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Materials are described here that can change their crystalline phase in response to the electrically controlled insertion or extraction of oxygen and hydrogen ions, giving rise to three distinct phases with different optical, electrical and magnetic properties.
The establishment of a drug-discovery screening pipeline for cryptosporidiosis, and identification of pyrazolopyridines as selective ATP-competitive inhibitors of the Cryptosporidium lipid kinase PI(4)K.
The structure of human ABCG2 bound to an inhibitory antibody using cryo-electron microscopy, representing the first high-resolution structural data of a human multidrug transporter.
Four galaxies discovered near quasars at redshifts exceeding 6 have star-formation rates that are high enough to explain the massive elliptical galaxies known to exist at redshifts of about 4.
An antiferromagnet with a correlation length that encompasses the whole system is created with the aid of quantum gas microscopy of cold atoms in an optical lattice.
In human cell lines with mutant KRAS and loss of LKB1, CPS1 expression correlates inversely with LKB1 expression; silencing CPS1 in these cells induces DNA damage and cell death as a result of pyrimidine depletion rather than ammonia toxicity.
Virus genomes reveal the establishment of Zika virus in Brazil and the Americas, and provide an appropriate timeframe for baseline (pre-Zika) microcephaly in different regions.
Using confocal and lattice light sheet microscopy, the authors perform systems-level analysis of the organelle interactome in live cells, allowing them to visualize the frequency and locality of up to five-way interactions between different organelles.
The chemoattractant S1P is identified as an extrinsic factor that supports naive T cell survival, and acts via a signalling mechanism to maintain mitochondrial content and function.
Structural ensembles of the 70S ribosome bound to cognate or near-cognate charged tRNAs in complex with EF-Tu illustrate the crucial role of the nucleotide G530 in decoding of mRNA, and demonstrate that translational fidelity results from direct control of GTPase by the decoding centre.
Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Caribbean is the most likely source.
A tree biodiversity and ecosystem function experiment shows that leaf bacterial diversity is positively related to plant community productivity, and explains a portion of the variation in productivity that would otherwise be attributed to plant diversity and functional traits.
One hundred and ten Zika virus genomes from ten countries and territories involved in the Zika virus epidemic reveal rapid expansion of the epidemic within Brazil and multiple introductions to other regions.
A high-quality reference for the sunflower genome (Helianthus annuus L.) and analysis of gene networks involved in flowering time and oil metabolism provide a basis for nutritional exploitation and analyses of adaptation to climate change.
The cryo-electron microscopy structure of the yeast spliceosome in a pre-catalytic state provides insights into the molecular events leading to formation of the spliceosome active site.
McCluskey returned in 1997 as chair of microbiology and immunology at the University of Melbourne, and became deputy vice-chancellor (research) in 2011.