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Why did Mars lose so much of its surface water, whereas Earth retained its? Models of the evolution of minerals on the two planets suggest one explanation: the Martian water was drawn into the planetary interior.
Some chemotherapies block cancer growth by driving tumour cells into a state of cell-division arrest termed senescence. It emerges that such cells have a boosted capacity to drive tumour growth if they exit senescence.
The observed electromagnetic emission from GW170817 suggests that a ‘cocoon’ of mildly relativistic material was released as a jet transferred its energy to the neutron-rich dynamical ejecta from the merger.
Cellular senescence induced by chemotherapy leads to the acquisition of stemness in cancer cells, which results in enhanced tumour-promoting capacity after forced release or spontaneous escape from the senescent cell-cycle arrest.
Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.
Analyses of potential and actual biomass stocks indicate that trade-offs exist between conserving carbon stocks on managed land and raising the contribution of biomass to raw material and energy supply for the mitigation of climate change.
CRISPR–Cas9 genome editing is used to correct a dominant-negative mutation in a mouse model of inherited deafness, resulting in improvements in cochlear function and hearing.
The cryo-electron microscopy structure of full-length mouse Piezo1 reveals six Piezo repeats, and 26 transmembrane helices per protomer, and shows that a kinked helical beam and anchor domain link the Piezo repeats to the pore and control gating allosterically.
Statistical modelling of global survey datasets of waterbirds as an indicator taxon for biodiversity changes in wetland ecosystems demonstrates that effective governance is the strongest predictor of species abundance increases and conservation benefits.
The cryo-electron microscopy structure of the calcium channel TRPV6 in its open and closed states demonstrates a novel gating mechanism involving an alanine hinge.