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A numerical model shows that the net effect of the winds driven by the polar energy inputs is not to heat, but to cool the low-latitude thermosphere. This surprising result allows us to rule out known polar energy inputs as the solution to the energy crisis at Saturn.
One of two papers showing that reactivation of the endogenous p53 tumour suppressor genes in established tumours causes cancer regression. In some tumours, p53 reactivation causes cellular senescence associated with an innate immune response that contributes to tumour clearance.
One of two papers showing that reactivation of the endogenous p53 tumour suppressor genes in established tumours causes cancer regression. In some tumours, p53 reactivation causes cellular senescence associated with an innate immune response that contributes to tumour clearance.
The structure of TPP1's oligonucleotide binding fold contains features that are particularly characteristic of TEBPβ. When the POT1–TPP1 complex is bound to telomeric DNA, it does not inhibit telomerase activity, as other telomere binding proteins do. Instead, the presence of POT1–TPP1 unexpectedly stimulates telomerase activity and processivity.
The DHFR major promoter is repressed in quiescent cells by a non-coding RNA initiated from an upstream promoter. This RNA molecule forms a complex with the major promoter, interacts with the general transcription factor IIB, and dissociates the pre-initiation complex from the promoter.
The structure of TPP1's oligonucleotide binding fold contains features that are particularly characteristic of TEBPβ. When the POT1–TPP1 complex is bound to telomeric DNA, it does not inhibit telomerase activity, as other telomere binding proteins do. Instead, the presence of POT1–TPP1 unexpectedly stimulates telomerase activity and processivity.
By overcoming the molecular weight limitations that have traditionally hampered quantitative nuclear magnetic resonance spectroscopy (NMR) studies, the dynamics of the 670-kilodalton 20S proteasome core particle have been explored. A selective isotope labelling scheme along with experiments that preserve the lifetimes of the resulting NMR signals reveal functionally important motions and interactions by recording spectra on complexes with molecular weights up to 1 MDa.
The discovery of sH hydrate in a sample from Barkley Canyon marks the first time this hydrate has been found in the natural environment. This complex gas hydrate can trap larger guest molecules than sI or sII hydrate, and is stable at higher temperatures and pressures than sI hydrate, indicating that gas hydrates could be more widely distributed than previously thought.
A new class of hybrid metal-organic materials that exhibit magnetic ordering well above room temperature is presented. Although a precise structural model for these materials has yet to be elucidated, the versatility of their solution-based synthesis route suggests that it should be possible to prepare a wide range of analogous magnets.