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Wild Australian magpies (Cracticus tibicen dorsalis) living in large groups show increased cognitive performance, which is associated with increased reproductive success.
A crystal structure of DNMT3A and its regulatory partner DNMT3L bound to DNA reveals the mechanistic basis for DNMT3A-mediated DNA methylation and establishes its aetiological link to human disease.
The transcription factor c-MAF is required for the generation of Helicobacter-specific regulatory T cells that selectively restrain pro-inflammatory TH17 cells; the absence of c-MAF in mouse regulatory T cells results in pathobiont-dependent inflammatory bowel disease.
A method for modelling time-varying dynamic stability in a natural marine fish community finds that seasonal patterns in community stability are driven by species diversity and interspecific interactions.
A working memory task in rats demonstrates that the posterior parietal cortex is a critical locus for the representation and use of prior stimulus information.
Stem cells of the Drosophila midgut sense mechanical signals in vivo through the stretch-activated ion channel Piezo, which is expressed on previously unidentified enteroendocrine precursor cells.
The transmembrane protein teneurin-3 is expressed in multiple topographically interconnected areas of the hippocampal region and acts in both projection and target neurons to control wiring specificity from CA1 to the subiculum.
In a mouse model of breast cancer, asparagine bioavailability strongly influences metastasis and this is correlated with the production of proteins that regulate the epithelial-to-mesenchymal transition, which provides at least one potential mechanism for how a single amino acid could regulate metastatic progression.
Temperature variability decreased globally by a factor of four between the Last Glacial Maximum and the Holocene epoch, as a result of changes in the meridional temperature gradient.
An Antarctic ice core reveals that, during the last ice age, the topography of Northern Hemisphere ice sheets shifted tropical Pacific convection eastward, increasing climate variability in the high southern latitudes.
Lithic assemblages from the archaeological site of Attirampakkam, India, document processes of transition from Acheulian to Middle Palaeolithic cultures and substantial behavioural changes around 385,000 years ago and thereafter.
A photocatalytic strategy is described that generates diazomethyl radicals as direct equivalents of carbynes, which are often too reactive to use, enabling the functionalization of a range of medically useful compounds.
The halo of gas around a galaxy at redshift 1 is clumpy and anisotropic, with little variation in gas velocity, suggesting that it consists of entrained recycled material.
In a basket trial design, the efficacy of the pan-HER kinase inhibitor neratinib is tested in patients with 21 different tumour types, and responses are determined by mutation and tissue type, and are restricted to HER2-mutant cancers.
Analysis at high temporal and spatial resolution shows that the number and dynamics of SNARE proteins available during exocytosis determines the size and stability of fusion pores.
A dated phylogeny and spatial distribution data for Chinese angiosperms show that eastern China has tended to act as a refugium for older taxa whereas western China has acted as a centre for their evolutionary diversification.
A kinetic model is proposed to predict the probability of dG•dT misincorporation across different polymerases, and provides mechanisms for sequence-dependent misincorporation.
Measurement of human plasma amyloid-β biomarkers using immunoprecipitation coupled with mass spectrometry reliably predicts individual brain amyloid-β status and has potential clinical utility.