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Heterozygous mutateons in the caspase-8 cleavage site of RIPK1 cause a range of autoinflammatory symptoms in humans, and caspase-8 cleavage of RIPK1 in a mouse model limits TNF-induced cell death and inflammation.
Three techniques for estimating mass losses from the Greenland Ice Sheet produce comparable results for the period 1992–2018 that approach the trajectory of the highest rates of sea-level rise projected by the IPCC.
In oxygen-redox intercalation cathodes, voltage hysteresis can be avoided by forming cathode materials with a ‘ribbon’ superstructure in the transition metal layers that suppresses transition metal migration.
The worldwide distribution and water supply of water towers (snowy or glacierized mountain ranges) is indexed, showing that the most important water towers are also the most vulnerable to socio-economic and climate-change stresses, with huge potential negative impacts on populations downstream.
The jumbo phage ΦKZ constructs a proteinaceous nucleus-like compartment around its genome that protects phage DNA from degradation by DNA-targeting immune effectors of the host, including CRISPR–Cas and restriction enzymes.
Data collected by the Parker Solar Probe in the solar corona are used to determine the organization of Alfvén waves, revealing an increasing flow velocity peaking at 35–50 km s−1.
The Parker Solar Probe mission has reached the inner heliosphere of the Sun and made measurements of energetic particle events in the near-Sun radiation environment.
precisely controllable integrated optical gyroscope based on stimulated Brillouin scattering is used to study non-Hermitian physics, revealing a four-fold enhancement of the Sagnac scale factor near exceptional points.
Observations of the solar corona by the Parker Solar Probe reveal evidence for the predicted dust-free zone and confirm that streamers comprise smaller substreamers that channel continuous multiscale density fluctuations.
A method based on non-Hermitian singularities, or exceptional points, is established and used to increase the Sagnac scale factor and enhance the sensitivity of ring-laser gyroscopes.
Titanium–copper alloys with fully equiaxed grains and a fine microstructure are realized via an additive manufacturing process that exploits high cooling rates and multiple thermal cycles.
Frontal cortex neurons can be grouped into categorical response types corresponding to particular decision variables, such as reward size, decision confidence, or value, and individual variables may be encoded in distinct projection populations; this suggests that, like neurons in sensory cortex, frontal neurons form a sparse and overcomplete representation of important variables in the environment.
Analyses of primary and relapse samples of embryonal tumours with multilayered rosettes provide insights into the molecular mechanisms that underlie the development and opportunities for the treatment of this deadly disease.
RITF1, a newly identified plant transcription factor, links signalling through the peptide hormone RGF1 to the balance of reactive oxygen species and thereby enhances the stability of another transcription factor, PLETHORA2, a master regulator of root stem cells.
Using whole-genome sequencing data from 1,739 individuals, the GenomeAsia 100K Project catalogues genetic variation, population structure and disease associations to facilitate genetic studies in Asian populations and increase representation in genetics studies worldwide.
Anoxygenic photosynthetic microorganisms can biomineralize manganese oxides without molecular oxygen being present and without high-potential photosynthetic reaction centres, which sheds doubt on proposed dates for the origins of oxygenic photosynthetic metabolism.
The emergence of a liquid-like electronic flow from ballistic flow in graphene is imaged, and an almost-ideal viscous hydrodynamic fluid of electrons exhibiting a parabolic Poiseuille flow profile is observed.
Chaperones interact with a canonical motif in α-synuclein, which can be prevented by phosphorylation of α-synuclein at Tyr39, whereas inhibition of this interaction leads to the localization of α-synuclein to the mitochondria and aggregate formation.
A subpopulation of Caenorhabditis elegans, in which there is a naturally occurring transient increase in reactive oxygen species during early development, exhibits increased stress resistance, improved redox homeostasis and prolonged lifespan, which are linked to a global decrease in level of the histone mark H3K4me3.
