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Nucleation experiments with water droplets containing differently sized graphene oxide nanosheets provide an experimental indication of the temperature-dependent size of the critical ice nucleus.
During foraging for live prey, zebrafish larvae alternate between persistent exploitation and exploration behavioural states that correlate with distinct patterns of neuronal activation.
In patients with ulcerative colitis, chronic inflammation can lead to remodelling of the colorectal epithelium through positive selection of clones with mutations in genes related to IL-17 signalling, which, however, might be negatively selected during colitis-associated carcinogenesis.
Whole-exome sequencing of colon organoids derived from patients with ulcerative colitis identifies somatic mutations in components of the IL-17 signalling pathway, which may confer a growth advantage to cells under inflammatory conditions.
Bayesian modelling of radiometric age estimates provides a robust chronology for Homo erectus at Ngandong (Java), confirming that this site currently represents the last known occurrence of this species.
Study of droplets containing nematic liquid crystal oligomers shows that a heterogeneous distribution of chain lengths plays a key part in driving reversible shape transformations with cooling and heating.
A 3D culture system to model human embryonic development, together with single-cell transcriptome profiling, provides insights into the molecular developmental landscape during human post-implantation embryogenesis.
Pd-catalysed β-C(sp3)–H lactonization of aliphatic acids enabled by a mono-N-protected β-amino acid and tert-butyl hydrogen peroxide is reported, achieving high β-position selectivity without the use of a directing group.
Data mining of a computational library of metal–organic frameworks identifies motifs that bind CO2 sufficiently strongly and whose uptake is not affected by water, with application for the capture of CO2 from flue gases.
The MYST acetyltransferase HBO1 is a critical regulator in maintaining leukaemia stem cells, and a small-molecule inhibitor of HBO1 is developed that shows efficacy against a range of acute myeloid leukaemia cells.
A rock art panel from Sulawesi—dated to at least 43.9 thousand years ago—represents the oldest currently known figurative art in the world, and provides evidence of early storytelling through narrative hunting scenes.
The authors examine the immune cell infiltrates of human tumours and provide evidence for a population of CD8 T cells with stem-cell characteristics and proliferative capacity that reside in an antigen-presenting niche within tumours.
A dominantly inherited human autoinflammatory disease caused by mutations in RIPK1 is identified, and RIPK1 mutations that prevent caspase-8 cleavage sensitize cells to apoptosis, necroptosis and inflammation.
CRISPR–Cas9 mutagenesis screenings reveal that targeting REGNASE-1 leads to improved therapeutic efficacy of CD8+ T cells against mouse models of cancer, and identify BATF as a key target of REGNASE-1.
Conventionally, heat transfer occurs by conduction, convection or radiation, but has also been theoretically predicted to occur through quantum fluctuations across a vacuum; this prediction has now been confirmed experimentally.
Single-cell mapping of chromatin accessibility, DNA methylation and RNA expression during gastrulation in mouse embryos shows characteristic epigenetic changes that accompany formation of the primary germ layers.
KRAS4A interacts directly with hexokinase 1 in a GTP-dependent manner at the outer mitochondrial membrane, leading to kinase activation and an increase in glucose uptake and glycolysis in tumour cells.
A whole-genome short interfering RNA screen identified vacuolar ATPase as a regulator of macropinocytosis induced by oncogenic RAS, a key determinant of tumour cell growth under nutrient-limiting conditions.