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CDC7 inhibition selectively induces senescence in hepatocellular carcinoma cells with TP53 mutations, which enables the selective apoptotic cell death of these senescent cells using inhibitors of mTOR signalling.
Estimates for when critical environmental streamflow limits will be reached—with potentially devastating economic and environmental effects—are obtained using a global model that links groundwater pumping with the groundwater flow to rivers.
Tadpoles of strawberry poison frogs (Oophaga pumilio) are shown to imprint on adult coloration, affecting both male aggression biases and female preferences and setting the stage for speciation by sexual selection.
Sea level varied by 13 ± 5 metres on average, but up to 25 metres, over glacial–interglacial cycles during the Pliocene epoch, due to partial collapses of Antarctic Ice Sheets.
There are two distinct kinematic populations of globular clusters in Messier 31 (M31, the Andromeda galaxy) with rotation axes perpendicular to each other, suggesting that they arose from merger events separated by billions of years.
The Berry phase of graphene is measured in the absence of an applied magnetic field by observing dislocations in the Friedel oscillations formed at a hydrogen atom adsorbed on graphene.
Clinical benefit was observed in 34% of a cohort of 215 patients with cancer who received treatment with anticancer drugs outside of their approved label, in the Drug Rediscovery protocol trial.
An analysis of the B cell receptor repertoire in six immune-mediated diseases reveals that there are substantial differences in clonality, isotype use, class switching and use of the IGHV genes between diseases.
PdMo bimetallene, a highly curved and sub-nanometre-thick nanosheet of a palladium–molybdenum alloy, is an efficient and stable electrocatalyst for the oxygen reduction and evolution reactions under alkaline conditions.
After the Cretaceous/Palaeogene mass extinction event, nannoplankton communities exhibited volatility for 1.8 million years before a more stable community emerged, coinciding with restoration of the carbon cycle and a fully functioning biological pump between the surface and deep sea.
Juxtaposition of region-specific gut spheroids derived from human pluripotent stem cells in the absence of extrinsic factors results in development of segregated hepato-biliary-pancreatic anlages that recapitulate early morphogenetic events.
Globally distributed kimberlites have their origins in a single, homogeneous early Earth reservoir that was subsequently perturbed, probably by subduction along the margins of Pangaea, around 200 million years ago.
X-ray diffraction measurements of solid hydrogen provide crystallographic information for high-pressure phases of hydrogen and transitions between them, suggesting a series of isostructural transitions under compression before band closure and metallization.
A crystal structure of Thermoplasmatales archaeon heliorhodopsin at 2.4 Å resolution shows that it adopts a similar fold to that of type I rhodopsin—despite the low sequence identity—but there are also several marked differences that provide insights into heliorhodopsin function.
FHL1 is a key factor expressed by humans and mice that is required for chikungunya virus infection and is therefore a promising target for the development of therapies against chikungunya virus.
Transmission of single-spin and entangled quantum states without the physical displacement of electrons is demonstrated in a quadruple quantum dot array using the Heisenberg exchange interaction and coherent SWAP gates.
Nutrient content analyses of marine finfish and current fisheries landings show that fish have the potential to substantially contribute to global food and nutrition security by alleviating micronutrient deficiencies in regions where they are prevalent.
17O nuclear magnetic resonance measurements on Sr2RuO4 reveal a drop of the Knight shift in the superconducting state, contradicting previous work and imposing tight constraints on the order parameter symmetry of the system.