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    The first global meeting to cover the complete range of issues concerning contemporary science and its relationship to society for almost 20 years, took place in Budapest from 26 06 to 1 07 1999, jointly organized by the United Nations Educational, Scientific and Cultural Organization (Unesco) and the International Council for Science (ICSU).

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    The 40th anniversary of the Kitt Peak National Observatory seems an appropriate time to reflect on how far we have come, and where the future of astronomy might lie.

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    This supplement offers a series of Review Articles from Natureaddressing advances in drug delivery, xenotransplantation and cell and gene therapy.

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    This NatureGuide to Scientific Opportunities in Spain (April 1998) demonstrates the enthusiasm of the country's institutions — from autonomous regional governments to universities, research institutes and industry — for extending the boundaries of the national scientific endeavour.

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    Selected papers from 1997 issues of Nature.

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    A selection of Review Articles and Letters from Naturereporting advances in nanoscience and nanotechnology during 1996—7.

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    Developments in techniques of pharmaceutical chemistry have revolutionized the design of drugs beyond previous expectations. But what are our current expectations and what does the future hold? Glaxo Wellcome has set itself the objective of introducing three significant new medicines a year, every year, by 2000.

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    Developments in techniques of pharmaceutical chemistry have revolutionized the design of drugs beyond previous expectations. But what are our current expectations and what does the future hold? Glaxo Wellcome has set itself the objective of introducing three significant new medicines a year, every year, by 2000.

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    An extended reprint of the manuscript A comprehensive genetic map of the human genome based on 5,264 microsatellitespublished inNatureon 14 03 1996.