analysing change in high-dimensional data is based on nearest-neighbour statistics and is applied here to song dynamics during vocal learning in zebra finches, but could potentially be applied to other biological and artificial behaviours.
The synthesis of surprisingly stable, free-standing single layers of amorphous carbon and their analysis by atomic-resolution imaging could settle a debate about their atomic arrangement and offer unusual electronics applications.