Outlook

The search is on for disease-modifying treatments for Parkinson's disease, but, as Ruth Williams discovers, developing a compound is only part of the problem.

Alison Abbott explores the history of the first treatment for Parkinson's disease since its dramatic debut in the swinging sixties.

To have any hope of affecting the course of Parkinson's disease, early diagnosis is essential. Rachel Jones assesses progress so far.

Parkinson's disease might have much in common with Alzheimer's disease, prion diseases and other protein-aggregation disorders. Jim Schnabel investigates.

Cell replacement, gene therapy, and electrical and optical stimulation for the brain — Kerri Smith looks to the future of Parkinson's disease therapies.

The lack of a good animal model is frustrating efforts to curb disease progression, explains M. Flint Beal.

HIV keeps the immune system in a hyperactive state, gradually leading to its ruin, reports Emma Marris.

Studies comparing HIV infection and its simian counterpart in different monkey species are filling gaps in knowledge, explains Bijal Trivedi.

Recent successes are reinvigorating research into a vaccine for HIV, reports Cassandra Willyard.

There is more to combating HIV in the developing world than providing affordable drugs. T. V. Padma looks at the innovative new strategies being employed.

A Cambodian group has developed a pioneering community-based approach to HIV and TB care and research. Amy Maxmen describes how this powerful model is being expanded to other war-torn countries.

Researchers hope to unlock the secrets of the select few who rein in, or even resist, HIV infection, says Bijal Trivedi.

Sarah DeWeerdt describes the intricate relationship between HIV and the host immune system, each influencing the other's next moves.

For many people in the developed world HIV is no longer the death sentence it once was. Paroma Basu explores the consequences of complacency.

No single strategy alone is likely to thwart HIV's spread. Researchers are turning to 'prevention packages' of two or more approaches, Cassandra Willyard reports.

Co-infection with HIV and tuberculosis is a potent combination. Amy Maxmen investigates the impact of this deadly duo.

Specialization has its place, but truly innovative advances in HIV research usually come from interdisciplinary efforts, reports Unmesh Kher.

There is a formidable arsenal of drugs available to treat HIV. Virginia Hughes finds that, for the first time in years, there is also renewed hope of a cure.