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A high-resolution cryo-electron microscopy structure is reported for the full-length human α1β3γ2L GABAA receptor, functionally reconstituted in lipid nanodiscs.
In a mouse model of ischaemic stroke, regulatory T cells infiltrate the injured brain in response to the chemokines CCL1 and CCL20 and suppress excessive astrogliosis via the production of amphiregulin.
ENCODE mapped long-range looping interactions between functional elements and genes, placing them in a three-dimensional context to reveal their functional relationships
ENCODE provides an initial interpretation of many human variants and plausible leads for the role of many variants identified in genome-wide association studies