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Five scientists nominated by their peers have created nurturing research environments and fostered fields and careers far beyond their labs. Carina Dennis and Janet Wright give credit where it's long overdue.
Coordination and integration of the results of animal research are an ever-increasing challenge. Jane Qiu finds out what happens when big biology meets a small rodent.
Crystal structures show that botulinum toxins bind simultaneously to two sites on neurons. This dual interaction allows them to use a Trojan-horse strategy to enter nerve terminals, with deadly effect.
A spin-off from a UK university has established a solid niche as a leading supplier of microsatellites. But taking the company to the next level is a challenge. Geoff Brumfiel reports.
This paper, one of two published that show Sld2 and Sld3 constitute the minimal group of cyclin-dependent kinase (CDK) targets necessary to promote replication, also finds that the function of G1 CDKs in replication is not just to activate the S-phase CDKs, but also to regulate the Cdc7 kinase regulatory subunit, Dbf4.
This paper, one of two published that show Sld2 and Sld3 constitute the minimal group of cyclin-dependent kinase (CDK) targets necessary to promote replication, also finds that the function of G1 CDKs in replication is not just to activate the S-phase CDKs, but also to regulate the Cdc7 kinase regulatory subunit, Dbf4.
Protein microarrays are coming of age, and the development of specialized technologies is extending their high-throughput capabilities. Michael Eisenstein reports.
One of two papers that describe how botulinum toxins produced by Clostridium botulinum are potent inhibitors of neurotransmitter release by elucidating the crystal structure of botulinum toxin B bound to its receptor.
One of two papers that describe how botulinum toxins produced by Clostridium botulinum are potent inhibitors of neurotransmitter release by elucidating the crystal structure of botulinum toxin B bound to its receptor.
Identification of two CO2 receptors in Drosophila antennae, Gr21a and Gr63a, determines that their co-expression is necessary and sufficient for CO2 sensing. Flies lacking one of the two are insensitive to CO2, and confer CO2 responsivity when both receptors are expressed in heterologous neurons.