Articles

  • Article |

    • Haley J. Abel
    • , David E. Larson
    • , Allison A. Regier
    • , Colby Chiang
    • , Indraniel Das
    • , Krishna L. Kanchi
    • , Ryan M. Layer
    • , Benjamin M. Neale
    • , William J. Salerno
    • , Catherine Reeves
    • , Steven Buyske
    • , Goncalo R. Abecasis
    • , Elizabeth Appelbaum
    • , Julie Baker
    • , Eric Banks
    • , Raphael A. Bernier
    • , Toby Bloom
    • , Michael Boehnke
    • , Eric Boerwinkle
    • , Erwin P. Bottinger
    • , Steven R. Brant
    • , Esteban G. Burchard
    • , Carlos D. Bustamante
    • , Lei Chen
    • , Judy H. Cho
    • , Rajiv Chowdhury
    • , Ryan Christ
    • , Lisa Cook
    • , Matthew Cordes
    • , Laura Courtney
    • , Michael J. Cutler
    • , Mark J. Daly
    • , Scott M. Damrauer
    • , Robert B. Darnell
    • , Tracie Deluca
    • , Huyen Dinh
    • , Harsha Doddapaneni
    • , Evan E. Eichler
    • , Patrick T. Ellinor
    • , Andres M. Estrada
    • , Yossi Farjoun
    • , Adam Felsenfeld
    • , Tatiana Foroud
    • , Nelson B. Freimer
    • , Catrina Fronick
    • , Lucinda Fulton
    • , Robert Fulton
    • , Stacy Gabriel
    • , Liron Ganel
    • , Shailu Gargeya
    • , Goren Germer
    • , Daniel H. Geschwind
    • , Richard A. Gibbs
    • , David B. Goldstein
    • , Megan L. Grove
    • , Namrata Gupta
    • , Christopher A. Haiman
    • , Yi Han
    • , Daniel Howrigan
    • , Jianhong Hu
    • , Carolyn Hutter
    • , Ivan Iossifov
    • , Bo Ji
    • , Lynn B. Jorde
    • , Goo Jun
    • , John Kane
    • , Chul Joo Kang
    • , Hyun Min Kang
    • , Sek Kathiresan
    • , Eimear E. Kenny
    • , Lily Khaira
    • , Ziad Khan
    • , Amit Khera
    • , Charles Kooperberg
    • , Olga Krasheninina
    • , William E. Kraus
    • , Subra Kugathasan
    • , Markku Laakso
    • , Tuuli Lappalainen
    • , Adam E. Locke
    • , Ruth J. F. Loos
    • , Amy Ly
    • , Robert Maier
    • , Tom Maniatis
    • , Loic Le Marchand
    • , Gregory M. Marcus
    • , Richard P. Mayeux
    • , Dermot P. B. McGovern
    • , Karla S. Mendoza
    • , Vipin Menon
    • , Ginger A. Metcalf
    • , Zeineen Momin
    • , Guiseppe Narzisi
    • , Joanne Nelson
    • , Caitlin Nessner
    • , Rodney D. Newberry
    • , Kari E. North
    • , Aarno Palotie
    • , Ulrike Peters
    • , Jennifer Ponce
    • , Clive Pullinger
    • , Aaron Quinlan
    • , Daniel J. Rader
    • , Stephen S. Rich
    • , Samuli Ripatti
    • , Dan M. Roden
    • , Veikko Salomaa
    • , Jireh Santibanez
    • , Svati H. Shah
    • , M. Benjamin Shoemaker
    • , Heidi Sofia
    • , Taylorlyn Stephan
    • , Christine Stevens
    • , Stephan R. Targan
    • , Marja-Riitta Taskinen
    • , Kathleen Tibbetts
    • , Charlotte Tolonen
    • , Tychele Turner
    • , Paul De Vries
    • , Jason Waligorski
    • , Kimberly Walker
    • , Vivian Ota Wang
    • , Michael Wigler
    • , Richard K. Wilson
    • , Lara Winterkorn
    • , Genevieve Wojcik
    • , Jinchuan Xing
    • , Erica Young
    • , Bing Yu
    • , Yeting Zhang
    • , Tara C. Matise
    • , Donna M. Muzny
    • , Michael C. Zody
    • , Eric S. Lander
    • , Susan K. Dutcher
    • , Nathan O. Stitziel
    •  & Ira M. Hall
  • Article |

    The authors identify an increased hepatic NADH/NAD+ ratio as an underlying metabolic parameter that is shaped by human genetic variation and contributes causally to key metabolic traits and diseases.

    • Russell P. Goodman
    • , Andrew L. Markhard
    • , Hardik Shah
    • , Rohit Sharma
    • , Owen S. Skinner
    • , Clary B. Clish
    • , Amy Deik
    • , Anupam Patgiri
    • , Yu-Han H. Hsu
    • , Ricard Masia
    • , Hye Lim Noh
    • , Sujin Suk
    • , Olga Goldberger
    • , Joel N. Hirschhorn
    • , Gary Yellen
    • , Jason K. Kim
    •  & Vamsi K. Mootha
  • Article |

    Repression of a messenger RNA by a cognate microRNA depends not only on complementary base pairing, but also on the rearrangement of a single base pair, producing a conformation that fits better within the human Ago2 protein.

    • Lorenzo Baronti
    • , Ileana Guzzetti
    • , Parisa Ebrahimi
    • , Sarah Friebe Sandoz
    • , Emilie Steiner
    • , Judith Schlagnitweit
    • , Bastian Fromm
    • , Luis Silva
    • , Carolina Fontana
    • , Alan A. Chen
    •  & Katja Petzold
  • Article |

    Composite mutations, of two or more nonsynonymous somatic mutations in the same cancer-associated gene, are present in nearly one in four human tumours.

    • Alexander N. Gorelick
    • , Francisco J. Sánchez-Rivera
    • , Yanyan Cai
    • , Craig M. Bielski
    • , Evan Biederstedt
    • , Philip Jonsson
    • , Allison L. Richards
    • , Neil Vasan
    • , Alexander V. Penson
    • , Noah D. Friedman
    • , Yu-Jui Ho
    • , Timour Baslan
    • , Chaitanya Bandlamudi
    • , Maurizio Scaltriti
    • , Nikolaus Schultz
    • , Scott W. Lowe
    • , Ed Reznik
    •  & Barry S. Taylor
  • Article |

    Large-area single-crystal high-index copper and nickel foils with several types of facet are fabricated using mild pre-oxidation of the metal foil surface followed by annealing in a reducing atmosphere.

    • Muhong Wu
    • , Zhibin Zhang
    • , Xiaozhi Xu
    • , Zhihong Zhang
    • , Yunrui Duan
    • , Jichen Dong
    • , Ruixi Qiao
    • , Sifan You
    • , Li Wang
    • , Jiajie Qi
    • , Dingxin Zou
    • , Nianze Shang
    • , Yubo Yang
    • , Hui Li
    • , Lan Zhu
    • , Junliang Sun
    • , Haijun Yu
    • , Peng Gao
    • , Xuedong Bai
    • , Ying Jiang
    • , Zhu-Jun Wang
    • , Feng Ding
    • , Dapeng Yu
    • , Enge Wang
    •  & Kaihui Liu
  • Article |

    The baryon density determined along the lines of sight to localized fast radio bursts is consistent with that determined from the cosmic microwave background and required by Big Bang nucleosynthesis.

    • J.-P. Macquart
    • , J. X. Prochaska
    • , M. McQuinn
    • , K. W. Bannister
    • , S. Bhandari
    • , C. K. Day
    • , A. T. Deller
    • , R. D. Ekers
    • , C. W. James
    • , L. Marnoch
    • , S. Osłowski
    • , C. Phillips
    • , S. D. Ryder
    • , D. R. Scott
    • , R. M. Shannon
    •  & N. Tejos
  • Article |

    A thermo-assisted spin-coating process followed by packaging is used to fabricate sodium films that are stable for several months, enabling the realization of plasmonic devices with state-of-the-art performance at near-infrared wavelengths.

    • Yang Wang
    • , Jianyu Yu
    • , Yi-Fei Mao
    • , Ji Chen
    • , Suo Wang
    • , Hua-Zhou Chen
    • , Yi Zhang
    • , Si-Yi Wang
    • , Xinjie Chen
    • , Tao Li
    • , Lin Zhou
    • , Ren-Min Ma
    • , Shining Zhu
    • , Wenshan Cai
    •  & Jia Zhu
  • Article |

    Measurements of low-energy electronic states of radium monofluoride validate predictions of the use of this short-lived radioactive molecule in exploring fundamental physics and provide evidence of its suitability for laser cooling.

    • R. F. Garcia Ruiz
    • , R. Berger
    • , J. Billowes
    • , C. L. Binnersley
    • , M. L. Bissell
    • , A. A. Breier
    • , A. J. Brinson
    • , K. Chrysalidis
    • , T. E. Cocolios
    • , B. S. Cooper
    • , K. T. Flanagan
    • , T. F. Giesen
    • , R. P. de Groote
    • , S. Franchoo
    • , F. P. Gustafsson
    • , T. A. Isaev
    • , Á. Koszorús
    • , G. Neyens
    • , H. A. Perrett
    • , C. M. Ricketts
    • , S. Rothe
    • , L. Schweikhard
    • , A. R. Vernon
    • , K. D. A. Wendt
    • , F. Wienholtz
    • , S. G. Wilkins
    •  & X. F. Yang
  • Article |

    A large empirical assessment of sequence-resolved structural variants from 14,891 genomes across diverse global populations in the Genome Aggregation Database (gnomAD) provides a reference map for disease-association studies, population genetics, and diagnostic screening.

    • Ryan L. Collins
    • , Harrison Brand
    • , Konrad J. Karczewski
    • , Xuefang Zhao
    • , Jessica Alföldi
    • , Laurent C. Francioli
    • , Amit V. Khera
    • , Chelsea Lowther
    • , Laura D. Gauthier
    • , Harold Wang
    • , Nicholas A. Watts
    • , Matthew Solomonson
    • , Anne O’Donnell-Luria
    • , Alexander Baumann
    • , Ruchi Munshi
    • , Mark Walker
    • , Christopher W. Whelan
    • , Yongqing Huang
    • , Ted Brookings
    • , Ted Sharpe
    • , Matthew R. Stone
    • , Elise Valkanas
    • , Jack Fu
    • , Grace Tiao
    • , Kristen M. Laricchia
    • , Valentin Ruano-Rubio
    • , Christine Stevens
    • , Namrata Gupta
    • , Caroline Cusick
    • , Lauren Margolin
    • , Jessica Alföldi
    • , Irina M. Armean
    • , Eric Banks
    • , Louis Bergelson
    • , Kristian Cibulskis
    • , Ryan L. Collins
    • , Kristen M. Connolly
    • , Miguel Covarrubias
    • , Beryl Cummings
    • , Mark J. Daly
    • , Stacey Donnelly
    • , Yossi Farjoun
    • , Steven Ferriera
    • , Laurent Francioli
    • , Stacey Gabriel
    • , Laura D. Gauthier
    • , Jeff Gentry
    • , Namrata Gupta
    • , Thibault Jeandet
    • , Diane Kaplan
    • , Konrad J. Karczewski
    • , Kristen M. Laricchia
    • , Christopher Llanwarne
    • , Eric V. Minikel
    • , Ruchi Munshi
    • , Benjamin M. Neale
    • , Sam Novod
    • , Anne H. O’Donnell-Luria
    • , Nikelle Petrillo
    • , Timothy Poterba
    • , David Roazen
    • , Valentin Ruano-Rubio
    • , Andrea Saltzman
    • , Kaitlin E. Samocha
    • , Molly Schleicher
    • , Cotton Seed
    • , Matthew Solomonson
    • , Jose Soto
    • , Grace Tiao
    • , Kathleen Tibbetts
    • , Charlotte Tolonen
    • , Christopher Vittal
    • , Gordon Wade
    • , Arcturus Wang
    • , Qingbo Wang
    • , James S. Ware
    • , Nicholas A. Watts
    • , Ben Weisburd
    • , Nicola Whiffin
    • , Carlos A. Aguilar Salinas
    • , Tariq Ahmad
    • , Christine M. Albert
    • , Diego Ardissino
    • , Gil Atzmon
    • , John Barnard
    • , Laurent Beaugerie
    • , Emelia J. Benjamin
    • , Michael Boehnke
    • , Lori L. Bonnycastle
    • , Erwin P. Bottinger
    • , Donald W. Bowden
    • , Matthew J. Bown
    • , John C. Chambers
    • , Juliana C. Chan
    • , Daniel Chasman
    • , Judy Cho
    • , Mina K. Chung
    • , Bruce Cohen
    • , Adolfo Correa
    • , Dana Dabelea
    • , Mark J. Daly
    • , Dawood Darbar
    • , Ravindranath Duggirala
    • , Josée Dupuis
    • , Patrick T. Ellinor
    • , Roberto Elosua
    • , Jeanette Erdmann
    • , Tõnu Esko
    • , Martti Färkkilä
    • , Jose Florez
    • , Andre Franke
    • , Gad Getz
    • , Benjamin Glaser
    • , Stephen J. Glatt
    • , David Goldstein
    • , Clicerio Gonzalez
    • , Leif Groop
    • , Christopher Haiman
    • , Craig Hanis
    • , Matthew Harms
    • , Mikko Hiltunen
    • , Matti M. Holi
    • , Christina M. Hultman
    • , Mikko Kallela
    • , Jaakko Kaprio
    • , Sekar Kathiresan
    • , Bong-Jo Kim
    • , Young Jin Kim
    • , George Kirov
    • , Jaspal Kooner
    • , Seppo Koskinen
    • , Harlan M. Krumholz
    • , Subra Kugathasan
    • , Soo Heon Kwak
    • , Markku Laakso
    • , Terho Lehtimäki
    • , Ruth J. F. Loos
    • , Steven A. Lubitz
    • , Ronald C. W. Ma
    • , Daniel G. MacArthur
    • , Jaume Marrugat
    • , Kari M. Mattila
    • , Steven McCarroll
    • , Mark I. McCarthy
    • , Dermot McGovern
    • , Ruth McPherson
    • , James B. Meigs
    • , Olle Melander
    • , Andres Metspalu
    • , Benjamin M. Neale
    • , Peter M. Nilsson
    • , Michael C. O’Donovan
    • , Dost Ongur
    • , Lorena Orozco
    • , Michael J. Owen
    • , Colin N. A. Palmer
    • , Aarno Palotie
    • , Kyong Soo Park
    • , Carlos Pato
    • , Ann E. Pulver
    • , Nazneen Rahman
    • , Anne M. Remes
    • , John D. Rioux
    • , Samuli Ripatti
    • , Dan M. Roden
    • , Danish Saleheen
    • , Veikko Salomaa
    • , Nilesh J. Samani
    • , Jeremiah Scharf
    • , Heribert Schunkert
    • , Moore B. Shoemaker
    • , Pamela Sklar
    • , Hilkka Soininen
    • , Harry Sokol
    • , Tim Spector
    • , Patrick F. Sullivan
    • , Jaana Suvisaari
    • , E. Shyong Tai
    • , Yik Ying Teo
    • , Tuomi Tiinamaija
    • , Ming Tsuang
    • , Dan Turner
    • , Teresa Tusie-Luna
    • , Erkki Vartiainen
    • , James S. Ware
    • , Hugh Watkins
    • , Rinse K. Weersma
    • , Maija Wessman
    • , James G. Wilson
    • , Ramnik J. Xavier
    • , Kent D. Taylor
    • , Henry J. Lin
    • , Stephen S. Rich
    • , Wendy S. Post
    • , Yii-Der Ida Chen
    • , Jerome I. Rotter
    • , Chad Nusbaum
    • , Anthony Philippakis
    • , Eric Lander
    • , Stacey Gabriel
    • , Benjamin M. Neale
    • , Sekar Kathiresan
    • , Mark J. Daly
    • , Eric Banks
    • , Daniel G. MacArthur
    •  & Michael E. Talkowski
  • Article |

    Cryo-electron microscopy studies of the influenza haemagglutinin glycoprotein at the low pH of host endosomes reveals structural intermediates, offering a dynamic view of how the protein mediates membrane fusion.

    • Donald J. Benton
    • , Steven J. Gamblin
    • , Peter B. Rosenthal
    •  & John J. Skehel
  • Article |

    A novel variant annotation metric that quantifies the level of expression of genetic variants across tissues is validated in the Genome Aggregation Database (gnomAD) and is shown to improve rare variant interpretation.

    • Beryl B. Cummings
    • , Konrad J. Karczewski
    • , Jack A. Kosmicki
    • , Eleanor G. Seaby
    • , Nicholas A. Watts
    • , Moriel Singer-Berk
    • , Jonathan M. Mudge
    • , Juha Karjalainen
    • , F. Kyle Satterstrom
    • , Anne H. O’Donnell-Luria
    • , Timothy Poterba
    • , Cotton Seed
    • , Matthew Solomonson
    • , Jessica Alföldi
    • , Jessica Alföldi
    • , Irina M. Armean
    • , Eric Banks
    • , Louis Bergelson
    • , Kristian Cibulskis
    • , Ryan L. Collins
    • , Kristen M. Connolly
    • , Miguel Covarrubias
    • , Beryl B. Cummings
    • , Mark J. Daly
    • , Stacey Donnelly
    • , Yossi Farjoun
    • , Steven Ferriera
    • , Laurent Francioli
    • , Stacey Gabriel
    • , Laura D. Gauthier
    • , Jeff Gentry
    • , Namrata Gupta
    • , Thibault Jeandet
    • , Diane Kaplan
    • , Konrad J. Karczewski
    • , Kristen M. Laricchia
    • , Christopher Llanwarne
    • , Eric V. Minikel
    • , Ruchi Munshi
    • , Benjamin M. Neale
    • , Sam Novod
    • , Anne H. O’Donnell-Luria
    • , Nikelle Petrillo
    • , Timothy Poterba
    • , David Roazen
    • , Valentin Ruano-Rubio
    • , Andrea Saltzman
    • , Kaitlin E. Samocha
    • , Molly Schleicher
    • , Cotton Seed
    • , Matthew Solomonson
    • , Jose Soto
    • , Grace Tiao
    • , Kathleen Tibbetts
    • , Charlotte Tolonen
    • , Christopher Vittal
    • , Gordon Wade
    • , Arcturus Wang
    • , Qingbo Wang
    • , James S. Ware
    • , Nicholas A. Watts
    • , Ben Weisburd
    • , Nicola Whiffin
    • , Carlos A. Aguilar Salinas
    • , Tariq Ahmad
    • , Christine M. Albert
    • , Diego Ardissino
    • , Gil Atzmon
    • , John Barnard
    • , Laurent Beaugerie
    • , Emelia J. Benjamin
    • , Michael Boehnke
    • , Lori L. Bonnycastle
    • , Erwin P. Bottinger
    • , Donald W. Bowden
    • , Matthew J. Bown
    • , John C. Chambers
    • , Juliana C. Chan
    • , Daniel Chasman
    • , Judy Cho
    • , Mina K. Chung
    • , Bruce Cohen
    • , Adolfo Correa
    • , Dana Dabelea
    • , Mark J. Daly
    • , Dawood Darbar
    • , Ravindranath Duggirala
    • , Josée Dupuis
    • , Patrick T. Ellinor
    • , Roberto Elosua
    • , Jeanette Erdmann
    • , Tõnu Esko
    • , Martti Färkkilä
    • , Jose Florez
    • , Andre Franke
    • , Gad Getz
    • , Benjamin Glaser
    • , Stephen J. Glatt
    • , David Goldstein
    • , Clicerio Gonzalez
    • , Leif Groop
    • , Christopher Haiman
    • , Craig Hanis
    • , Matthew Harms
    • , Mikko Hiltunen
    • , Matti M. Holi
    • , Christina M. Hultman
    • , Mikko Kallela
    • , Jaakko Kaprio
    • , Sekar Kathiresan
    • , Bong-Jo Kim
    • , Young Jin Kim
    • , George Kirov
    • , Jaspal Kooner
    • , Seppo Koskinen
    • , Harlan M. Krumholz
    • , Subra Kugathasan
    • , Soo Heon Kwak
    • , Markku Laakso
    • , Terho Lehtimäki
    • , Ruth J. F. Loos
    • , Steven A. Lubitz
    • , Ronald C. W. Ma
    • , Daniel G. MacArthur
    • , Jaume Marrugat
    • , Kari M. Mattila
    • , Steven McCarroll
    • , Mark I. McCarthy
    • , Dermot McGovern
    • , Ruth McPherson
    • , James B. Meigs
    • , Olle Melander
    • , Andres Metspalu
    • , Benjamin M. Neale
    • , Peter M. Nilsson
    • , Michael C. O’Donovan
    • , Dost Ongur
    • , Lorena Orozco
    • , Michael J. Owen
    • , Colin N. A. Palmer
    • , Aarno Palotie
    • , Kyong Soo Park
    • , Carlos Pato
    • , Ann E. Pulver
    • , Nazneen Rahman
    • , Anne M. Remes
    • , John D. Rioux
    • , Samuli Ripatti
    • , Dan M. Roden
    • , Danish Saleheen
    • , Veikko Salomaa
    • , Nilesh J. Samani
    • , Jeremiah Scharf
    • , Heribert Schunkert
    • , Moore B. Shoemaker
    • , Pamela Sklar
    • , Hilkka Soininen
    • , Harry Sokol
    • , Tim Spector
    • , Patrick F. Sullivan
    • , Jaana Suvisaari
    • , E. Shyong Tai
    • , Yik Ying Teo
    • , Tuomi Tiinamaija
    • , Ming Tsuang
    • , Dan Turner
    • , Teresa Tusie-Luna
    • , Erkki Vartiainen
    • , James S. Ware
    • , Hugh Watkins
    • , Rinse K. Weersma
    • , Maija Wessman
    • , James G. Wilson
    • , Ramnik J. Xavier
    • , Mark J. Daly
    •  & Daniel G. MacArthur
  • Article |

    Water splitting with an internal quantum efficiency of almost unity is achieved using a modified semiconductor photocatalyst that selectively promotes the hydrogen and oxygen evolution reactions on separate crystal facets.

    • Tsuyoshi Takata
    • , Junzhe Jiang
    • , Yoshihisa Sakata
    • , Mamiko Nakabayashi
    • , Naoya Shibata
    • , Vikas Nandal
    • , Kazuhiko Seki
    • , Takashi Hisatomi
    •  & Kazunari Domen
  • Article |

    Cryo-electron microscopy reveals the structures of α-synuclein filaments from the brains of individuals with multiple system atrophy.

    • Manuel Schweighauser
    • , Yang Shi
    • , Airi Tarutani
    • , Fuyuki Kametani
    • , Alexey G. Murzin
    • , Bernardino Ghetti
    • , Tomoyasu Matsubara
    • , Taisuke Tomita
    • , Takashi Ando
    • , Kazuko Hasegawa
    • , Shigeo Murayama
    • , Mari Yoshida
    • , Masato Hasegawa
    • , Sjors H. W. Scheres
    •  & Michel Goedert
  • Article |

    A catalogue of predicted loss-of-function variants in 125,748 whole-exome and 15,708 whole-genome sequencing datasets from the Genome Aggregation Database (gnomAD) reveals the spectrum of mutational constraints that affect these human protein-coding genes.

    • Konrad J. Karczewski
    • , Laurent C. Francioli
    • , Grace Tiao
    • , Beryl B. Cummings
    • , Jessica Alföldi
    • , Qingbo Wang
    • , Ryan L. Collins
    • , Kristen M. Laricchia
    • , Andrea Ganna
    • , Daniel P. Birnbaum
    • , Laura D. Gauthier
    • , Harrison Brand
    • , Matthew Solomonson
    • , Nicholas A. Watts
    • , Daniel Rhodes
    • , Moriel Singer-Berk
    • , Eleina M. England
    • , Eleanor G. Seaby
    • , Jack A. Kosmicki
    • , Raymond K. Walters
    • , Katherine Tashman
    • , Yossi Farjoun
    • , Eric Banks
    • , Timothy Poterba
    • , Arcturus Wang
    • , Cotton Seed
    • , Nicola Whiffin
    • , Jessica X. Chong
    • , Kaitlin E. Samocha
    • , Emma Pierce-Hoffman
    • , Zachary Zappala
    • , Anne H. O’Donnell-Luria
    • , Eric Vallabh Minikel
    • , Ben Weisburd
    • , Monkol Lek
    • , James S. Ware
    • , Christopher Vittal
    • , Irina M. Armean
    • , Louis Bergelson
    • , Kristian Cibulskis
    • , Kristen M. Connolly
    • , Miguel Covarrubias
    • , Stacey Donnelly
    • , Steven Ferriera
    • , Stacey Gabriel
    • , Jeff Gentry
    • , Namrata Gupta
    • , Thibault Jeandet
    • , Diane Kaplan
    • , Christopher Llanwarne
    • , Ruchi Munshi
    • , Sam Novod
    • , Nikelle Petrillo
    • , David Roazen
    • , Valentin Ruano-Rubio
    • , Andrea Saltzman
    • , Molly Schleicher
    • , Jose Soto
    • , Kathleen Tibbetts
    • , Charlotte Tolonen
    • , Gordon Wade
    • , Michael E. Talkowski
    • , Carlos A. Aguilar Salinas
    • , Tariq Ahmad
    • , Christine M. Albert
    • , Diego Ardissino
    • , Gil Atzmon
    • , John Barnard
    • , Laurent Beaugerie
    • , Emelia J. Benjamin
    • , Michael Boehnke
    • , Lori L. Bonnycastle
    • , Erwin P. Bottinger
    • , Donald W. Bowden
    • , Matthew J. Bown
    • , John C. Chambers
    • , Juliana C. Chan
    • , Daniel Chasman
    • , Judy Cho
    • , Mina K. Chung
    • , Bruce Cohen
    • , Adolfo Correa
    • , Dana Dabelea
    • , Mark J. Daly
    • , Dawood Darbar
    • , Ravindranath Duggirala
    • , Josée Dupuis
    • , Patrick T. Ellinor
    • , Roberto Elosua
    • , Jeanette Erdmann
    • , Tõnu Esko
    • , Martti Färkkilä
    • , Jose Florez
    • , Andre Franke
    • , Gad Getz
    • , Benjamin Glaser
    • , Stephen J. Glatt
    • , David Goldstein
    • , Clicerio Gonzalez
    • , Leif Groop
    • , Christopher Haiman
    • , Craig Hanis
    • , Matthew Harms
    • , Mikko Hiltunen
    • , Matti M. Holi
    • , Christina M. Hultman
    • , Mikko Kallela
    • , Jaakko Kaprio
    • , Sekar Kathiresan
    • , Bong-Jo Kim
    • , Young Jin Kim
    • , George Kirov
    • , Jaspal Kooner
    • , Seppo Koskinen
    • , Harlan M. Krumholz
    • , Subra Kugathasan
    • , Soo Heon Kwak
    • , Markku Laakso
    • , Terho Lehtimäki
    • , Ruth J. F. Loos
    • , Steven A. Lubitz
    • , Ronald C. W. Ma
    • , Daniel G. MacArthur
    • , Jaume Marrugat
    • , Kari M. Mattila
    • , Steven McCarroll
    • , Mark I. McCarthy
    • , Dermot McGovern
    • , Ruth McPherson
    • , James B. Meigs
    • , Olle Melander
    • , Andres Metspalu
    • , Benjamin M. Neale
    • , Peter M. Nilsson
    • , Michael C. O’Donovan
    • , Dost Ongur
    • , Lorena Orozco
    • , Michael J. Owen
    • , Colin N. A. Palmer
    • , Aarno Palotie
    • , Kyong Soo Park
    • , Carlos Pato
    • , Ann E. Pulver
    • , Nazneen Rahman
    • , Anne M. Remes
    • , John D. Rioux
    • , Samuli Ripatti
    • , Dan M. Roden
    • , Danish Saleheen
    • , Veikko Salomaa
    • , Nilesh J. Samani
    • , Jeremiah Scharf
    • , Heribert Schunkert
    • , Moore B. Shoemaker
    • , Pamela Sklar
    • , Hilkka Soininen
    • , Harry Sokol
    • , Tim Spector
    • , Patrick F. Sullivan
    • , Jaana Suvisaari
    • , E. Shyong Tai
    • , Yik Ying Teo
    • , Tuomi Tiinamaija
    • , Ming Tsuang
    • , Dan Turner
    • , Teresa Tusie-Luna
    • , Erkki Vartiainen
    • , James S. Ware
    • , Hugh Watkins
    • , Rinse K. Weersma
    • , Maija Wessman
    • , James G. Wilson
    • , Ramnik J. Xavier
    • , Benjamin M. Neale
    • , Mark J. Daly
    •  & Daniel G. MacArthur
  • Article |

    In mice, the pseudoautosomal region of the sex chromosomes undergoes a dynamic structural rearrangement to promote a high rate of DNA double-strand breaks and to ensure X–Y recombination.

    • Laurent Acquaviva
    • , Michiel Boekhout
    • , Mehmet E. Karasu
    • , Kevin Brick
    • , Florencia Pratto
    • , Tao Li
    • , Megan van Overbeek
    • , Liisa Kauppi
    • , R. Daniel Camerini-Otero
    • , Maria Jasin
    •  & Scott Keeney
  • Article |

    • Bin Ju
    • , Qi Zhang
    • , Jiwan Ge
    • , Ruoke Wang
    • , Jing Sun
    • , Xiangyang Ge
    • , Jiazhen Yu
    • , Sisi Shan
    • , Bing Zhou
    • , Shuo Song
    • , Xian Tang
    • , Jinfang Yu
    • , Jun Lan
    • , Jing Yuan
    • , Haiyan Wang
    • , Juanjuan Zhao
    • , Shuye Zhang
    • , Youchun Wang
    • , Xuanling Shi
    • , Lei Liu
    • , Jincun Zhao
    • , Xinquan Wang
    • , Zheng Zhang
    •  & Linqi Zhang
  • Article |

    • Rui Shi
    • , Chao Shan
    • , Xiaomin Duan
    • , Zhihai Chen
    • , Peipei Liu
    • , Jinwen Song
    • , Tao Song
    • , Xiaoshan Bi
    • , Chao Han
    • , Lianao Wu
    • , Ge Gao
    • , Xue Hu
    • , Yanan Zhang
    • , Zhou Tong
    • , Weijin Huang
    • , William Jun Liu
    • , Guizhen Wu
    • , Bo Zhang
    • , Lan Wang
    • , Jianxun Qi
    • , Hui Feng
    • , Fu-sheng Wang
    • , Qihui Wang
    • , George Fu Gao
    • , Zhiming Yuan
    •  & Jinghua Yan
  • Article |

    • Xiaonan Zhang
    • , Yun Tan
    • , Yun Ling
    • , Gang Lu
    • , Feng Liu
    • , Zhigang Yi
    • , Xiaofang Jia
    • , Min Wu
    • , Bisheng Shi
    • , Shuibao Xu
    • , Jun Chen
    • , Wei Wang
    • , Bing Chen
    • , Lu Jiang
    • , Shuting Yu
    • , Jing Lu
    • , Jinzeng Wang
    • , Mingzhu Xu
    • , Zhenghong Yuan
    • , Qin Zhang
    • , Xinxin Zhang
    • , Guoping Zhao
    • , Shengyue Wang
    • , Saijuan Chen
    •  & Hongzhou Lu
  • Article |

    A biomimetic electrochemical eye is presented that has a hemispherical retina made from a high-density array of perovskite nanowires that are sensitive to light, mimicking the photoreceptors of a biological retina.

    • Leilei Gu
    • , Swapnadeep Poddar
    • , Yuanjing Lin
    • , Zhenghao Long
    • , Daquan Zhang
    • , Qianpeng Zhang
    • , Lei Shu
    • , Xiao Qiu
    • , Matthew Kam
    • , Ali Javey
    •  & Zhiyong Fan
  • Article |

    Cyclohexene isotopologues and stereoisotopomers with varying degrees of deuteration are formed by binding a tungsten complex to benzene, which facilitates the selective incorporation of deuterium into any position on the ring.

    • Jacob A. Smith
    • , Katy B. Wilson
    • , Reilly E. Sonstrom
    • , Patrick J. Kelleher
    • , Kevin D. Welch
    • , Emmit K. Pert
    • , Karl S. Westendorff
    • , Diane A. Dickie
    • , Xiaoping Wang
    • , Brooks H. Pate
    •  & W. Dean Harman
  • Article |

    Quantum entanglement is realized between rotational levels of a molecular ion with energy differences spanning several orders of magnitude and long-lived internal states of a single atomic ion.

    • Yiheng Lin
    • , David R. Leibrandt
    • , Dietrich Leibfried
    •  & Chin-wen Chou
  • Article |

    Experimental analysis of reconstructed ancestral globins reveals that haemoglobin’s complex tetrameric structure and oxygen-binding functions evolved by simple genetic and biophysical mechanisms.

    • Arvind S. Pillai
    • , Shane A. Chandler
    • , Yang Liu
    • , Anthony V. Signore
    • , Carlos R. Cortez-Romero
    • , Justin L. P. Benesch
    • , Arthur Laganowsky
    • , Jay F. Storz
    • , Georg K. A. Hochberg
    •  & Joseph W. Thornton
  • Article |

    Cryo-electron microscopy reveals the structures of the mitochondrial calcium uniporter holocomplex in low- and high-calcium conditions, showing the gating mechanism that underlies uniporter activation in response to intracellular calcium signals.

    • Minrui Fan
    • , Jinru Zhang
    • , Chen-Wei Tsai
    • , Benjamin J. Orlando
    • , Madison Rodriguez
    • , Yan Xu
    • , Maofu Liao
    • , Ming-Feng Tsai
    •  & Liang Feng
  • Article |

    Single-cell RNA sequencing of haematopoietic cells from human embryos at different developmental stages sheds light on the development and specification of macrophages in different tissues.

    • Zhilei Bian
    • , Yandong Gong
    • , Tao Huang
    • , Christopher Z. W. Lee
    • , Lihong Bian
    • , Zhijie Bai
    • , Hui Shi
    • , Yang Zeng
    • , Chen Liu
    • , Jian He
    • , Jie Zhou
    • , Xianlong Li
    • , Zongcheng Li
    • , Yanli Ni
    • , Chunyu Ma
    • , Lei Cui
    • , Rui Zhang
    • , Jerry K. Y. Chan
    • , Lai Guan Ng
    • , Yu Lan
    • , Florent Ginhoux
    •  & Bing Liu
  • Article |

    In Caenorhabditis elegans, the ribonucleotidyltransferase RDE-3 adds alternating uridine and guanosine ribonucleotides to the 3′ termini of RNAs, a key step in RNA interference and thus epigenetic inheritance in the C. elegans germline.

    • Aditi Shukla
    • , Jenny Yan
    • , Daniel J. Pagano
    • , Anne E. Dodson
    • , Yuhan Fei
    • , Josh Gorham
    • , J. G. Seidman
    • , Marvin Wickens
    •  & Scott Kennedy
  • Article |

    Feedback projections onto neurons of the mouse primary visual cortex generate a second excitatory receptive field that is driven by stimuli outside of the classical feedforward receptive field, with responses mediated by higher visual areas.

    • Andreas J. Keller
    • , Morgane M. Roth
    •  & Massimo Scanziani
  • Article |

    Applying a bias correction to a state-of-the-art dataset covering non-alpine regions of the Northern Hemisphere and to three other datasets yields a more constrained quantification of snow mass in March from 1980 to 2018.

    • Jouni Pulliainen
    • , Kari Luojus
    • , Chris Derksen
    • , Lawrence Mudryk
    • , Juha Lemmetyinen
    • , Miia Salminen
    • , Jaakko Ikonen
    • , Matias Takala
    • , Juval Cohen
    • , Tuomo Smolander
    •  & Johannes Norberg
  • Article |

    Crystallographic ‘snapshots’ taken at intervals of femtoseconds to milliseconds after activation show how a light-activated sodium pump carries sodium ions across the cell membrane.

    • Petr Skopintsev
    • , David Ehrenberg
    • , Tobias Weinert
    • , Daniel James
    • , Rajiv K. Kar
    • , Philip J. M. Johnson
    • , Dmitry Ozerov
    • , Antonia Furrer
    • , Isabelle Martiel
    • , Florian Dworkowski
    • , Karol Nass
    • , Gregor Knopp
    • , Claudio Cirelli
    • , Christopher Arrell
    • , Dardan Gashi
    • , Sandra Mous
    • , Maximilian Wranik
    • , Thomas Gruhl
    • , Demet Kekilli
    • , Steffen Brünle
    • , Xavier Deupi
    • , Gebhard F. X. Schertler
    • , Roger M. Benoit
    • , Valerie Panneels
    • , Przemyslaw Nogly
    • , Igor Schapiro
    • , Christopher Milne
    • , Joachim Heberle
    •  & Jörg Standfuss
  • Article |

    The results obtained by seventy different teams analysing the same functional magnetic resonance imaging dataset show substantial variation, highlighting the influence of analytical choices and the importance of sharing workflows publicly and performing multiple analyses.

    • Rotem Botvinik-Nezer
    • , Felix Holzmeister
    • , Colin F. Camerer
    • , Anna Dreber
    • , Juergen Huber
    • , Magnus Johannesson
    • , Michael Kirchler
    • , Roni Iwanir
    • , Jeanette A. Mumford
    • , R. Alison Adcock
    • , Paolo Avesani
    • , Blazej M. Baczkowski
    • , Aahana Bajracharya
    • , Leah Bakst
    • , Sheryl Ball
    • , Marco Barilari
    • , Nadège Bault
    • , Derek Beaton
    • , Julia Beitner
    • , Roland G. Benoit
    • , Ruud M. W. J. Berkers
    • , Jamil P. Bhanji
    • , Bharat B. Biswal
    • , Sebastian Bobadilla-Suarez
    • , Tiago Bortolini
    • , Katherine L. Bottenhorn
    • , Alexander Bowring
    • , Senne Braem
    • , Hayley R. Brooks
    • , Emily G. Brudner
    • , Cristian B. Calderon
    • , Julia A. Camilleri
    • , Jaime J. Castrellon
    • , Luca Cecchetti
    • , Edna C. Cieslik
    • , Zachary J. Cole
    • , Olivier Collignon
    • , Robert W. Cox
    • , William A. Cunningham
    • , Stefan Czoschke
    • , Kamalaker Dadi
    • , Charles P. Davis
    • , Alberto De Luca
    • , Mauricio R. Delgado
    • , Lysia Demetriou
    • , Jeffrey B. Dennison
    • , Xin Di
    • , Erin W. Dickie
    • , Ekaterina Dobryakova
    • , Claire L. Donnat
    • , Juergen Dukart
    • , Niall W. Duncan
    • , Joke Durnez
    • , Amr Eed
    • , Simon B. Eickhoff
    • , Andrew Erhart
    • , Laura Fontanesi
    • , G. Matthew Fricke
    • , Shiguang Fu
    • , Adriana Galván
    • , Remi Gau
    • , Sarah Genon
    • , Tristan Glatard
    • , Enrico Glerean
    • , Jelle J. Goeman
    • , Sergej A. E. Golowin
    • , Carlos González-García
    • , Krzysztof J. Gorgolewski
    • , Cheryl L. Grady
    • , Mikella A. Green
    • , João F. Guassi Moreira
    • , Olivia Guest
    • , Shabnam Hakimi
    • , J. Paul Hamilton
    • , Roeland Hancock
    • , Giacomo Handjaras
    • , Bronson B. Harry
    • , Colin Hawco
    • , Peer Herholz
    • , Gabrielle Herman
    • , Stephan Heunis
    • , Felix Hoffstaedter
    • , Jeremy Hogeveen
    • , Susan Holmes
    • , Chuan-Peng Hu
    • , Scott A. Huettel
    • , Matthew E. Hughes
    • , Vittorio Iacovella
    • , Alexandru D. Iordan
    • , Peder M. Isager
    • , Ayse I. Isik
    • , Andrew Jahn
    • , Matthew R. Johnson
    • , Tom Johnstone
    • , Michael J. E. Joseph
    • , Anthony C. Juliano
    • , Joseph W. Kable
    • , Michalis Kassinopoulos
    • , Cemal Koba
    • , Xiang-Zhen Kong
    • , Timothy R. Koscik
    • , Nuri Erkut Kucukboyaci
    • , Brice A. Kuhl
    • , Sebastian Kupek
    • , Angela R. Laird
    • , Claus Lamm
    • , Robert Langner
    • , Nina Lauharatanahirun
    • , Hongmi Lee
    • , Sangil Lee
    • , Alexander Leemans
    • , Andrea Leo
    • , Elise Lesage
    • , Flora Li
    • , Monica Y. C. Li
    • , Phui Cheng Lim
    • , Evan N. Lintz
    • , Schuyler W. Liphardt
    • , Annabel B. Losecaat Vermeer
    • , Bradley C. Love
    • , Michael L. Mack
    • , Norberto Malpica
    • , Theo Marins
    • , Camille Maumet
    • , Kelsey McDonald
    • , Joseph T. McGuire
    • , Helena Melero
    • , Adriana S. Méndez Leal
    • , Benjamin Meyer
    • , Kristin N. Meyer
    • , Glad Mihai
    • , Georgios D. Mitsis
    • , Jorge Moll
    • , Dylan M. Nielson
    • , Gustav Nilsonne
    • , Michael P. Notter
    • , Emanuele Olivetti
    • , Adrian I. Onicas
    • , Paolo Papale
    • , Kaustubh R. Patil
    • , Jonathan E. Peelle
    • , Alexandre Pérez
    • , Doris Pischedda
    • , Jean-Baptiste Poline
    • , Yanina Prystauka
    • , Shruti Ray
    • , Patricia A. Reuter-Lorenz
    • , Richard C. Reynolds
    • , Emiliano Ricciardi
    • , Jenny R. Rieck
    • , Anais M. Rodriguez-Thompson
    • , Anthony Romyn
    • , Taylor Salo
    • , Gregory R. Samanez-Larkin
    • , Emilio Sanz-Morales
    • , Margaret L. Schlichting
    • , Douglas H. Schultz
    • , Qiang Shen
    • , Margaret A. Sheridan
    • , Jennifer A. Silvers
    • , Kenny Skagerlund
    • , Alec Smith
    • , David V. Smith
    • , Peter Sokol-Hessner
    • , Simon R. Steinkamp
    • , Sarah M. Tashjian
    • , Bertrand Thirion
    • , John N. Thorp
    • , Gustav Tinghög
    • , Loreen Tisdall
    • , Steven H. Tompson
    • , Claudio Toro-Serey
    • , Juan Jesus Torre Tresols
    • , Leonardo Tozzi
    • , Vuong Truong
    • , Luca Turella
    • , Anna E. van ‘t Veer
    • , Tom Verguts
    • , Jean M. Vettel
    • , Sagana Vijayarajah
    • , Khoi Vo
    • , Matthew B. Wall
    • , Wouter D. Weeda
    • , Susanne Weis
    • , David J. White
    • , David Wisniewski
    • , Alba Xifra-Porxas
    • , Emily A. Yearling
    • , Sangsuk Yoon
    • , Rui Yuan
    • , Kenneth S. L. Yuen
    • , Lei Zhang
    • , Xu Zhang
    • , Joshua E. Zosky
    • , Thomas E. Nichols
    • , Russell A. Poldrack
    •  & Tom Schonberg
  • Article |

    A specific type of glycosylation—sialylation—is more common on immunoglobulin E from individuals with a peanut allergys than from non-atopic people, suggesting that it has a role in regulating anaphylaxis.

    • Kai-Ting C. Shade
    • , Michelle E. Conroy
    • , Nathaniel Washburn
    • , Maya Kitaoka
    • , Daniel J. Huynh
    • , Emma Laprise
    • , Sarita U. Patil
    • , Wayne G. Shreffler
    •  & Robert M. Anthony
  • Article |

    Metal alloys consisting of three or more major elemental components show enhanced mechanical properties, which are now shown to be correlated with short-range order observed with electron microscopy.

    • Ruopeng Zhang
    • , Shiteng Zhao
    • , Jun Ding
    • , Yan Chong
    • , Tao Jia
    • , Colin Ophus
    • , Mark Asta
    • , Robert O. Ritchie
    •  & Andrew M. Minor
  • Article |

    • Dora Pinto
    • , Young-Jun Park
    • , Martina Beltramello
    • , Alexandra C. Walls
    • , M. Alejandra Tortorici
    • , Siro Bianchi
    • , Stefano Jaconi
    • , Katja Culap
    • , Fabrizia Zatta
    • , Anna De Marco
    • , Alessia Peter
    • , Barbara Guarino
    • , Roberto Spreafico
    • , Elisabetta Cameroni
    • , James Brett Case
    • , Rita E. Chen
    • , Colin Havenar-Daughton
    • , Gyorgy Snell
    • , Amalio Telenti
    • , Herbert W. Virgin
    • , Antonio Lanzavecchia
    • , Michael S. Diamond
    • , Katja Fink
    • , David Veesler
    •  & Davide Corti
  • Article |

    • Thomas H. C. Sit
    • , Christopher J. Brackman
    • , Sin Ming Ip
    • , Karina W. S. Tam
    • , Pierra Y. T. Law
    • , Esther M. W. To
    • , Veronica Y. T. Yu
    • , Leslie D. Sims
    • , Dominic N. C. Tsang
    • , Daniel K. W. Chu
    • , Ranawaka A. P. M. Perera
    • , Leo L. M. Poon
    •  & Malik Peiris
  • Article |

    Machine learning predicts Cu-Al electrocatalysts provide better efficiency and productivity than copper when using intermittent renewable electricity to convert carbon dioxide to useful chemicals and fuels.

    • Miao Zhong
    • , Kevin Tran
    • , Yimeng Min
    • , Chuanhao Wang
    • , Ziyun Wang
    • , Cao-Thang Dinh
    • , Phil De Luna
    • , Zongqian Yu
    • , Armin Sedighian Rasouli
    • , Peter Brodersen
    • , Song Sun
    • , Oleksandr Voznyy
    • , Chih-Shan Tan
    • , Mikhail Askerka
    • , Fanglin Che
    • , Min Liu
    • , Ali Seifitokaldani
    • , Yuanjie Pang
    • , Shen-Chuan Lo
    • , Alexander Ip
    • , Zachary Ulissi
    •  & Edward H. Sargent
  • Article |

    Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.

    • Neil F. Johnson
    • , Nicolas Velásquez
    • , Nicholas Johnson Restrepo
    • , Rhys Leahy
    • , Nicholas Gabriel
    • , Sara El Oud
    • , Minzhang Zheng
    • , Pedro Manrique
    • , Stefan Wuchty
    •  & Yonatan Lupu
  • Article |

    The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.

    • Lie Wang
    • , Hongwu Qian
    • , Yin Nian
    • , Yimo Han
    • , Zhenning Ren
    • , Hanzhi Zhang
    • , Liya Hu
    • , B. V. Venkataram Prasad
    • , Arthur Laganowsky
    • , Nieng Yan
    •  & Ming Zhou
  • Article |

    The pulsation spectra of intermediate-mass stars (so-called δ Scuti stars) have been challenging to analyse, but new observations of 60 such stars reveal remarkably regular sequences of high-frequency pulsation modes.

    • Timothy R. Bedding
    • , Simon J. Murphy
    • , Daniel R. Hey
    • , Daniel Huber
    • , Tanda Li
    • , Barry Smalley
    • , Dennis Stello
    • , Timothy R. White
    • , Warrick H. Ball
    • , William J. Chaplin
    • , Isabel L. Colman
    • , Jim Fuller
    • , Eric Gaidos
    • , Daniel R. Harbeck
    • , J. J. Hermes
    • , Daniel L. Holdsworth
    • , Gang Li
    • , Yaguang Li
    • , Andrew W. Mann
    • , Daniel R. Reese
    • , Sanjay Sekaran
    • , Jie Yu
    • , Victoria Antoci
    • , Christoph Bergmann
    • , Timothy M. Brown
    • , Andrew W. Howard
    • , Michael J. Ireland
    • , Howard Isaacson
    • , Jon M. Jenkins
    • , Hans Kjeldsen
    • , Curtis McCully
    • , Markus Rabus
    • , Adam D. Rains
    • , George R. Ricker
    • , Christopher G. Tinney
    •  & Roland K. Vanderspek
  • Article |

    Cryo-electron microscopy structures and functional and mutagenesis studies provide insights into the catalysis of triacylglycerol synthesis by human acyl-CoA diacylglycerol acyltransferase at its intramembrane active site.

    • Xuewu Sui
    • , Kun Wang
    • , Nina L. Gluchowski
    • , Shane D. Elliott
    • , Maofu Liao
    • , Tobias C. Walther
    •  & Robert V. Farese Jr
  • Article |

    The structure of human ACAT1, which catalyses the transfer of an acyl group from acyl-coenzyme A to cholesterol to form cholesteryl ester, is resolved by cryo-electron microscopy.

    • Hongwu Qian
    • , Xin Zhao
    • , Renhong Yan
    • , Xia Yao
    • , Shuai Gao
    • , Xue Sun
    • , Ximing Du
    • , Hongyuan Yang
    • , Catherine C. L. Wong
    •  & Nieng Yan
  • Article |

    Shared synteny guides loss-of-function analysis of human enhancer homologues in mice, identifying a distal enhancer at the autoimmune and allergic disease risk locus at chromosome 11q13.5 whose function in regulatory T cells provides a mechanistic basis for its role in disease.

    • Rabab Nasrallah
    • , Charlotte J. Imianowski
    • , Lara Bossini-Castillo
    • , Francis M. Grant
    • , Mikail Dogan
    • , Lindsey Placek
    • , Lina Kozhaya
    • , Paula Kuo
    • , Firas Sadiyah
    • , Sarah K. Whiteside
    • , Maxwell R. Mumbach
    • , Dafni Glinos
    • , Panagiota Vardaka
    • , Carly E. Whyte
    • , Teresa Lozano
    • , Toshitsugu Fujita
    • , Hodaka Fujii
    • , Adrian Liston
    • , Simon Andrews
    • , Adeline Cozzani
    • , Jie Yang
    • , Suman Mitra
    • , Enrico Lugli
    • , Howard Y. Chang
    • , Derya Unutmaz
    • , Gosia Trynka
    •  & Rahul Roychoudhuri
  • Article |

    Within three-dimensional environments, leukocytes can migrate even in the complete absence of adhesive forces using the topographical features of the substrate to propel themselves.

    • Anne Reversat
    • , Florian Gaertner
    • , Jack Merrin
    • , Julian Stopp
    • , Saren Tasciyan
    • , Juan Aguilera
    • , Ingrid de Vries
    • , Robert Hauschild
    • , Miroslav Hons
    • , Matthieu Piel
    • , Andrew Callan-Jones
    • , Raphael Voituriez
    •  & Michael Sixt
  • Article |

    A squeezed collective state of 1011 rubidium atoms is generated by quantum non-demolition measurements, and the accuracy of the estimation of their collective spin is improved using past quantum state retrodiction.

    • Han Bao
    • , Junlei Duan
    • , Shenchao Jin
    • , Xingda Lu
    • , Pengxiong Li
    • , Weizhi Qu
    • , Mingfeng Wang
    • , Irina Novikova
    • , Eugeniy E. Mikhailov
    • , Kai-Feng Zhao
    • , Klaus Mølmer
    • , Heng Shen
    •  & Yanhong Xiao
  • Article |

    A massively parallel coherent light detection and ranging (lidar) scheme using a soliton microcomb—a light source that emits a wide spectrum of sharp lines with equally spaced frequencies—is described.

    • Johann Riemensberger
    • , Anton Lukashchuk
    • , Maxim Karpov
    • , Wenle Weng
    • , Erwan Lucas
    • , Junqiu Liu
    •  & Tobias J. Kippenberg
  • Article |

    The intercalation of native atoms into bilayer transition metal dichalcogenides during growth generates ultrathin, covalently bonded materials into which ferromagnetic ordering can be introduced.

    • Xiaoxu Zhao
    • , Peng Song
    • , Chengcai Wang
    • , Anders C. Riis-Jensen
    • , Wei Fu
    • , Ya Deng
    • , Dongyang Wan
    • , Lixing Kang
    • , Shoucong Ning
    • , Jiadong Dan
    • , T. Venkatesan
    • , Zheng Liu
    • , Wu Zhou
    • , Kristian S. Thygesen
    • , Xin Luo
    • , Stephen J. Pennycook
    •  & Kian Ping Loh