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The crystal structure of the full-length glucagon receptor in complex with a glucagon analogue NNC1702 reveals how the peptide ligand interacts with its target and shows the conformational changes required for receptor activation.
An approach is developed for the continuous fabrication of lateral multi-junction heterostructures of transition-metal dichalcogenides, in which the sequential formation of heterojunctions is achieved solely by changing the composition of the reactive gas environment in the presence of water vapour.
Whole-genome sequencing and comparative genomic analysis of immune-related genes of Cercocebus atys and Macaca mulatta identify candidate genes, such as ICAM2 and TLR4, that may explain the AIDS resistance of C. atys.
Noble gases trapped in ice cores are used to show that the mean global ocean temperature increased by 2.6 degrees Celsius over the last glacial transition and is closely correlated with Antarctic temperature.
A 2D topological charge pump in a photonic waveguide array is used to observe boundary physics associated with the 4D quantum Hall effect experimentally.
Heterologous expression of engineered gas vesicles allows noninvasive, deep-tissue ultrasound visualization of engineered bacteria in vivo in mouse tumour models and in the gastrointestinal tract.
The crystal structure of the complement receptor C5aR1 bound to a small-molecule antagonist provides insights into this receptor class and how they could be better targeted therapeutically.
By implementing a 2D topological charge pump using ultracold bosonic atoms, the theoretically predicted 4D integer quantum Hall effect is confirmed experimentally.